INT64777

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Context Info
Confidence 0.38
First Reported 1995
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 17.40
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
smooth muscle cells 2
bar 1
cartilage 1
tendon 1
stellate cells 1
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 120 99.62 Very High Very High Very High
Osteoarthritis 194 99.10 Very High Very High Very High
tolerance 7 98.86 Very High Very High Very High
Inflammation 178 95.82 Very High Very High Very High
cytokine 95 95.64 Very High Very High Very High
Angina 1 93.24 High High
COX-2 inhibitor 15 92.72 High High
Neuritis 1 82.40 Quite High
cINOD 11 78.76 Quite High
imagery 10 77.20 Quite High
Disease Link Frequency Relevance Heat
Metastasis 113 99.64 Very High Very High Very High
Endometriosis (extended) 18 99.56 Very High Very High Very High
Frailty 93 99.48 Very High Very High Very High
Wrinkles 13 99.30 Very High Very High Very High
Osteoarthritis 116 99.10 Very High Very High Very High
Uterine Fibroids 240 99.00 Very High Very High Very High
Blister 1 98.80 Very High Very High Very High
Intervertebral Disk Degeneration 39 98.72 Very High Very High Very High
Rupture 79 98.56 Very High Very High Very High
Aging 37 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Predisposing mechanical or ischemic factors could modify tendon collagen composition, characterized by both increased amounts of types III and V fibrils and diminished synthesis of type I collagen, which leads to abnormal fibrillogenesis and production of less resistant fibers that are more susceptible to rupture.
Negative_regulation (diminished) of collagen in tendon associated with rupture
1) Confidence 0.38 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.42 Pain Relevance 0
A partial defect in type IV collagen, which is involved in repair of the basement membrane, may have played a role in the etiology of pneumothoraces in this patient.
Negative_regulation (defect) of collagen in basement membrane
2) Confidence 0.38 Published 1995 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 8822001 Disease Relevance 0.36 Pain Relevance 0.09
Control samples showed that type V deposited near the vessels only, while surgically obtained specimens displayed type V collagen surrounding other types of collagen fibers in thicker adventitial layers.
Negative_regulation (displayed) of collagen in vessels
3) Confidence 0.34 Published 2008 Journal Clinics Section Abstract Doc Link PMC2664193 Disease Relevance 0.49 Pain Relevance 0
The collagen fibers are infiltrated, impregnated, stabilized, and so prevented from collapsing.
Negative_regulation (impregnated) of collagen
4) Confidence 0.29 Published 2003 Journal Biomed Eng Online Section Body Doc Link PMC222922 Disease Relevance 0.08 Pain Relevance 0
EDTA-Fe-Na (ethylene diamine tetra acetic) can be used as an additive since it is suitable for the prevention of the denaturation of the collagen during and after demineralization.
Negative_regulation (prevention) of collagen
5) Confidence 0.29 Published 2003 Journal Biomed Eng Online Section Body Doc Link PMC222922 Disease Relevance 0.07 Pain Relevance 0
The collagen fibers are infiltrated, impregnated, stabilized, and so prevented from collapsing.
Negative_regulation (prevented) of collagen
6) Confidence 0.29 Published 2003 Journal Biomed Eng Online Section Body Doc Link PMC222922 Disease Relevance 0.08 Pain Relevance 0
TNF alpha increased collagen contractility in comparison to the un-stimulated collagen embedded hUtSMC cells, which was inhibited by indomethacin, while indomethacin alone significantly inhibited contraction.
Negative_regulation (inhibited) of collagen
7) Confidence 0.16 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2645409 Disease Relevance 0.20 Pain Relevance 0.03
Cell contractility was calculated over time, with the collagen gel contraction assay, utilising human primary uterine smooth muscle cells (hUtSMCs) and immortalised myometrial smooth muscle cells (hTERT-HM): a decrease in collagen gel area equated to an increase in contractility.
Negative_regulation (decrease) of collagen in smooth muscle cells
8) Confidence 0.16 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2645409 Disease Relevance 0.27 Pain Relevance 0.05
A bar chart representation from a separate experiment illustrated a 29.3% (P < 0.05) decrease in collagen gel area after thrombin application alone, at 1 hr 30 mins.
Negative_regulation (decrease) of collagen in bar
9) Confidence 0.16 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
Collagen denaturation epitopes
Negative_regulation (epitopes) of Collagen
10) Confidence 0.14 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.84 Pain Relevance 0.19
CONCLUSIONS: A massive increase in myofibroblast activity, compatible with the activation of stellate cells, is associated with the deposition of collagen types I and IV in the desmoplastic reaction around pancreatic adenocarcinomas.


Negative_regulation (deposition) of collagen in stellate cells
11) Confidence 0.11 Published 2002 Journal Surgery Section Body Doc Link 11854689 Disease Relevance 0.05 Pain Relevance 0
The main frequent changes observed among women aged between 30 and 60 years due to the natural and continuing aging process are the appearance of small wrinkles, atrophy of subcutaneous fat, and decreases in collagen and elastin production.
Negative_regulation (decreases) of collagen in fat associated with aging, wrinkles and frailty
12) Confidence 0.06 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946856 Disease Relevance 0.63 Pain Relevance 0.08
However, how defects in collagen I influence the development of disc degeneration is still unclear and needs further investigation.
Negative_regulation (defects) of collagen associated with intervertebral disk degeneration
13) Confidence 0.06 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.63 Pain Relevance 0
For the experiments, we used the collagen sponge gel with 50 nmol/l of ?
Negative_regulation (used) of collagen
14) Confidence 0.04 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0
L ratio was found, indicating that the net half-life of collagen is slightly decreased after the menopause [16].
Negative_regulation (decreased) of collagen associated with endometriosis (extended)
15) Confidence 0.04 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.61 Pain Relevance 0
Such a decrease in collagen type I half-life is likely to reflect a significant imbalance between anabolic and catabolic processes at the focal area of metastatic invasion [11].
Negative_regulation (decrease) of collagen
16) Confidence 0.04 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.44 Pain Relevance 0
, are involved in the pathogenesis of OA by metalloproteinase (MMP) upregulation and collagen downregulation.
Negative_regulation (downregulation) of collagen associated with metalloproteinase and osteoarthritis
17) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 1.08 Pain Relevance 0.56
With ATRA treatment, a down-regulation of collagen genes was observed.
Negative_regulation (regulation) of collagen
18) Confidence 0.03 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.73 Pain Relevance 0
Furthermore, there was a dose-dependent decrease in soluble extracellular collagen protein in ATRA-treated leiomyoma cells.
Negative_regulation (decrease) of collagen associated with uterine fibroids
19) Confidence 0.03 Published 2008 Journal Clinical Endocrinology Section Abstract Doc Link PMC2610401 Disease Relevance 1.31 Pain Relevance 0
The addition of a glucocorticoid resulted in a transient decrease in collagen deposition.
Negative_regulation (decrease) of collagen
20) Confidence 0.03 Published 2010 Journal European Journal of Haematology Section Abstract Doc Link PMC2970902 Disease Relevance 0.47 Pain Relevance 0

General Comments

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