INT64724

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 13.63
Pain Relevance 5.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
plasma 10
muscle 4
synovial fluid 2
smooth muscle 2
cartilage 2
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 221 100.00 Very High Very High Very High
Osteoarthritis 237 99.84 Very High Very High Very High
cINOD 17 99.72 Very High Very High Very High
Inflammation 350 99.36 Very High Very High Very High
antagonist 11 97.48 Very High Very High Very High
Angina 21 97.44 Very High Very High Very High
pulpitis 6 89.92 High High
diclofenac 3 84.96 Quite High
Pain 57 77.64 Quite High
rheumatoid arthritis 8 66.36 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 240 99.84 Very High Very High Very High
Anaplastic Astrocytoma 6 99.60 Very High Very High Very High
INFLAMMATION 437 99.36 Very High Very High Very High
Myocardial Infarction 73 99.12 Very High Very High Very High
Adhesions 51 98.84 Very High Very High Very High
Endometriosis (extended) 22 98.74 Very High Very High Very High
Hyperplasia 5 97.52 Very High Very High Very High
Stable Angina Pectoris 4 97.44 Very High Very High Very High
Muscular Atrophy 7 97.08 Very High Very High Very High
Disease 181 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The three promoter variations G-597A, G-572C and G-174C have been shown to influence IL-6 transcription through a complex interaction determined by the haplotype, and the G alleles at these loci have been found to associate with increased transcription of IL-6 [16].
Positive_regulation (increased) of Transcription (transcription) of IL-6
1) Confidence 0.69 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 0.99 Pain Relevance 0.58
A significant increase in the level of IL-6 mRNA has been detected in OA-affected cartilage, and the IL-6 levels in the serum and synovial fluid have been reported to be elevated among OA patients [12].
Positive_regulation (increase) of Transcription (level) of IL-6 in synovial fluid associated with osteoarthritis
2) Confidence 0.69 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 1.32 Pain Relevance 0.62
Simultaneous addition of IL-1alpha and PGE2 or TNF-alpha and PGE2 to the cultures significantly reduced the cytokine-induced IL-6 mRNA synthesis ranging from 45% to 65%.
Positive_regulation (induced) of Transcription (synthesis) of IL-6 in PGE2 associated with cytokine
3) Confidence 0.62 Published 2002 Journal J Endod Section Abstract Doc Link 12017180 Disease Relevance 0.41 Pain Relevance 0.30
Additional clues came from the observations that menopause or ovariectomy resulted in increased IL-6 serum levels [153], increased IL-6 mRNA levels in bone cells [154], and increased IL-6 secretion by mononuclear cells [155-157].
Positive_regulation (increased) of Transcription (levels) of IL-6 in mononuclear cells associated with endometriosis (extended)
4) Confidence 0.60 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 1.37 Pain Relevance 0.07
Serum IL-6 was strongly correlated to the increase in muscle IL-6 mRNA (r2?
Positive_regulation (increase) of Transcription (mRNA) of IL-6 in muscle
5) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.06 Pain Relevance 0
In the present study a positive correlation between circulating IL-6 and muscle IL-6 mRNA expression was observed (Fig. 1c), suggesting that muscle-derived IL-6 protein may be released into circulation accounting for the rise in plasma IL-6.
Positive_regulation (muscle) of Transcription (expression) of IL-6 in plasma
6) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.06 Pain Relevance 0
In the present study a positive correlation between circulating IL-6 and muscle IL-6 mRNA expression was observed (Fig. 1c), suggesting that muscle-derived IL-6 protein may be released into circulation accounting for the rise in plasma IL-6.
Positive_regulation (muscle) of Transcription (expression) of IL-6 in plasma
7) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.06 Pain Relevance 0
Serum IL-6 was strongly correlated to the increase in muscle IL-6 mRNA (r2?
Positive_regulation (muscle) of Transcription (mRNA) of IL-6 in muscle
8) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.06 Pain Relevance 0
In the present study a positive correlation between circulating IL-6 and muscle IL-6 mRNA expression was observed (Fig. 1c), suggesting that muscle-derived IL-6 protein may be released into circulation accounting for the rise in plasma IL-6.
Positive_regulation (circulating) of Transcription (expression) of IL-6 in plasma
9) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.07 Pain Relevance 0
In the present study a positive correlation between circulating IL-6 and muscle IL-6 mRNA expression was observed (Fig. 1c), suggesting that muscle-derived IL-6 protein may be released into circulation accounting for the rise in plasma IL-6.
Positive_regulation (circulating) of Transcription (expression) of IL-6 in plasma
10) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.07 Pain Relevance 0
In the present study, the effects of seven non-steroidal anti-inflammatory drugs (NSAIDs) on interleukin-1 beta (IL-1 beta)-induced IL-6 mRNA expression and protein synthesis in a human astrocytoma cell line were investigated.
Spec (investigated) Positive_regulation (-) of Transcription (expression) of IL-6 associated with anaplastic astrocytoma, inflammation and cinod
11) Confidence 0.46 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817534 Disease Relevance 0.63 Pain Relevance 0.50
In the present study, the effects of seven non-steroidal anti-inflammatory drugs (NSAIDs) on interleukin-1 beta (IL-1 beta)-induced IL-6 mRNA expression and protein synthesis in a human astrocytoma cell line were investigated.
Positive_regulation (induced) of Transcription (expression) of IL-6 associated with anaplastic astrocytoma, inflammation and cinod
12) Confidence 0.46 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817534 Disease Relevance 0.63 Pain Relevance 0.50
Effects of NSAIDs on IL-1 beta-induced IL-6 mRNA and protein synthesis in human astrocytoma cells.
Positive_regulation (induced) of Transcription (synthesis) of IL-6 associated with anaplastic astrocytoma and cinod
13) Confidence 0.46 Published 1996 Journal Neuroreport Section Title Doc Link 8817534 Disease Relevance 0.65 Pain Relevance 0.51
Reverse transcriptase-polymerase chain reaction experiments showed that the increase was dependent on the enhancement of IL-6 mRNA levels.
Positive_regulation (enhancement) of Transcription (levels) of IL-6
14) Confidence 0.46 Published 1998 Journal J Endod Section Abstract Doc Link 9641129 Disease Relevance 0.17 Pain Relevance 0.26
It has been previously demonstrated that exercise can induce increases in muscle derived IL-6 mRNA and plasma IL-6 concentrations following exercise [25], [26].
Positive_regulation (increases) of Transcription (derived) of IL-6 in plasma
15) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.64 Pain Relevance 0.11
The expression of IL-6 mRNA induced by Ang II was completely blocked by an Ang II type 1 receptor antagonist, CV11974.
Positive_regulation (induced) of Transcription (expression) of IL-6 associated with antagonist
16) Confidence 0.43 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.50 Pain Relevance 0.08
Ang II significantly increases the expression of IL-6 mRNA and protein in vascular smooth muscle, in a dose-dependent manner.
Positive_regulation (increases) of Transcription (expression) of IL-6 in smooth muscle
17) Confidence 0.43 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.51 Pain Relevance 0
Ang II significantly increased the expression of IL-6 mRNA and protein in a dose-dependent manner (10(-10) to 10(-6) mol/L).
Positive_regulation (increased) of Transcription (expression) of IL-6
18) Confidence 0.43 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.49 Pain Relevance 0.07
In one study Ang II treatment induced IL-6 transcription by inducing cytoplasmic-to-nuclear translocation of the NF-kappaB subunits Rel A and NF-kappaB1 with parallel changes in DNA-binding activity in a biphasic manner, which produced an early peak at 15 minutes followed by a nadir 1 to 6 hours later and a later peak at 24 hours [60].


Positive_regulation (induced) of Transcription (transcription) of IL-6
19) Confidence 0.43 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.20 Pain Relevance 0.10
Tenidap induced a somewhat similar reduction pattern of IL-1 beta and IL-6 mRNA to that observed for cytokine synthesis.
Positive_regulation (induced) of Transcription (pattern) of IL-6
20) Confidence 0.42 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8838503 Disease Relevance 0 Pain Relevance 0

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