INT64725

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Context Info
Confidence 0.45
First Reported 1996
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 7.96
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
plasma 2
hepatocyte 2
fat cell 2
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 36 100.00 Very High Very High Very High
cINOD 12 100.00 Very High Very High Very High
Inflammation 110 98.84 Very High Very High Very High
Osteoarthritis 264 93.68 High High
diclofenac 3 92.64 High High
Inflammatory response 8 91.52 High High
rheumatoid arthritis 84 90.56 High High
Inflammatory marker 10 84.68 Quite High
Pain 58 71.20 Quite High
Inflammatory mediators 4 50.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 142 100.00 Very High Very High Very High
Anaplastic Astrocytoma 6 99.60 Very High Very High Very High
Cancer 22 98.88 Very High Very High Very High
Endometriosis (extended) 3 98.84 Very High Very High Very High
Appetite Loss 7 98.56 Very High Very High Very High
Disease 59 98.52 Very High Very High Very High
Obesity 152 98.04 Very High Very High Very High
Death 12 97.68 Very High Very High Very High
Necrosis 7 97.52 Very High Very High Very High
Rheumatic Diseases 10 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The three promoter variations G-597A, G-572C and G-174C have been shown to influence IL-6 transcription through a complex interaction determined by the haplotype, and the G alleles at these loci have been found to associate with increased transcription of IL-6 [16].
Regulation (influence) of Transcription (transcription) of IL-6
1) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 0.95 Pain Relevance 0.54
This variation regulates the transcription of the IL-6 gene and is associated with plasma levels of IL-6 [15].
Regulation (regulates) of Transcription (transcription) of IL-6 in plasma
2) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 0.63 Pain Relevance 0.30
There is substantial evidence that the increase in IL-6 serum levels with age results in part from the loss of sex steroids such as estrogen, testosterone and dehydroepiandrosterone [36,37], which have an important role in blocking transcription of the IL-6 gene, so that their loss at menopause may have a more conspicuous role than the genotype.
Regulation (role) of Transcription (transcription) of IL-6 associated with endometriosis (extended)
3) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 0.81 Pain Relevance 0.34
While the effects of naproxen and meloxicam were small and restricted to protein synthesis, tenidap strongly inhibited IL-6 protein synthesis and also affected IL-6 mRNA levels.
Regulation (affected) of Transcription (levels) of IL-6
4) Confidence 0.27 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817534 Disease Relevance 0.54 Pain Relevance 0.50
Effects of NSAIDs on IL-1 beta-induced IL-6 mRNA and protein synthesis in human astrocytoma cells.
Regulation (Effects) of Transcription (synthesis) of IL-6 associated with anaplastic astrocytoma and cinod
5) Confidence 0.27 Published 1996 Journal Neuroreport Section Title Doc Link 8817534 Disease Relevance 0.65 Pain Relevance 0.51
In the present study, the effects of seven non-steroidal anti-inflammatory drugs (NSAIDs) on interleukin-1 beta (IL-1 beta)-induced IL-6 mRNA expression and protein synthesis in a human astrocytoma cell line were investigated.
Spec (investigated) Regulation (effects) of Transcription (expression) of IL-6 associated with anaplastic astrocytoma, inflammation and cinod
6) Confidence 0.27 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817534 Disease Relevance 0.65 Pain Relevance 0.51
We are able to describe relative but not absolute changes of IL-6 levels in response to pollution because we transformed the data to Z-scores in order to combine data from two separate studies.
Neg (not) Regulation (changes) of Transcription (levels) of IL-6
7) Confidence 0.26 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0.56 Pain Relevance 0.18
In the report by Warne [46], mRNA expressions of IL-6 and other cytokine and leukocyte markers were not altered in cachectic patients with cancer, and no major fat cell death was present either.
Neg (not) Regulation (altered) of Transcription (expressions) of IL-6 in fat cell associated with cancer, obesity, death and cytokine
8) Confidence 0.23 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.76 Pain Relevance 0.23
B, at physiologically relevant concentrations, thus reducing the production of some of its transcripts, namely IL-6 and TNF-?
Regulation (namely) of Transcription (transcripts) of IL-6
9) Confidence 0.13 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 0.68 Pain Relevance 0.12
These include cytokines/ growth factors and their receptors (e.g. platelet-derived growth factor-alpha chain, IL-6, epidermal growth factor, insulin-like growth factor, hepatocyte growth factor and its receptor); transcription factors (e.g.
Regulation (platelet) of Transcription (derived) of IL-6 in hepatocyte associated with cytokine
10) Confidence 0.07 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64845 Disease Relevance 0.73 Pain Relevance 0.26

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