INT64719

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.84
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1B, IL6) aging (IL1B, IL6) extracellular region (IL1B, IL6)
cytosol (IL1B) signal transduction (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
tendon cells 1
decidua 1
IL1B (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 56 100.00 Very High Very High Very High
COX2 14 100.00 Very High Very High Very High
cINOD 8 99.92 Very High Very High Very High
cOX1 2 99.20 Very High Very High Very High
Dismenorea 1 98.16 Very High Very High Very High
Inflammation 83 97.76 Very High Very High Very High
Lasting pain 2 96.60 Very High Very High Very High
Inflammatory response 9 90.00 High High
Inflammatory mediators 2 88.64 High High
metalloproteinase 14 88.36 High High
Disease Link Frequency Relevance Heat
Cancer 9 100.00 Very High Very High Very High
Infection 10 99.96 Very High Very High Very High
Necrosis 6 99.92 Very High Very High Very High
Cumulative Trauma Disorders 2 99.04 Very High Very High Very High
Anaplastic Astrocytoma 2 98.52 Very High Very High Very High
Injury 4 98.20 Very High Very High Very High
Dysmenorrhea 1 98.16 Very High Very High Very High
INFLAMMATION 99 97.76 Very High Very High Very High
Pain 3 96.60 Very High Very High Very High
Disease 21 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of NSAIDs on IL-1 beta-induced IL-6 mRNA and protein synthesis in human astrocytoma cells.
IL-1 Positive_regulation (induced) of IL-6 associated with anaplastic astrocytoma and cinod
1) Confidence 0.41 Published 1996 Journal Neuroreport Section Title Doc Link 8817534 Disease Relevance 0.65 Pain Relevance 0.50
IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells.
IL-1 Positive_regulation (induces) of IL-6 in tendon cells associated with cox2
2) Confidence 0.26 Published 2003 Journal J. Orthop. Res. Section Title Doc Link 12568957 Disease Relevance 0.63 Pain Relevance 0.62
IL-1 beta (1 nM) induced mRNAs for cyclooxygenase 2 (COX2), MMP-1, -3, -13 and aggrecanase-1 as well as IL-1 beta and IL-6, whereas mRNAs for COX1 and MMP-2 were expressed constitutively.
IL-1 Positive_regulation (induced) of IL-6 associated with cox2 and cox1
3) Confidence 0.26 Published 2003 Journal J. Orthop. Res. Section Abstract Doc Link 12568957 Disease Relevance 0.57 Pain Relevance 0.68
We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13, IL-1beta and tumor necrosis factor-alpha.
IL-1beta Positive_regulation (response) of IL-6 associated with necrosis and cancer
4) Confidence 0.20 Published 2006 Journal J. Urol. Section Abstract Doc Link 16407046 Disease Relevance 0.60 Pain Relevance 0.08
stimulates expression of IL-1 and IL-6, and IL-1 can induce both IL-6 and TNF-?
IL-1 Positive_regulation (induce) of IL-6
5) Confidence 0.11 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2946274 Disease Relevance 1.41 Pain Relevance 0.35
stimulates expression of IL-1 and IL-6, and IL-1 can induce both IL-6 and TNF-?
IL-1 Positive_regulation (induce) of IL-6
6) Confidence 0.05 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2946274 Disease Relevance 1.42 Pain Relevance 0.35
The production of PGE2, MMP-1, IL-8, IL-6, RANTES and IP-10 induced by hTWEAK (but not the production induced by TNF and IL-1?)
IL-1 Positive_regulation (induced) of IL-6
7) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.38 Pain Relevance 0.04
In the setting of infection, IL-1 and TNF have a synergistic effect on the acute phase cytokine IL-6 with increased production in trophoblasts and chorion and to a lesser extent decidua [5].
IL-1 Positive_regulation (effect) of IL-6 in decidua associated with infection and cytokine
8) Confidence 0.01 Published 2005 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC554771 Disease Relevance 1.19 Pain Relevance 0.52

General Comments

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