INT6478

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Context Info
Confidence 0.58
First Reported 1992
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 36
Total Number 36
Disease Relevance 30.42
Pain Relevance 13.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
monocytes 2
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Etanercept 365 100.00 Very High Very High Very High
Adalimumab 461 99.98 Very High Very High Very High
cytokine 444 99.92 Very High Very High Very High
Arthritis 183 99.82 Very High Very High Very High
antagonist 50 99.76 Very High Very High Very High
corticosteroid 68 99.74 Very High Very High Very High
psoriasis 233 99.04 Very High Very High Very High
Infliximab 321 98.96 Very High Very High Very High
Inflammation 642 98.48 Very High Very High Very High
rheumatoid arthritis 730 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 702 100.00 Very High Very High Very High
Cancer 294 100.00 Very High Very High Very High
Necrosis 75 100.00 Very High Very High Very High
Experimental Arthritis 15 99.82 Very High Very High Very High
Appetite Loss 26 99.76 Very High Very High Very High
Apoptosis 138 99.64 Very High Very High Very High
Stomach Cancer 13 99.58 Very High Very High Very High
Bone Cancer 8 99.10 Very High Very High Very High
Targeted Disruption 50 99.08 Very High Very High Very High
Psoriasis 258 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, adalimumab blocks its interaction with the p55 and p75 cell surface TNF receptors.
Negative_regulation (blocks) of TNF Binding (interaction) of associated with adalimumab
1) Confidence 0.58 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504074 Disease Relevance 0.90 Pain Relevance 0.48
selectively, and blocks the interaction of TNF-?
Negative_regulation (blocks) of TNF Binding (interaction) of
2) Confidence 0.57 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2824092 Disease Relevance 0.90 Pain Relevance 0.75
The beads, and bound TNF, were recovered from solution with the aid of a magnetic field.
Negative_regulation (recovered) of TNF Binding (bound) of
3) Confidence 0.43 Published 1992 Journal J. Chromatogr. Section Abstract Doc Link 1484082 Disease Relevance 0.60 Pain Relevance 0.27
Etanercept binds to TNF-alpha and blocks its interaction with cell surface TNF-alpha receptors, thereby reducing the biologic effect of excess TNF-alpha.
Negative_regulation (blocks) of TNF-alpha Binding (interaction) of associated with etanercept
4) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2211476 Disease Relevance 0.84 Pain Relevance 0.44
Etanercept binds to TNF-alpha and blocks its interaction with cell surface TNF-alpha receptors, thereby reducing the biologic effect of excess TNF-alpha.
Negative_regulation (reducing) of TNF-alpha Binding (interaction) of associated with etanercept
5) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2211476 Disease Relevance 0.84 Pain Relevance 0.44
In light of its inhibitory activity against TNF-?
Negative_regulation (inhibitory) of TNF Binding (activity) of
6) Confidence 0.42 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643111 Disease Relevance 1.55 Pain Relevance 0.29
Soluble TNF receptors prevent TNF from binding to its cellular receptors and hence serve as anti-TNF mechanisms.
Negative_regulation (prevent) of TNF Binding (binding) of
7) Confidence 0.42 Published 1992 Journal Kidney Int. Suppl. Section Abstract Doc Link 1328757 Disease Relevance 0.84 Pain Relevance 0.37
Whereas preincubation of monocytes in RA sera was found to induce the inhibitory effect, preincubation with healthy sera was not sufficient to influence TNF-?
Neg (not) Negative_regulation (sufficient) of TNF Binding (influence) of in monocytes associated with rheumatoid arthritis
8) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.95 Pain Relevance 0.34
inhibitors commercially available: etanercept (Enbrel, Immunex Corporation, Thousand Oaks, CA), a fusion protein dimer of the human TNF-?
Negative_regulation (inhibitors) of TNF Binding (dimer) of associated with etanercept
9) Confidence 0.42 Published 2006 Journal Journal of Burns and Wounds Section Body Doc Link PMC1687150 Disease Relevance 1.79 Pain Relevance 0.73
levels, inhibiting the generation of soluble TNF-?
Negative_regulation (inhibiting) of TNF Binding (generation) of
10) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.47 Pain Relevance 0.29
Patients in the BSRBR receiving treatments which inhibit the action of TNF?
Negative_regulation (inhibit) of TNF Neg (inhibit) Binding (action) of
11) Confidence 0.41 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0.84 Pain Relevance 0.25
g LPS resulted in 100% fetoplacental resorption on day 7 of gestation [19], and the resorption induced by LPS was significantly reduced by pretreatment with a TNF-?
Negative_regulation (reduced) of TNF Binding (pretreatment) of
12) Confidence 0.41 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958556 Disease Relevance 0.79 Pain Relevance 0.05
The molecular mechanism of these TNF blockers, although quite different, involves inhibition of the binding of TNF to cell surface TNF receptors, thereby blocking signal transduction pathways induced or regulated by TNF.
Negative_regulation (inhibition) of TNF Binding (binding) of
13) Confidence 0.41 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 0.83 Pain Relevance 0.67
Etanercept is a recombinant human TNF-receptor fusion protein which inhibits the interaction of endogenous TNF with cell-surface receptors.
Negative_regulation (inhibits) of TNF Binding (interaction) of associated with etanercept
14) Confidence 0.39 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012556 Disease Relevance 0.93 Pain Relevance 0.32
Non-selective biologic inhibitors include, but are not limited to, infliximab, etanercept, and adalimumab, all of which bind to soluble and tmTNF and prevent binding to TNF receptors (Figure 1).
Negative_regulation (prevent) of TNF Binding (binding) of associated with infliximab, adalimumab and etanercept
15) Confidence 0.38 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.43 Pain Relevance 0.63
Immunomodulatory drugs with TNF inhibitory action
Negative_regulation (inhibitory) of TNF Binding (drugs) of
16) Confidence 0.38 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.24 Pain Relevance 0.11
and blocks the interaction of TNF-?
Negative_regulation (blocks) of TNF Binding (interaction) of
17) Confidence 0.30 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 1.23 Pain Relevance 0.92
inhibitor: 115 patients (24.9%) had been treated with two TNF-?
Negative_regulation (inhibitor) of TNF Binding (treated) of
18) Confidence 0.30 Published 2010 Journal Core evidence Section Body Doc Link PMC2899784 Disease Relevance 0.35 Pain Relevance 0.37
The mechanism of action of adalimumab is primarily linked to the neutralization of TNF-alpha bioactivity by preventing the interaction of TNF-alpha with the cell surface TNF receptors.
Negative_regulation (preventing) of TNF Binding (interaction) of associated with adalimumab
19) Confidence 0.28 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721299 Disease Relevance 0.54 Pain Relevance 0.74
, thereby preventing the interaction of TNF-?
Negative_regulation (preventing) of TNF Binding (interaction) of
20) Confidence 0.27 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 1.05 Pain Relevance 0.68

General Comments

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