INT64762

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Context Info
Confidence 0.71
First Reported 1996
Last Reported 1997
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Uggt1) protein folding (Uggt1) transferase activity, transferring glycosyl groups (Uggt1)
endoplasmic reticulum (Uggt1)
Anatomy Link Frequency
liver 1
Uggt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 17 99.64 Very High Very High Very High
Opioid 3 93.80 High High
Buprenorphine 1 85.36 High High
narcan 1 62.80 Quite High
antagonist 1 61.12 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of two UDP-glucuronosyltransferase isoforms sensitive to phenobarbital that are involved in morphine glucuronidation: production of isoform-selective antipeptide antibodies toward UGT1.1r and UGT2B1.
Gene_expression (production) of UGT1 associated with morphine
1) Confidence 0.71 Published 1997 Journal Drug Metab. Dispos. Section Title Doc Link 9029046 Disease Relevance 0 Pain Relevance 0.66
The proteins have been identified as the gene products of UGT2B1 and UGT1.1r.
Gene_expression (products) of UGT1
2) Confidence 0.66 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8820424 Disease Relevance 0 Pain Relevance 0.47
However, UGT1.1r is not present in the liver from Gunn rats.
Neg (not) Gene_expression (present) of UGT1 in liver
3) Confidence 0.55 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9029046 Disease Relevance 0 Pain Relevance 0.65

General Comments

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