INT6476

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 18.22
Pain Relevance 5.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (TNFRSF1B) extracellular region (TNFRSF1B) plasma membrane (TNFRSF1B)
Anatomy Link Frequency
plasma 2
endothelial cells 2
lungs 2
horns 1
DAN 1
TNFRSF1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 19 98.90 Very High Very High Very High
Etanercept 247 98.84 Very High Very High Very High
Inflammation 386 97.60 Very High Very High Very High
cytokine 309 96.08 Very High Very High Very High
rheumatoid arthritis 299 95.60 Very High Very High Very High
Bioavailability 2 95.28 Very High Very High Very High
antagonist 17 94.64 High High
Infliximab 111 92.96 High High
Inflammatory response 14 91.44 High High
Inflammatory mediators 8 89.52 High High
Disease Link Frequency Relevance Heat
Cancer 127 100.00 Very High Very High Very High
Necrosis 47 100.00 Very High Very High Very High
Apoptosis 72 99.60 Very High Very High Very High
Pressure Volume 2 Under Development 11 99.56 Very High Very High Very High
Pancreatic Cancer 8 99.32 Very High Very High Very High
Hypothermia 138 99.08 Very High Very High Very High
Death 22 98.48 Very High Very High Very High
Dermatitis 6 97.60 Very High Very High Very High
Injury 102 97.36 Very High Very High Very High
Disease 221 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacokinetic studies have shown a relatively rapid clearance following intravenous infusion with a half-life of 15 to 30 min and dose-dependent pharmacokinetics. rTNF can be detected in the serum following intramuscular or subcutaneous injection at only relatively high doses, suggesting a decreased bioavailability with the routes of administration.
Gene_expression (detected) of rTNF associated with bioavailability
1) Confidence 0.67 Published 1992 Journal Immunol. Ser. Section Abstract Doc Link 1550875 Disease Relevance 0.53 Pain Relevance 0.18
B did not take place in the lungs of double (p55p75) TNF?
Gene_expression (double) of p75 in lungs
2) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.23 Pain Relevance 0.10
Moreover, pancreatic cancer cell lines were used to validate if the effects of NGF on pancreatic cancer cell growth are dependent on the expression levels and the balance of TrkA and P75 receptors.
Gene_expression (expression) of P75 associated with nerve growth factor and pancreatic cancer
3) Confidence 0.65 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15944784 Disease Relevance 1.00 Pain Relevance 0.42
B did not take place in the lungs of double (p55p75) TNF?
Gene_expression (lungs) of p75 in lungs
4) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.23 Pain Relevance 0.10
TNF interacts with two different receptors, designated TNFR1 and TNFR2, which are differentially expressed on cells and tissues and initiate both distinct and overlapping signal transduction pathways.
Gene_expression (expressed) of TNFR2
5) Confidence 0.61 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18161752 Disease Relevance 0.98 Pain Relevance 0.20
expression: Etanercept, a recombinant fusion protein, combining extracellular human p75 TNF receptors with the Fc domain of a human IgG1, neutralizing TNF-?
Gene_expression (receptors) of p75 associated with etanercept
6) Confidence 0.37 Published 2010 Journal Middle East African Journal of Ophthalmology Section Body Doc Link PMC2991444 Disease Relevance 1.14 Pain Relevance 0.35
It was concluded that narcoleptic patients show increased plasma levels of sTNF-R p75 suggesting a functional alteration of the TNF-?
Gene_expression (levels) of sTNF-R p75 in plasma
7) Confidence 0.22 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 0.57 Pain Relevance 0.08
Human cells (Fig. 4a) within the ventral horns double stained with Isl-1 (Fig. 4b), p75 (Fig. 4c; p75 in red, human nuclei in green), neurofilament or ChAT (Fig. 4d; ChAT in blue, human nuclei in brown), consistent with a MN lineage of mixed maturation state.
Gene_expression (stained) of p75 in horns
8) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912300 Disease Relevance 0.60 Pain Relevance 0.08
TNF-R p55 is expressed in most tissues, whereas expression of TNF-R p75 is highly regulated and typically found in cells of the immune system.
Gene_expression (expression) of TNF-R p75 in immune system
9) Confidence 0.19 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 1.30 Pain Relevance 0.30
Etanercept is a dimeric human tumor necrosis factor receptor (TNFR) p75-Fc fusion protein made of 2 extra-cellular domains of the human 75 kD (p75) TNFR linked by the constant Fc portion of human immunoglobulin 1 (IgG1).
Gene_expression (made) of p75 associated with necrosis, cancer and etanercept
10) Confidence 0.19 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936291 Disease Relevance 1.03 Pain Relevance 0.65
Mutations in the TNF1 receptor, which is widely distributed on both immune and nonimmune cells, were shown in six families.
Gene_expression (distributed) of TNF1 receptor
11) Confidence 0.15 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564298 Disease Relevance 1.77 Pain Relevance 0.09
The TNF receptors p55 and p75 are expressed by endothelial cells and a variety of other cell types in the lining and sublining layers [99,103].
Gene_expression (expressed) of p75 in endothelial cells
12) Confidence 0.13 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.67 Pain Relevance 0.53
However, much less is known about plasma levels of its soluble receptors sTNF-R p55 and sTNF-R p75.
Gene_expression (levels) of sTNF-R p75 in plasma
13) Confidence 0.07 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 1.58 Pain Relevance 0.38
The biotechnological production of human recombinant tumour necrosis factor (rHuTNF) makes this drug available for clinical application.
Gene_expression (production) of rHuTNF associated with necrosis and cancer
14) Confidence 0.07 Published 1990 Journal Geburtshilfe Frauenheilkd Section Abstract Doc Link 2177016 Disease Relevance 0.88 Pain Relevance 0
One is the ubiquitously expressed TNF-R1 (synonyms, p55 and CD120a) and the other one is TNF-R2 known also as p75 or CD120b.
Gene_expression (expressed) of TNF-R2
15) Confidence 0.07 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727880 Disease Relevance 0.45 Pain Relevance 0.36
One is the ubiquitously expressed TNF-R1 (synonyms, p55 and CD120a) and the other one is TNF-R2 known also as p75 or CD120b.
Gene_expression (synonyms) of TNF-R2
16) Confidence 0.07 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727880 Disease Relevance 0.45 Pain Relevance 0.36
TNF-R2 is predominantly found on hematopoietic and endothelial cells and crucially implicated in the TNF-?
Gene_expression (found) of TNF-R2 in endothelial cells
17) Confidence 0.06 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727880 Disease Relevance 0.53 Pain Relevance 0.42
Although levels of IL-1Ra and sTNFR are elevated in patients on HD, these levels reflect the host response to inflammation.
Gene_expression (levels) of sTNFR associated with inflammation
18) Confidence 0.03 Published 1992 Journal Kidney Int. Suppl. Section Abstract Doc Link 1328757 Disease Relevance 0.44 Pain Relevance 0.25
Hypothermia also suppresses apoptosis by down regulating expression of TNF receptor (TNFR1) [102] and its associated pro-death ligand, apoptosis stimulating fragment (Fas) protein.
Gene_expression (expression) of TNF receptor associated with hypothermia, apoptosis and death
19) Confidence 0.02 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.79 Pain Relevance 0.20
They include the paired box 7 (PAX7) gene encoding a transcriptional factor expressed in the neural tube which is regulated by notochord specific signals [76], the differentially screening-selected gene aberrant in neuroblastoma (DAN), involved in the negative regulation of cell proliferation [77], the Dishevelled 1 gene (DVL1), a key factor in Wnt signalling expressed in the neural tube [78] and a few genes belonging to the tumour necrosis factor receptor superfamily (TNFRSF-1B, -8, -9, -14), the DNA fragmentation factor (DFF-A and- B) and TP73 [UCSC], all acting in apoptotic pathways.
Gene_expression (expressed) of TNFRSF-1B in DAN associated with necrosis, neuroblastoma, cancer and apoptosis
20) Confidence 0.01 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 1.11 Pain Relevance 0

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