INT64723

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Context Info
Confidence 0.61
First Reported 1996
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 12.59
Pain Relevance 5.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
plasma 4
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 9 100.00 Very High Very High Very High
antidepressant 49 99.96 Very High Very High Very High
cytokine 437 99.84 Very High Very High Very High
reflex sympathetic dystrophy 21 99.42 Very High Very High Very High
Paracetamol 3 98.98 Very High Very High Very High
Inflammatory response 27 97.96 Very High Very High Very High
Inflammation 300 97.76 Very High Very High Very High
Chronic pancreatitis 33 91.84 High High
pulpitis 2 90.12 High High
Mcgill questionnaire 1 85.20 High High
Disease Link Frequency Relevance Heat
Keloid Scars 104 100.00 Very High Very High Very High
Complex Regional Pain Syndromes 27 99.42 Very High Very High Very High
Radiation Pneumonitis 56 99.24 Very High Very High Very High
Overdose 2 99.16 Very High Very High Very High
Cardiovascular Disease 11 99.08 Very High Very High Very High
Anaplastic Astrocytoma 3 98.52 Very High Very High Very High
Atherosclerosis 4 98.00 Very High Very High Very High
INFLAMMATION 365 97.76 Very High Very High Very High
Primary Sclerosing Cholangitis 77 97.28 Very High Very High Very High
Cancer 124 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reverse transcriptase-polymerase chain reaction experiments showed that the increase was dependent on the enhancement of IL-6 mRNA levels.
Regulation (dependent) of Positive_regulation (increase) of IL-6
1) Confidence 0.61 Published 1998 Journal J Endod Section Abstract Doc Link 9641129 Disease Relevance 0.17 Pain Relevance 0.26
Although the average increase in plasma IL-6 was not significant, there were marked individual differences in this response, with changes in IL-6 ranging from ?
Neg (not) Regulation (significant) of Positive_regulation (increase) of IL-6 in plasma
2) Confidence 0.45 Published 2010 Journal Journal of Psychosomatic Research Section Body Doc Link PMC2809922 Disease Relevance 0.90 Pain Relevance 0
The analysis of the plasma concentrations of IL-6 and TNF-?
Regulation (analysis) of Positive_regulation (concentrations) of IL-6 in plasma
3) Confidence 0.44 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 0.10 Pain Relevance 0
Chronic levels of both CRP and IL-6 have been identified as important
Regulation (important) of Positive_regulation (levels) of IL-6
4) Confidence 0.38 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513328 Disease Relevance 1.77 Pain Relevance 0.26
This study investigated the effect of five days of oral indomethacin treatment (75 mg per day) on the serum concentrations of IL-6, IL-10, IL-12, and TNF-alpha induced by exercising healthy volunteers.
Spec (investigated) Regulation (effect) of Positive_regulation (induced) of IL-6
5) Confidence 0.37 Published 2002 Journal Cytokine Section Abstract Doc Link 12242082 Disease Relevance 0.36 Pain Relevance 0.45
Numerous studies emphasize the important role of IL-6 and TGF-?
Regulation (emphasize) of Positive_regulation (role) of IL-6
6) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483418 Disease Relevance 1.69 Pain Relevance 0.13
However, whether the increasing level of IL-6 is directly responsible antidepressants themselves is still an undefined issue.
Spec (whether) Regulation (responsible) of Positive_regulation (increasing) of IL-6 associated with antidepressant
7) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2872762 Disease Relevance 0.56 Pain Relevance 0.60
These results confirm the findings of Munnikes et al. who studied patients with an intermediate duration of CRPS (median 20 months) and also found a significant elevation of IL-6 and TNF-?
Regulation (found) of Positive_regulation (elevation) of IL-6 associated with reflex sympathetic dystrophy
8) Confidence 0.29 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 0.99 Pain Relevance 0.60
A robust elevation of IL-6 and IL-17 expression in keloid is confirmed by cytokine array, western blot and ELISA analyses.
Spec (analyses) Regulation (confirmed) of Positive_regulation (elevation) of IL-6 associated with keloid scars and cytokine
9) Confidence 0.27 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2771422 Disease Relevance 1.22 Pain Relevance 0.21
Effects of NSAIDs on IL-1 beta-induced IL-6 mRNA and protein synthesis in human astrocytoma cells.
Regulation (Effects) of Positive_regulation (induced) of IL-6 associated with anaplastic astrocytoma and cinod
10) Confidence 0.27 Published 1996 Journal Neuroreport Section Title Doc Link 8817534 Disease Relevance 0.65 Pain Relevance 0.50
In one recent study of 72 women, depressed women had higher levels of IL-6 and TNF-?
Regulation (had) of Positive_regulation (levels) of IL-6
11) Confidence 0.27 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1855049 Disease Relevance 1.74 Pain Relevance 0.79
A study of acetaminophen overdose in a clinical population demonstrated an increase in IL8, IL6, and MCP-1 in the most severely affected patients (based on serum ALT), yet only MCP-1 had a good correlation (R2 = 0.607) over the range of severity (James et al., 2005).
Regulation (affected) of Positive_regulation (increase) of IL6 associated with paracetamol and overdose
12) Confidence 0.24 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.41 Pain Relevance 0.49
Exposure to LPS stimulated increased IL-6 release from the amniotic and choriodecidual sides of the membranes (Fig. 2B; ANOVA LPS treatment effect, p = 0.008), but the pattern of IL-6 response was different for the amniotic versus the choriodecidual side of the membranes depending on the treatment modality (ANOVA treatment * membrane side interaction, p = 0.03).
Regulation (different) of Positive_regulation (response) of IL-6
13) Confidence 0.22 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0 Pain Relevance 0
Electrophoretic mobility shift and reporter gene assays revealed that tepoxalin exerts its inhibitory effect through the inhibition of nuclear factor kappaB (NF-kappaB), a transcription factor involved in the induction of IL-1, IL-6 and ACT gene expression.
Regulation (involved) of Positive_regulation (induction) of IL-6
14) Confidence 0.21 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10471086 Disease Relevance 0.43 Pain Relevance 0.40
There is also an inverse regulation of IL-6 and MCP-1 mRNA induction by PBMC derived from different sources: while the increase in IL-6 expression on the mRNA level was only seen in PBMC from healthy donors, MCP-1 was significantly induced in cocultured PBMC from donors, CP and septic shock patients.
Regulation (regulation) of Positive_regulation (induction) of IL-6 associated with chronic pancreatitis and sepsis
15) Confidence 0.14 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.60 Pain Relevance 0.49
Systemic concentrations of tumour necrosis factor alpha (TNF), interleukin-1 beta (IL-1), interleukin-6 (IL-6), cortisol, epinephrine and norepinephrine were measured before and during the operation and subsequently for up to 48 h postoperatively.
Regulation (measured) of Positive_regulation (concentrations) of IL-6
16) Confidence 0.05 Published 1999 Journal Acta Anaesthesiol Scand Section Body Doc Link 10027020 Disease Relevance 0 Pain Relevance 0

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