INT6473

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Context Info
Confidence 0.70
First Reported 1988
Last Reported 2011
Negated 8
Speculated 2
Reported most in Abstract
Documents 204
Total Number 206
Disease Relevance 117.23
Pain Relevance 50.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
chondrocytes 16
astrocytes 12
macrophages 10
monocytes 10
spinal cord 8
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2240 100.00 Very High Very High Very High
cytokine 1979 100.00 Very High Very High Very High
Arthritis 806 100.00 Very High Very High Very High
metalloproteinase 372 100.00 Very High Very High Very High
antagonist 303 100.00 Very High Very High Very High
mu opioid receptor 7 100.00 Very High Very High Very High
Restless leg syndrome 4 100.00 Very High Very High Very High
cINOD 182 99.98 Very High Very High Very High
Morphine 10 99.98 Very High Very High Very High
intrathecal 2 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2615 100.00 Very High Very High Very High
Disease 2018 100.00 Very High Very High Very High
Arthritis 707 100.00 Very High Very High Very High
Cancer 402 100.00 Very High Very High Very High
Necrosis 193 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 70 100.00 Very High Very High Very High
Intervertebral Disk Displacement 10 100.00 Very High Very High Very High
Hypercalcemia 58 99.96 Very High Very High Very High
Coronary Artery Disease 67 99.92 Very High Very High Very High
Rickets 2 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No drug tested induced, by itself, the production of IL-1 inhibitor or enhanced the production of IL-1 inhibitor.
Positive_regulation (induced) of Gene_expression (production) of IL-1
1) Confidence 0.70 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.20 Pain Relevance 0.35
No drug tested induced, by itself, the production of IL-1 inhibitor or enhanced the production of IL-1 inhibitor.
Neg (No) Positive_regulation (enhanced) of Gene_expression (production) of IL-1
2) Confidence 0.70 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.19 Pain Relevance 0.34
Above 5 microM, the non-steroidal anti-inflammatory compounds indomethacin and BW755C increased IL-1 beta biosynthesis.
Positive_regulation (increased) of Gene_expression (biosynthesis) of IL-1 beta associated with inflammation
3) Confidence 0.69 Published 1989 Journal Drugs Exp Clin Res Section Abstract Doc Link 2513175 Disease Relevance 0.22 Pain Relevance 0.27
Sodium salicylate and indomethacin did not share this action, and demonstrated either no effect or enhancement of IL-1 beta synthesis, respectively, in the presence of LPS.
Positive_regulation (enhancement) of Gene_expression (synthesis) of IL-1 beta
4) Confidence 0.69 Published 1993 Journal Agents Actions Suppl. Section Abstract Doc Link 8456629 Disease Relevance 0.19 Pain Relevance 0.36
IL-1 beta production was also elevated, but this remained constant.
Positive_regulation (elevated) of Gene_expression (production) of IL-1 beta
5) Confidence 0.68 Published 1995 Journal J. Dent. Res. Section Abstract Doc Link 7560389 Disease Relevance 0.24 Pain Relevance 0.24
The increase in IL-1 beta production was also significantly inhibited by laser irradiation, although the inhibition was only partial.
Positive_regulation (increase) of Gene_expression (production) of IL-1 beta
6) Confidence 0.68 Published 1995 Journal J. Dent. Res. Section Abstract Doc Link 7560389 Disease Relevance 0.17 Pain Relevance 0.17
Based on the in vitro observation that VNTR allele 2 has been associated with a decreased production of IL-1ra [14,58]; and increased production of IL-1?
Positive_regulation (increased) of Gene_expression (production) of IL-1
7) Confidence 0.67 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.42 Pain Relevance 0.12
The impact-loading induced the expression of IL-1beta immunohistochemically and prominently up-regulated IL-1alpha and IL-1beta mRNA levels in subchondral bone.
Positive_regulation (induced) of Gene_expression (expression) of IL-1beta
8) Confidence 0.67 Published 2009 Journal Ann Biomed Eng Section Abstract Doc Link 19381811 Disease Relevance 0.36 Pain Relevance 0.26
The cellular production of IL-1beta, a cytokine implicated in a variety of inflammatory diseases, requires cleavage of its precursor (proIL-1beta) at an Asp-X site by interleukin-1beta-converting enzyme (ICE, recently termed caspase-1).
Positive_regulation (requires) of Gene_expression (production) of IL-1beta in cleavage associated with inflammation, disease and cytokine
9) Confidence 0.67 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.20 Pain Relevance 0.14
These results suggest that the TMJ subjected to impact-loading can increase directly IL-1beta synthesis in the subchondral region, subsequently altering the metabolism of adjacent cartilage and may eventually resulting in the onset and progression of TMJ-OA.
Positive_regulation (increase) of Gene_expression (synthesis) of IL-1beta in TMJ associated with snapping jaw and osteoarthritis
10) Confidence 0.67 Published 2009 Journal Ann Biomed Eng Section Abstract Doc Link 19381811 Disease Relevance 0.29 Pain Relevance 0.29
We confirmed a significant decrease in type II collagen and aggrecan mRNA expressions in chondrocytes by co-culture with osteoblasts after impact-loading, and significant increase in mRNA and protein expressions of IL-1beta in subchondral osteoblasts from impact-loaded subchondral bone.
Positive_regulation (increase) of Gene_expression (expressions) of IL-1beta in osteoblasts
11) Confidence 0.67 Published 2009 Journal Ann Biomed Eng Section Abstract Doc Link 19381811 Disease Relevance 0.36 Pain Relevance 0.31
Hyperthermia significantly increased the production of IL-6 (p = 0.049) but not IL-1beta and significantly increased mortality.
Positive_regulation (increased) of Gene_expression (production) of IL-1beta associated with fever
12) Confidence 0.67 Published 2002 Journal Pediatr. Res. Section Abstract Doc Link 12438666 Disease Relevance 0.71 Pain Relevance 0.27
IL-1beta RNA and protein expression were also elevated at 3 h after TBI, but remained so only for 48 h.
Positive_regulation (elevated) of Gene_expression (expression) of IL-1 associated with brain injury
13) Confidence 0.67 Published 2005 Journal J. Neurotrauma Section Abstract Doc Link 16083355 Disease Relevance 1.14 Pain Relevance 0.19
The finding that glial activation and enhanced IL-1beta expression are observed in the spinal cord after root injury supports a central, neuroimmune component in the generation of lumbar radiculopathy.
Positive_regulation (enhanced) of Gene_expression (expression) of IL-1beta in spinal cord
14) Confidence 0.67 Published 2000 Journal Spine Section Body Doc Link 10806496 Disease Relevance 0 Pain Relevance 0
Standard 3 h ischemia-reperfusion of the stomach produced numerous gastric lesions, decreased gastric blood flow and mucosal prostaglandin E2 generation and increased expression and plasma release of interleukin-1beta and tumor necrosis factor-alpha (TNF-alpha).
Positive_regulation (increased) of Gene_expression (expression) of interleukin-1beta in plasma associated with necrosis, cancer and ischemia
15) Confidence 0.67 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363968 Disease Relevance 1.07 Pain Relevance 0.47
In addition, spinal IL-1beta protein expression was increased bilaterally in the superficial layer of the dorsal horn and cell nuclei of the ventral horns in the ligature treated groups as compared with the sham group.
Positive_regulation (increased) of Gene_expression (expression) of IL-1beta in ventral
16) Confidence 0.67 Published 2000 Journal Spine Section Body Doc Link 10806496 Disease Relevance 0 Pain Relevance 0
Potential mechanisms that were put forward to explain the relationship between periodontal disease (PD) and PTLBW infant delivery was that periodontal infection serves as a chronic reservoir of lipopolysaccharide (LPS) which are responsible for the production of interleukin-1beta (IL-1?)
Positive_regulation (responsible) of Gene_expression (production) of interleukin-1beta in reservoir associated with periodontal disease and infection
17) Confidence 0.67 Published 2007 Journal BMC Oral Health Section Body Doc Link PMC1924845 Disease Relevance 0.89 Pain Relevance 0
Administration of MDP significantly increased the IL-1beta production (p = 0.006) but not IL-6.
Neg (not) Positive_regulation (increased) of Gene_expression (production) of IL-1beta
18) Confidence 0.67 Published 2002 Journal Pediatr. Res. Section Abstract Doc Link 12438666 Disease Relevance 0.57 Pain Relevance 0.23
In their initial as well as in subsequent papers, Giulian and colleagues emphasized the production of a prototypical proinflammatory cytokine, interleukin-1 (IL-1), by ameboid microglia (so-called because of their resemblance to macrophages), which was reaffirmed by Hetier et al. (1988) just a couple of years later by showing that IL-1 mRNA synthesis was induced in these cultured cells following their stimulation with bacterial lipopolysaccharide (LPS).
Positive_regulation (induced) of Gene_expression (synthesis) of IL-1 mRNA in macrophages associated with cytokine
19) Confidence 0.65 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890154 Disease Relevance 0.26 Pain Relevance 0.08
In the current study, a marked increase in the proportion of cells immunoreactive for IL-1 were found in degenerate than in non-degenerate IVDs, but no similar increase in IL-1Ra-immunopositive cells was observed, indicating an imbalance in the local production of IL-1 and IL-1Ra and failure of the normal compensatory mechanism associated with increasing local production of IL-1.
Positive_regulation (increasing) of Gene_expression (production) of IL-1
20) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.23 Pain Relevance 0.07

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