INT64734

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 6.81
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
NFAT 2
embryonic stages 1
HeLa 1
Mpz (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 6 99.60 Very High Very High Very High
Nicotine 3 99.02 Very High Very High Very High
Pain 4 98.98 Very High Very High Very High
qutenza 3 98.98 Very High Very High Very High
nociceptor 3 98.98 Very High Very High Very High
Analgesic 1 98.98 Very High Very High Very High
Dopamine 32 98.96 Very High Very High Very High
gABA 11 97.08 Very High Very High Very High
Clonidine 3 94.72 High High
Peripheral nervous system 10 83.84 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 363 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 56 99.96 Very High Very High Very High
Nociception 9 99.74 Very High Very High Very High
Teratocarcinoma 2 99.44 Very High Very High Very High
Toxicity 65 99.22 Very High Very High Very High
Death 258 98.36 Very High Very High Very High
Adhesions 12 97.12 Very High Very High Very High
Disease 338 92.16 High High
Stress 68 87.72 High High
Neuropathic Pain 19 79.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, NFAT c4 complexes with Sox-10, a transcription factor required for myelination [17], to activate the promoter and myelin-specific enhancer of the Krox-20 gene, which globally regulates peripheral myelination [11,18-20], and also with the promoter of the myelin protein zero (P0) gene, all of which underline the involvement of NFAT proteins in myelination.
Positive_regulation (activate) of P0 in NFAT
1) Confidence 0.67 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0 Pain Relevance 0.06
On the contrary, the treatment with MK 801, although uneffective in preventing the long-term MPTP-induced striatal DA decrease, causes an increase in the striatal amount of MPP+.
Positive_regulation (increase) of MPP associated with parkinson's disease
2) Confidence 0.61 Published 1996 Journal Neurodegeneration Section Abstract Doc Link 8819133 Disease Relevance 0.65 Pain Relevance 0.17
Here, we show that GABA(B1)-deficient mice exhibit morphological and molecular changes in peripheral myelin, including an increase in the number of irregular fibers and increases in the expression levels of the myelin proteins PMP22 and P0.
Positive_regulation (increases) of P0 associated with gaba
3) Confidence 0.49 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18206390 Disease Relevance 0.08 Pain Relevance 0.62
Similarly, the MPTP toxicity enhancers, DDC and acetaldehyde, both increase striatal MPP+ levels, as previously reported.
Positive_regulation (increase) of MPP associated with parkinson's disease and toxicity
4) Confidence 0.47 Published 1996 Journal Neurodegeneration Section Abstract Doc Link 8819133 Disease Relevance 0.58 Pain Relevance 0.14
HeLa cells tranfected with two late onset and two early onset MPZ mutations showed that the two late onset mutations had normal transportation of the P0 to the cell membrane and moderately reduced MPZ-mediated intercellular adhesion, while the two early onset mutations had different patterns [23].
Positive_regulation (transportation) of P0 in HeLa associated with adhesions
5) Confidence 0.44 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2861067 Disease Relevance 0.48 Pain Relevance 0
In a similar way, the administration of nicotine in combination with MPTP produces a significant increase in the levels of striatal MPP+, which does not elicit any effect on striatal DA.
Positive_regulation (increase) of MPP associated with parkinson's disease and nicotine
6) Confidence 0.41 Published 1996 Journal Neurodegeneration Section Abstract Doc Link 8819133 Disease Relevance 0.66 Pain Relevance 0.18
is required for the MPP+-induced alterations of the mitochondrial membrane potential.
Positive_regulation (required) of MPP+-induced
7) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.08 Pain Relevance 0
As shown by fluorimetric and Western blot analysis, pre-incubation with 25 mM LiCl prevented the MPP+-induced caspase-9 and -3 activation (Figure 3A–3E).
Positive_regulation (activation) of MPP+-induced
8) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.05 Pain Relevance 0
TSM1 and primary cultured neurons were incubated for 15 h with 400 µM MPP+ in the presence of GSK-3?
Positive_regulation (incubated) of MPP in neurons
9) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.48 Pain Relevance 0.07
inhibitors prevented MPP+-induced caspase-9 and caspase-3 activation
Positive_regulation (activation) of MPP+-induced
10) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.26 Pain Relevance 0
was significantly increased after the MPP+ treatment (Figure 4B and 4C).
Positive_regulation (increased) of MPP
11) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0 Pain Relevance 0
Furthermore, NFAT c4 complexes with Sox-10, a transcription factor required for myelination [17], to activate the promoter and myelin-specific enhancer of the Krox-20 gene, which globally regulates peripheral myelination [11,18-20], and also with the promoter of the myelin protein zero (P0) gene, all of which underline the involvement of NFAT proteins in myelination.
Positive_regulation (activate) of myelin protein zero in NFAT
12) Confidence 0.32 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0 Pain Relevance 0.05
is a critical mediator of MPTP/MPP+-induced neurotoxicity through its ability to regulate mitochondrial functions.
Positive_regulation (mediator) of MPP+-induced associated with parkinson's disease and drug induced neurotoxicity
13) Confidence 0.20 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2675062 Disease Relevance 0.89 Pain Relevance 0
Interestingly, in homozygous mutant, there was a delay in this shift; isoforms containing exon 10b remained upregulated longer (compare at P0) during development.
Positive_regulation (upregulated) of P0
14) Confidence 0.13 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2916854 Disease Relevance 0.06 Pain Relevance 0
Therefore, we sought to determine whether SN is able to reduce MPP+-induced ROS production.
Spec (whether) Positive_regulation (induced) of MPP+-induced
15) Confidence 0.11 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2064906 Disease Relevance 0.47 Pain Relevance 0.03
MPP+ is also concentrated into DAergic neurons via DA transporter.
Positive_regulation (concentrated) of MPP in neurons associated with dopamine
16) Confidence 0.11 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.79 Pain Relevance 0.05
We reported that MPP+ induced in NT2 human teratocarcinoma a marked increase in ubiquitinylated protein levels, free radicals generation and a decrease in ATP levels.
Positive_regulation (induced) of MPP associated with teratocarcinoma
17) Confidence 0.10 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.58 Pain Relevance 0
The number of shared genes increases from the embryonic stages (211&225 genes respectively) to 325 genes at birth (P0), indicating that KK1 cells have transcriptional profile more like that of a mature granulosa cell in vivo.
Positive_regulation (increases) of P0 in embryonic stages
18) Confidence 0.05 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.18 Pain Relevance 0
Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice.
Positive_regulation (activation) of peripheral protein kinase associated with nociception and analgesic
19) Confidence 0.04 Published 2005 Journal Pain Section Title Doc Link 16099101 Disease Relevance 0.52 Pain Relevance 1.17

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