INT64777

Context Info Confidence 0.38 First Reported 1995 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 32 Total Number 32 Disease Relevance 17.40 Pain Relevance 2.28

extracellular region (COL5A2) molecular_function (COL5A2)

Anatomy Link Frequency smooth muscle cells 2 bar 1 cartilage 1 tendon 1 stellate cells 1 COL5A2 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 120 99.62 Osteoarthritis 194 99.10 tolerance 7 98.86 Inflammation 178 95.82 cytokine 95 95.64 Angina 1 93.24 COX-2 inhibitor 15 92.72 Neuritis 1 82.40 cINOD 11 78.76 imagery 10 77.20

Disease Link Frequency Relevance Heat Metastasis 113 99.64 Endometriosis (extended) 18 99.56 Frailty 93 99.48 Wrinkles 13 99.30 Osteoarthritis 116 99.10 Uterine Fibroids 240 99.00 Blister 1 98.80 Intervertebral Disk Degeneration 39 98.72 Rupture 79 98.56 Aging 37 98.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Predisposing mechanical or ischemic factors could modify tendon collagen composition, characterized by both increased amounts of types III and V fibrils and diminished synthesis of type I collagen, which leads to abnormal fibrillogenesis and production of less resistant fibers that are more susceptible to rupture.

Negative_regulation (diminished) of collagen in tendon associated with rupture

1) Confidence 0.38 Published 2008 Journal Clinics Section Body Doc Link PMC2664193 Disease Relevance 0.42 Pain Relevance 0

A partial defect in type IV collagen, which is involved in repair of the basement membrane, may have played a role in the etiology of pneumothoraces in this patient.

Negative_regulation (defect) of collagen in basement membrane

2) Confidence 0.38 Published 1995 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 8822001 Disease Relevance 0.36 Pain Relevance 0.09

Control samples showed that type V deposited near the vessels only, while surgically obtained specimens displayed type V collagen surrounding other types of collagen fibers in thicker adventitial layers.

Negative_regulation (displayed) of collagen in vessels

3) Confidence 0.34 Published 2008 Journal Clinics Section Abstract Doc Link PMC2664193 Disease Relevance 0.49 Pain Relevance 0

The collagen fibers are infiltrated, impregnated, stabilized, and so prevented from collapsing.

Negative_regulation (impregnated) of collagen

4) Confidence 0.29 Published 2003 Journal Biomed Eng Online Section Body Doc Link PMC222922 Disease Relevance 0.08 Pain Relevance 0

EDTA-Fe-Na (ethylene diamine tetra acetic) can be used as an additive since it is suitable for the prevention of the denaturation of the collagen during and after demineralization.

Negative_regulation (prevention) of collagen

5) Confidence 0.29 Published 2003 Journal Biomed Eng Online Section Body Doc Link PMC222922 Disease Relevance 0.07 Pain Relevance 0

The collagen fibers are infiltrated, impregnated, stabilized, and so prevented from collapsing.

Negative_regulation (prevented) of collagen

6) Confidence 0.29 Published 2003 Journal Biomed Eng Online Section Body Doc Link PMC222922 Disease Relevance 0.08 Pain Relevance 0

TNF alpha increased collagen contractility in comparison to the un-stimulated collagen embedded hUtSMC cells, which was inhibited by indomethacin, while indomethacin alone significantly inhibited contraction.

Negative_regulation (inhibited) of collagen

7) Confidence 0.16 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2645409 Disease Relevance 0.20 Pain Relevance 0.03

Cell contractility was calculated over time, with the collagen gel contraction assay, utilising human primary uterine smooth muscle cells (hUtSMCs) and immortalised myometrial smooth muscle cells (hTERT-HM): a decrease in collagen gel area equated to an increase in contractility.

Negative_regulation (decrease) of collagen in smooth muscle cells

8) Confidence 0.16 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2645409 Disease Relevance 0.27 Pain Relevance 0.05

A bar chart representation from a separate experiment illustrated a 29.3% (P < 0.05) decrease in collagen gel area after thrombin application alone, at 1 hr 30 mins.

Negative_regulation (decrease) of collagen in bar

9) Confidence 0.16 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0

Collagen denaturation epitopes

Negative_regulation (epitopes) of Collagen

10) Confidence 0.14 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.84 Pain Relevance 0.19

CONCLUSIONS: A massive increase in myofibroblast activity, compatible with the activation of stellate cells, is associated with the deposition of collagen types I and IV in the desmoplastic reaction around pancreatic adenocarcinomas.

Negative_regulation (deposition) of collagen in stellate cells

11) Confidence 0.11 Published 2002 Journal Surgery Section Body Doc Link 11854689 Disease Relevance 0.05 Pain Relevance 0

The main frequent changes observed among women aged between 30 and 60 years due to the natural and continuing aging process are the appearance of small wrinkles, atrophy of subcutaneous fat, and decreases in collagen and elastin production.

Negative_regulation (decreases) of collagen in fat associated with aging, wrinkles and frailty

12) Confidence 0.06 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946856 Disease Relevance 0.63 Pain Relevance 0.08

However, how defects in collagen I influence the development of disc degeneration is still unclear and needs further investigation.

Negative_regulation (defects) of collagen associated with intervertebral disk degeneration

13) Confidence 0.06 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.63 Pain Relevance 0

For the experiments, we used the collagen sponge gel with 50 nmol/l of ?

Negative_regulation (used) of collagen

14) Confidence 0.04 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0

L ratio was found, indicating that the net half-life of collagen is slightly decreased after the menopause [16].

Negative_regulation (decreased) of collagen associated with endometriosis (extended)

15) Confidence 0.04 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.61 Pain Relevance 0

Such a decrease in collagen type I half-life is likely to reflect a significant imbalance between anabolic and catabolic processes at the focal area of metastatic invasion [11].

Negative_regulation (decrease) of collagen

16) Confidence 0.04 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.44 Pain Relevance 0

, are involved in the pathogenesis of OA by metalloproteinase (MMP) upregulation and collagen downregulation.

Negative_regulation (downregulation) of collagen associated with metalloproteinase and osteoarthritis

17) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 1.08 Pain Relevance 0.56

With ATRA treatment, a down-regulation of collagen genes was observed.

Negative_regulation (regulation) of collagen

18) Confidence 0.03 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.73 Pain Relevance 0

Furthermore, there was a dose-dependent decrease in soluble extracellular collagen protein in ATRA-treated leiomyoma cells.

Negative_regulation (decrease) of collagen associated with uterine fibroids

19) Confidence 0.03 Published 2008 Journal Clinical Endocrinology Section Abstract Doc Link PMC2610401 Disease Relevance 1.31 Pain Relevance 0

The addition of a glucocorticoid resulted in a transient decrease in collagen deposition.

Negative_regulation (decrease) of collagen

20) Confidence 0.03 Published 2010 Journal European Journal of Haematology Section Abstract Doc Link PMC2970902 Disease Relevance 0.47 Pain Relevance 0

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