INT64792

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 39
Total Number 49
Disease Relevance 23.21
Pain Relevance 6.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAM) plasma membrane (ITGAM)
Anatomy Link Frequency
neutrophils 31
monocytes 16
granulocytes 8
macrophages 6
leukocyte 6
ITGAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 188 99.20 Very High Very High Very High
Nicotine 126 95.12 Very High Very High Very High
Inflammation 737 94.72 High High
Angina 26 90.00 High High
lidocaine 7 89.60 High High
analgesia 40 88.16 High High
cytokine 206 87.52 High High
Opioid 134 85.60 High High
Potency 4 85.04 High High
cINOD 11 80.40 Quite High
Disease Link Frequency Relevance Heat
Adhesions 715 100.00 Very High Very High Very High
Apoptosis 75 99.36 Very High Very High Very High
INFLAMMATION 976 98.84 Very High Very High Very High
Pulmonary Disease 129 98.40 Very High Very High Very High
Nicotine Addiction 850 98.34 Very High Very High Very High
Reperfusion Injury 71 98.04 Very High Very High Very High
Injury 131 97.84 Very High Very High Very High
Cv Unclassified Under Development 116 97.72 Very High Very High Very High
Occupational Lung Diseases 30 97.32 Very High Very High Very High
Hypersensitivity 12 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, ropivacaine showed no effect on the fMLP-induced CD11b expression in the presence of butan-1-ol, a blocker of phospholipase D (PLD) pathway, which completely inhibited the fMLP-induced CD11b expression in neutrophils.
Positive_regulation (induced) of Gene_expression (expression) of CD11b in neutrophils
1) Confidence 0.69 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.37 Pain Relevance 0.24
In vitro studies revealed that binding of purified platelet membranes to control neutrophils caused a dose-dependent increase in CD11b surface expression, a decrease in surface L-selectin, and the release of superoxide anions.
Positive_regulation (increase) of Gene_expression (expression) of CD11b in platelet
2) Confidence 0.67 Published 1996 Journal Circulation Section Body Doc Link 8822975 Disease Relevance 0.05 Pain Relevance 0
NF-kappaB activation, CD11b/CD18 expression, and the production of TNF-alpha, IL-8, and IL-6 in monocytes and granulocytes were inhibited by NCR in vitro.
Positive_regulation (activation) of Gene_expression (expression) of CD11b in granulocytes
3) Confidence 0.67 Published 2005 Journal Shock Section Abstract Doc Link 16044078 Disease Relevance 0.37 Pain Relevance 0.36
However, ropivacaine showed no effect on the fMLP-induced CD11b expression in the presence of butan-1-ol, a blocker of phospholipase D (PLD) pathway, which completely inhibited the fMLP-induced CD11b expression in neutrophils.
Neg (no) Positive_regulation (induced) of Gene_expression (expression) of CD11b in neutrophils
4) Confidence 0.50 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.36 Pain Relevance 0.19
In addition, ropivacaine more potently inhibited the fMLP-induced CD11b expression in the presence of ethylene glycol-bis(2-aminoethylether)-N,N,N ,N -tetraacetic acid (EGTA), a chelator of extracellular Ca(2+).
Positive_regulation (induced) of Gene_expression (expression) of CD11b
5) Confidence 0.50 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.43 Pain Relevance 0.34
METHODS: Isolated human neutrophil CD11b and CD18, and human umbilical vein endothelial cell (HUVEC) ICAM-1 expression and supernatant IL-1beta concentrations in response to hypoxia-reoxygenation were studied in the presence or absence of different concentrations of lidocaine (0.005, 0.05 and 0.5 mg mL(-1)).
Positive_regulation (response) of Gene_expression (expression) of CD11b in neutrophil
6) Confidence 0.49 Published 2004 Journal Eur J Anaesthesiol Section Body Doc Link 15719860 Disease Relevance 0.29 Pain Relevance 0
We found that coronary angioplasty with stent implantation produces an increase in the cell surface expression of CD11b/CD18 in neutrophils and CD38 in monocytes, following a similar time-course with a peak after 24 h, returning to basal levels after 48 h and a second peak after 7 days.
Positive_regulation (increase) of Gene_expression (expression) of CD11b in neutrophils
7) Confidence 0.49 Published 2004 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15080559 Disease Relevance 0.30 Pain Relevance 0.26
The peak plasma levels of IL-8 (172.24 +/- 37.82 pg/mL at 12 hours) and vWF (256 +/- 42.32% at 4 hours) significantly increased after coronary angioplasty (both p < 0.01), and were associated with significant time course increases in surface expression of CD11b/CD18 (p < 0.01) and CD41 (p < 0.01).
Positive_regulation (increases) of Gene_expression (expression) of CD11b in plasma
8) Confidence 0.49 Published 2002 Journal Jpn Heart J Section Abstract Doc Link 12025897 Disease Relevance 0.98 Pain Relevance 0.95
Ropivacaine exerted a time-dependent effect on CD11b expression only (24% +/- 34%; P < .05).
Positive_regulation (exerted) of Gene_expression (expression) of CD11b
9) Confidence 0.46 Published 2008 Journal Reg Anesth Pain Med Section Body Doc Link 18675739 Disease Relevance 0 Pain Relevance 0
RESULTS: Indomethacin caused a concentration- and time-dependent upregulation of CD11b and CD18 expression and PMN adhesion to endothelial cells.
Positive_regulation (upregulation) of Gene_expression (expression) of CD11b in PMN
10) Confidence 0.42 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
Results from the present study demonstrate an increased expression of the adhesion molecule CD11b by both neutrophils and monocytes following tourniquet-applied upper limb orthopaedic surgery.
Positive_regulation (increased) of Gene_expression (expression) of CD11b in upper limb associated with adhesions
11) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.82 Pain Relevance 0.08
Results demonstrate that neutrophil CD11b expression increased from baseline (29.11±5.61), during 5 minutes (30.71±6.54) and 15 minutes (33.95±6.44) reperfusion, whilst monocyte CD11b expression increased from baseline (41.61±4.61), during 5 minutes (45.46±6.23) and 15 minutes (47.97±6.60) reperfusion.
Positive_regulation (increased) of Gene_expression (expression) of CD11b in monocyte
12) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0 Pain Relevance 0
Results demonstrate that neutrophil CD11b expression increased from baseline (29.11±5.61), during 5 minutes (30.71±6.54) and 15 minutes (33.95±6.44) reperfusion, whilst monocyte CD11b expression increased from baseline (41.61±4.61), during 5 minutes (45.46±6.23) and 15 minutes (47.97±6.60) reperfusion.
Positive_regulation (increased) of Gene_expression (expression) of CD11b in neutrophil
13) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0 Pain Relevance 0
Thus increased expression of CD11b and decreased expression of CD62L by neutrophils and monocytes may play a central role as the mechanism by which leukocyte adhesion and consequently activation occurs following surgery [2], [21], [26].
Positive_regulation (increased) of Gene_expression (expression) of CD11b in monocytes associated with adhesions
14) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.80 Pain Relevance 0.08
RESULTS: Indomethacin caused a concentration- and time-dependent upregulation of CD11b and CD18 expression and PMN adhesion to endothelial cells.
Positive_regulation (upregulation) of Gene_expression (expression) of CD11b in PMN
15) Confidence 0.30 Published 1997 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9218092 Disease Relevance 0 Pain Relevance 0
Our results are in line with those of Sutter et al [26] who found increased cell surface expression of CD11b and CD18 by granulocytes and monocytes after tourniquet ischaemia during elective hand surgery.
Positive_regulation (increased) of Gene_expression (expression) of CD11b in granulocytes associated with cv unclassified under development
16) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.64 Pain Relevance 0.07
Results demonstrate that neutrophil CD11b expression increased from baseline (29.11±5.61), during 5 minutes (30.71±6.54) and 15 minutes (33.95±6.44) reperfusion, whilst monocyte CD11b expression increased from baseline (41.61±4.61), during 5 minutes (45.46±6.23) and 15 minutes (47.97±6.60) reperfusion.
Positive_regulation (increased) of in monocyte Gene_expression (expression) of CD11b in neutrophil
17) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0 Pain Relevance 0
Measurement of cell surface expression of CD62L and CD11b
Positive_regulation (Measurement) of Gene_expression (expression) of CD11b
18) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.06 Pain Relevance 0.06
Thus increased expression of CD11b and decreased expression of CD62L by neutrophils and monocytes may play a central role as the mechanism by which leukocyte adhesion and consequently activation occurs following surgery [2], [21], [26].
Positive_regulation (increased) of Gene_expression (expression) of CD11b in monocytes associated with adhesions
19) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.80 Pain Relevance 0.08
RESULTS: I/R plasma (withdrawn 15 min following tourniquet release) increased isolated neutrophil CD11b (P = 0.03), CD18 (P = 0.01) and endothelial intercellular adhesion molecule-1 (ICAM-1) (P = 0.008) expression compared to baseline.
Positive_regulation (increased) of Gene_expression (expression) of CD11b in neutrophil
20) Confidence 0.25 Published 2004 Journal Eur J Anaesthesiol Section Body Doc Link 15717706 Disease Relevance 0.06 Pain Relevance 0

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