INT6475

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.19
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (TNFRSF1B) extracellular region (TNFRSF1B) plasma membrane (TNFRSF1B)
Anatomy Link Frequency
plasma 3
neurons 1
TNFRSF1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 211 97.52 Very High Very High Very High
cytokine 321 96.08 Very High Very High Very High
antagonist 4 93.80 High High
carbamazepine 10 92.08 High High
Serotonin 66 84.28 Quite High
Endep 5 82.04 Quite High
depression 115 79.92 Quite High
antidepressant 50 69.64 Quite High
headache 2 68.00 Quite High
Multiple sclerosis 30 60.24 Quite High
Disease Link Frequency Relevance Heat
Necrosis 23 99.82 Very High Very High Very High
Cancer 30 99.64 Very High Very High Very High
Pressure Volume 2 Under Development 2 98.72 Very High Very High Very High
Solid Tumor 1 98.56 Very High Very High Very High
INFLAMMATION 217 97.52 Very High Very High Very High
Injury 33 95.64 Very High Very High Very High
Sleep Disorders 86 93.64 High High
Sepsis 6 90.76 High High
Depression 145 90.32 High High
Obesity 95 85.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
upregulation of some genes, such as TNFR-1 and TNFR-2, TRAF-6 and IGFBP-6, whose transcription is under the control of NF-?
Positive_regulation (upregulation) of TNFR-2
1) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
It has been shown that levels of the p75 neurotrophin receptors (NTR) are upregulated in neurons, while there is a persistent down-regulation of tyrosine-related kinase receptors (TrkRs) in the injury vicinity [27].
Positive_regulation (upregulated) of p75 in neurons associated with injury
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.38 Pain Relevance 0
and sTNF-R p75 levels have already been shown to be significantly increased cross-sectionally in patients treated with lithium [23].
Positive_regulation (increased) of sTNF-R p75
3) Confidence 0.20 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 0.64 Pain Relevance 0.20
In narcoleptic patients, soluble TNF receptor (sTNF-R) p75 plasma levels have been shown to be elevated, suggesting a functional role of the TNF-?
Positive_regulation (elevated) of p75 in plasma
4) Confidence 0.15 Published 2008 Journal Current Neuropharmacology Section Abstract Doc Link PMC2687935 Disease Relevance 0.52 Pain Relevance 0.12
A phase I trial of intramuscularly administered recombinant human tumor necrosis factor (rTNF) was conducted in 19 adult patients with advanced solid tumors.
Positive_regulation (conducted) of rTNF associated with necrosis, cancer and solid tumor
5) Confidence 0.14 Published 1989 Journal J. Clin. Oncol. Section Abstract Doc Link 2918329 Disease Relevance 1.14 Pain Relevance 0.07
It was concluded that narcoleptic patients show increased plasma levels of sTNF-R p75 suggesting a functional alteration of the TNF-?
Positive_regulation (increased) of sTNF-R p75 in plasma
6) Confidence 0.13 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 0.57 Pain Relevance 0.08
In a sample of 30 narcoleptic patients in comparison to 120 gender- and age-matched and 101 gender-, BMI- and age-matched randomly selected normal controls, sTNF-R p75 levels were consistently elevated in the narcoleptic patients, even if compared to gender-, BMI- and age-matched counterparts.
Positive_regulation (elevated) of sTNF-R p75
7) Confidence 0.13 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 0.96 Pain Relevance 0.08
In narcoleptic patients, soluble TNF receptor (sTNF-R) p75 plasma levels have been shown to be elevated, suggesting a functional role of the TNF-?
Positive_regulation (elevated) of soluble TNF receptor in plasma
8) Confidence 0.13 Published 2008 Journal Current Neuropharmacology Section Abstract Doc Link PMC2687935 Disease Relevance 0.53 Pain Relevance 0.12
Although levels of IL-1Ra and sTNFR are elevated in patients on HD, these levels reflect the host response to inflammation.
Positive_regulation (elevated) of sTNFR associated with inflammation
9) Confidence 0.03 Published 1992 Journal Kidney Int. Suppl. Section Abstract Doc Link 1328757 Disease Relevance 0.44 Pain Relevance 0.25

General Comments

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