INT6477

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Context Info
Confidence 0.77
First Reported 1992
Last Reported 2010
Negated 2
Speculated 7
Reported most in Abstract
Documents 213
Total Number 220
Disease Relevance 114.69
Pain Relevance 58.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN) extracellular region (IL1RN) plasma membrane (IL1RN)
nucleus (IL1RN) intracellular (IL1RN) cytoplasm (IL1RN)
Anatomy Link Frequency
plasma 10
blood 7
IVD 6
tear 5
synovial fluid 5
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2725 100.00 Very High Very High Very High
cytokine 2361 100.00 Very High Very High Very High
antagonist 874 100.00 Very High Very High Very High
Pain 219 100.00 Very High Very High Very High
metalloproteinase 266 99.92 Very High Very High Very High
cINOD 90 99.92 Very High Very High Very High
Neuritis 14 99.92 Very High Very High Very High
rheumatoid arthritis 774 99.88 Very High Very High Very High
Central nervous system 19 99.78 Very High Very High Very High
Inflammatory response 102 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2908 100.00 Very High Very High Very High
Rheumatoid Arthritis 999 100.00 Very High Very High Very High
Cancer 265 100.00 Very High Very High Very High
Pain 214 100.00 Very High Very High Very High
Necrosis 176 100.00 Very High Very High Very High
Sprains And Strains 1287 99.98 Very High Very High Very High
Experimental Autoimmune Neuritis 14 99.92 Very High Very High Very High
Critical Illness 148 99.84 Very High Very High Very High
Skin Diseases 9 99.80 Very High Very High Very High
Adenocarcinoma 90 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1ra protein is produced by many cells that can synthesize IL-1?
Gene_expression (produced) of IL-1ra
1) Confidence 0.77 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.96 Pain Relevance 0.36
Based on the in vitro observation that VNTR allele 2 has been associated with a decreased production of IL-1ra [14,58]; and increased production of IL-1?
Gene_expression (production) of IL-1ra
2) Confidence 0.77 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.42 Pain Relevance 0.12
Interestingly, Mahoney and colleagues [9] demonstrated that elevated gene expression of IL-1RI is induced in skeletal muscle after eccentric exercise.
Gene_expression (expression) of IL-1RI in skeletal muscle
3) Confidence 0.77 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.88 Pain Relevance 0.19
The effects of nonsteroidal anti-inflammatory drugs (NSAIDs), mofezolac, indomethacin, sodium diclofenac, and zaltoprofen, on the production of interleukin-1 receptor antagonist (IL-1ra) were examined in cultured human peripheral blood mononuclear cells (PBMC).
Gene_expression (production) of IL-1ra in mononuclear cells associated with inflammation, antagonist, cinod and diclofenac
4) Confidence 0.77 Published 1997 Journal Prostaglandins Section Abstract Doc Link 9491209 Disease Relevance 0.17 Pain Relevance 0.58
Since IL-1ra suppresses the function of IL-1, a pro-inflammatory cytokine, the stimulatory effect of such NSAIDs as mofezolac on IL-1ra production could also be one of the mechanisms involved in its anti-inflammatory and antinociceptive actions.
Gene_expression (production) of IL-1ra associated with inflammation, cinod, antinociceptive and cytokine
5) Confidence 0.77 Published 1997 Journal Prostaglandins Section Abstract Doc Link 9491209 Disease Relevance 0.34 Pain Relevance 0.76
The effects of nonsteroidal anti-inflammatory drugs (NSAIDs), mofezolac, indomethacin, sodium diclofenac, and zaltoprofen, on the production of interleukin-1 receptor antagonist (IL-1ra) were examined in cultured human peripheral blood mononuclear cells (PBMC).
Gene_expression (production) of interleukin-1 receptor antagonist in mononuclear cells associated with inflammation, antagonist, cinod and diclofenac
6) Confidence 0.77 Published 1997 Journal Prostaglandins Section Abstract Doc Link 9491209 Disease Relevance 0.17 Pain Relevance 0.58
The production of IL-1 and IL-1ra is regulated by genotypic and nongenotypic factors and is different between men and women.
Gene_expression (production) of IL-1ra
7) Confidence 0.77 Published 2007 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 18052726 Disease Relevance 0.10 Pain Relevance 0.19
Intra-articular gene expression of IL-1Ra has shown promising results in animal models to provide symptomatic improvement and minimize osteoarthritic changes.
Gene_expression (expression) of IL-1Ra in articular associated with osteoarthritis
8) Confidence 0.75 Published 2010 Journal Expert Rev Clin Immunol Section Abstract Doc Link 20441419 Disease Relevance 1.09 Pain Relevance 0.54
Further development and progression to clinically manifest disease was accompanied by SC-specific expression of IL-1Ra.
Gene_expression (expression) of IL-1Ra associated with disease
9) Confidence 0.74 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11311332 Disease Relevance 0.94 Pain Relevance 0.75
IL-1Ra was not detectable in SC at preclinical stage.
Neg (not) Gene_expression (detectable) of IL-1Ra
10) Confidence 0.74 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11311332 Disease Relevance 0.98 Pain Relevance 0.73
In contrast to piroxicam and aspirin, aceclofenac 10 microg/ml and TNF-alpha 10 ng/ml increased almost 46 times the basal amount of IL-1Ra produced by OA chondrocytes.
Gene_expression (produced) of IL-1Ra in chondrocytes
11) Confidence 0.73 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11764219 Disease Relevance 0.05 Pain Relevance 0
RESULTS: OA samples spontaneously produced higher levels of IL-1Ra than normal samples (130+/-2.3 vs 30+/-3.1 pg/mI).
Gene_expression (produced) of IL-1Ra
12) Confidence 0.73 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11764219 Disease Relevance 0.07 Pain Relevance 0
We investigated the possible effects of 3 different nonsteroidal antiinflammatory drugs (NSAID; aceclofenac, piroxicam, aspirin) on IL-1Ra and NO production in human articular chondrocytes.
Neg (NO) Gene_expression (production) of IL-1Ra in chondrocytes associated with aspirin, inflammation and cinod
13) Confidence 0.73 Published 2001 Journal J. Rheumatol. Section Abstract Doc Link 11764219 Disease Relevance 0.19 Pain Relevance 0.27
Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes.
Gene_expression (synthesis) of interleukin 1 receptor antagonist in articular associated with aspirin and antagonist
14) Confidence 0.73 Published 2001 Journal J. Rheumatol. Section Title Doc Link 11764219 Disease Relevance 0.09 Pain Relevance 0.31
In the study presented, cells of a herniated lumbar disc were cultivated in vitro and analysed for interleukin 1beta (IL-1beta) and interleukin 1 receptor antagonist (IL-1Ra) production.
Spec (analysed) Gene_expression (production) of interleukin 1 receptor associated with antagonist
15) Confidence 0.72 Published 1998 Journal Cytokine Section Abstract Doc Link 9770331 Disease Relevance 0.08 Pain Relevance 0.21
In the study presented, cells of a herniated lumbar disc were cultivated in vitro and analysed for interleukin 1beta (IL-1beta) and interleukin 1 receptor antagonist (IL-1Ra) production.
Spec (analysed) Gene_expression (production) of IL-1Ra associated with antagonist
16) Confidence 0.72 Published 1998 Journal Cytokine Section Abstract Doc Link 9770331 Disease Relevance 0.08 Pain Relevance 0.21
The objective of this study was the detection of IL-1beta and IL-1Ra secreted by herniated lumbar discal cells after discectomy.
Gene_expression (detection) of IL-1Ra in discal cells
17) Confidence 0.72 Published 1998 Journal Cytokine Section Abstract Doc Link 9770331 Disease Relevance 0.09 Pain Relevance 0.22
To identify and test a suitable method for delivering IL-1Ra long-term to the IVD, we have explored the use of cells engineered to over-express IL-1Ra.
Gene_expression (express) of IL-1Ra
18) Confidence 0.70 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.27 Pain Relevance 0.15
is IL-1ra, a naturally occurring inhibitor of IL-1?
Gene_expression (is) of IL-1ra
19) Confidence 0.67 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.66 Pain Relevance 0.37
We measured the in vitro production of IL-6, TNF alpha and IL-1RA by stimulated (phytohemagglutinin+lipopolysaccharide), diluted whole blood of 16 normal volunteers.
Gene_expression (production) of IL-1RA in blood
20) Confidence 0.67 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084220 Disease Relevance 0.16 Pain Relevance 0.58

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