INT64756

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.03
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 7
Disease Relevance 0
Pain Relevance 4.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi1) carbohydrate metabolic process (Gpi1) cytoplasm (Gpi1)
cytosol (Gpi1) extracellular space (Gpi1) extracellular region (Gpi1)
Anatomy Link Frequency
NK cell 6
oh (Mus musculus)
Gpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 21 99.92 Very High Very High Very High
Catecholamine 21 99.34 Very High Very High Very High
antagonist 21 99.24 Very High Very High Very High
gABA 28 98.66 Very High Very High Very High

|}

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chemical sympathectomy significantly reduced the suppression of NK cell activity by EtOH.
EtOH Negative_regulation (suppression) of NK in NK cell
1) Confidence 0.03 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819520 Disease Relevance 0 Pain Relevance 0.57
The opioid antagonist naltrexone (delivered by a timed-release pellet) did not block suppression of NK cell activity by EtOH.
EtOH Negative_regulation (suppression) of NK in NK cell associated with antagonist and opioid
2) Confidence 0.03 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819520 Disease Relevance 0 Pain Relevance 0.66
The glucocorticoid antagonist RU 486 (mifepristone) did not affect EtOH-induced suppression of NK cell activity, and exogenous corticosterone only marginally suppressed NK cell activity.
EtOH Negative_regulation (suppression) of NK in NK cell associated with antagonist
3) Confidence 0.03 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819520 Disease Relevance 0 Pain Relevance 0.61
Involvement of GABA-A receptors was suggested by the ability of Ro15-4513 to decrease EtOH-induced NK suppression.
EtOH Negative_regulation (suppression) of NK associated with gaba
4) Confidence 0.03 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819520 Disease Relevance 0 Pain Relevance 0.63
Thus glucocorticoids and opioids are not the major causes of EtOH-induced suppression of NK cell activity, and catecholamines seem only partially responsible for this effect.
EtOH Negative_regulation (suppression) of NK in NK cell associated with catecholamine and opioid
5) Confidence 0.03 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819520 Disease Relevance 0 Pain Relevance 0.66
The catecholamine antagonists phentolamine, nadolol and propranolol (delivered by a timed-release pellet) respectively exacerbated, partially blocked and had no effect on EtOH-induced suppression of NK cell activity.
EtOH Negative_regulation (suppression) of NK in NK cell associated with antagonist and catecholamine
6) Confidence 0.03 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819520 Disease Relevance 0 Pain Relevance 0.55
In this study, the role of catecholamines, glucocorticoids and opioids in EtOH-induced suppression of NK cell activity in mice was evaluated.
EtOH Negative_regulation (suppression) of NK in NK cell associated with catecholamine and opioid
7) Confidence 0.03 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819520 Disease Relevance 0 Pain Relevance 0.40

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox