INT64791

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.17
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Sell) plasma membrane (Sell)
Anatomy Link Frequency
neutrophils 2
blood 1
CD14 1
chest 1
platelet 1
Sell (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 18 100.00 Very High Very High Very High
Inflammation 26 99.36 Very High Very High Very High
cINOD 12 98.20 Very High Very High Very High
Kinase C 1 92.88 High High
rheumatoid arthritis 89 90.40 High High
Morphine 4 80.88 Quite High
Inflammatory response 1 72.84 Quite High
ischemia 4 65.64 Quite High
Pain 2 60.32 Quite High
cytokine 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Angina 9 100.00 Very High Very High Very High
Cv General 3 Under Development 9 99.46 Very High Very High Very High
INFLAMMATION 32 99.36 Very High Very High Very High
Adhesions 30 94.20 High High
Cardiovascular Disease 21 93.28 High High
Rheumatoid Arthritis 101 90.40 High High
Stress 2 83.40 Quite High
Atherosclerosis 29 82.32 Quite High
Emergencies 1 76.60 Quite High
Myocardial Infarction 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies revealed that binding of purified platelet membranes to control neutrophils caused a dose-dependent increase in CD11b surface expression, a decrease in surface L-selectin, and the release of superoxide anions.
Negative_regulation (decrease) of L-selectin in platelet
1) Confidence 0.57 Published 1996 Journal Circulation Section Body Doc Link 8822975 Disease Relevance 0.05 Pain Relevance 0
Systemic neutrophil activation was found in patients with unstable angina compared with those with stable angina assessed by cell surface CD11b expression and shedding of L-selectin (115.6 +/- 10.3 versus 74.0 +/- 6.3 anti-CD11b mean fluorescence intensity, P = .002; 49.8 +/- 6.0 versus 72.1 +/- 4.0 anti-L-selectin mean fluorescence intensity, P = .006).
Negative_regulation (shedding) of L-selectin in neutrophil
2) Confidence 0.42 Published 1996 Journal Circulation Section Body Doc Link 8822975 Disease Relevance 0.07 Pain Relevance 0
However, the KD-IX-73-4, an inhibitor of L-selectin proteolysis was able to block the effect of NSAIDs on L-selectin expression.
Negative_regulation (inhibitor) of L-selectin associated with cinod
3) Confidence 0.35 Published 2000 Journal Blood Section Abstract Doc Link 11071659 Disease Relevance 0.29 Pain Relevance 0.85
RESULTS: PTCA induced a marked up-regulation of CD18, CD11b, CD14 and GPIIb/IIIa with L-selectin shedding and reduced SO formation, whereas only minor L-selectin down-regulation and decreased SO production indicated activation in UA.
Negative_regulation (regulation) of L-selectin in CD14
4) Confidence 0.13 Published 2005 Journal Int. J. Cardiol. Section Body Doc Link 15771923 Disease Relevance 0.14 Pain Relevance 0
In group 1A, the L-selectin decreased significantly at second blood samplings (2.3 +/- 1.2 mg/L, p <0.001 vs baseline), whereas in group 1B there was no significant change in L-selectin (3.9 +/- 1.0 mg/L, p = NS vs baseline).
Negative_regulation (decreased) of L-selectin in blood
5) Confidence 0.09 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9416930 Disease Relevance 0.22 Pain Relevance 0.27
In patients with angina pectoris, plasma levels of soluble L-selectin estimated during chest pain were significantly higher than in the control group and decreased in the absence of chest pain.
Negative_regulation (decreased) of L-selectin in chest associated with angina
6) Confidence 0.06 Published 1998 Journal Heart Vessels Section Abstract Doc Link 10442400 Disease Relevance 1.78 Pain Relevance 1.11
Furthermore, piroxicam significantly decreased the amount of L-selectin shed by cytokine-treated neutrophils, whereas it did not exert this effect on PMA- or A23187-treated neutrophils.
Negative_regulation (decreased) of L-selectin in neutrophils
7) Confidence 0.04 Published 1997 Journal Arthritis Rheum. Section Body Doc Link 9008610 Disease Relevance 0.06 Pain Relevance 0
L-selectin has been shown to be downregulated during chronic inflammation.
Negative_regulation (downregulated) of L-selectin associated with inflammation
8) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945061 Disease Relevance 1.57 Pain Relevance 0.49

General Comments

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