INT64797

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.24
First Reported 1996
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 18
Total Number 23
Disease Relevance 9.71
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ALPP)
Anatomy Link Frequency
osteoblasts 4
chondrocyte 1
stromal cells 1
urine 1
ALPP (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 24 99.64 Very High Very High Very High
pulpitis 7 99.52 Very High Very High Very High
Osteoarthritis 175 93.48 High High
Potency 3 91.84 High High
Paracetamol 28 89.68 High High
Spinal cord 6 82.88 Quite High
Neuritis 1 71.56 Quite High
Multiple sclerosis 1 68.68 Quite High
Inflammatory response 3 65.52 Quite High
antagonist 2 61.44 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 266 100.00 Very High Very High Very High
Pulpitis 7 99.52 Very High Very High Very High
Testicular Cancer 4 99.08 Very High Very High Very High
Chronic Renal Failure 14 97.84 Very High Very High Very High
Papillomavirus Infection 123 96.94 Very High Very High Very High
Ovarian Cancer 10 96.56 Very High Very High Very High
Pyelonephritis 4 94.48 High High
Osteoarthritis 175 93.48 High High
Renal Disease 7 93.40 High High
Hepatotoxicity 7 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of melatonin on ALP activity: As a marker for ADSC differentiation into osteoblasts, ALP levels were measured after 14 and 28 days.
Regulation (measured) of ALP in osteoblasts
1) Confidence 0.24 Published 2008 Journal Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India Section Body Doc Link PMC2739564 Disease Relevance 0.12 Pain Relevance 0
Enzymatic ALP control values for the normal healthy pulps were 110.96+/-20.93.
Regulation (values) of ALP
2) Confidence 0.24 Published 2001 Journal J Endod Section Abstract Doc Link 11487147 Disease Relevance 0.58 Pain Relevance 0.58
The hPLAP/PLAP-like enzyme activity cutoff value—defined as the
Regulation (value) of hPLAP
3) Confidence 0.23 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.15 Pain Relevance 0
The tissue samples in enzymatic investigations illustrated that the results in Table 4 were related to the intravenous injection of the powders and the enzymatic activation exhibited no change in the quantity of ALP and AST with the reduced and normal size of the injected drug.
Neg (no) Regulation (change) of ALP
4) Confidence 0.21 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2865014 Disease Relevance 0.49 Pain Relevance 0.24
However, no significant change of the serum AST, ALP, creatinine and urea was observed in those rats after being administered with 14 days of fresh star fruit juice at different storage times as compared to the control rats [Table 2].
Neg (no) Regulation (change) of ALP
5) Confidence 0.21 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900059 Disease Relevance 0.38 Pain Relevance 0
Fig. 4 shows longitudinal changes in the serum levels of calcium, phosphorus, ALP, and iPTH.
Regulation (changes) of ALP
6) Confidence 0.16 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2703758 Disease Relevance 0.13 Pain Relevance 0
We first examined the effect of CS and GS on alkaline phosphatase and osteocalcin in order to evaluate whether these agents could alter the level of bone markers of terminally differentiated osteoblasts.
Spec (examined) Regulation (effect) of alkaline phosphatase in osteoblasts
7) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.68 Pain Relevance 0.27
Neither alkaline phosphatase nor osteocalcin was truly affected by CS or GS alone or together; this is true for both basal conditions and hormonal stimulation.
Neg (Neither) Regulation (affected) of alkaline phosphatase
8) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.72 Pain Relevance 0.26
The effect of these drugs or of the addition of LTB(4) on alkaline phosphatase (AP) activity and osteocalcin release by OA and normal osteoblasts was determined.
Regulation (effect) of alkaline phosphatase in osteoblasts
9) Confidence 0.10 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0.09 Pain Relevance 0
values of PLAP and PLAP-like enzyme activity or serum
Regulation (values) of PLAP
10) Confidence 0.07 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 1.21 Pain Relevance 0
There were significant differences in changes in urinary NTX and CTX levels and serum bone-specific ALP levels, but not in those in serum NTX levels, between the 2 groups (two-way ANOVA with repeated measurements, Table 2).
Regulation (changes) of ALP
11) Confidence 0.07 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2703758 Disease Relevance 0.15 Pain Relevance 0
There were no significant differences in changes in serum calcium, phosphorus, ALP, and iPTH levels between the 2 groups (two-way ANOVA with repeated measurements, Table 2).
Regulation (changes) of ALP
12) Confidence 0.07 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2703758 Disease Relevance 0.16 Pain Relevance 0
Mean values of serum P and Ca, Ca × P, iPTH, ALP, mean dialytic age and mean duration of pre-dialysis CKD duration are presented in Table 1.


Regulation (values) of ALP associated with chronic renal failure
13) Confidence 0.06 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2644631 Disease Relevance 0.93 Pain Relevance 0
The maximal stimulatory effect on ALP was observed after 48 hours of treatment with 50 mM quercetin.
Regulation (effect) of ALP
14) Confidence 0.06 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2685048 Disease Relevance 0.07 Pain Relevance 0.06
However, there was a significant change in mean levels of iPTH ± SD (1196 ± 381 pg/ml versus 256 ± 160 pg/ml; P < 0.0001) and mean serum ALP ± SD values (428 ± 294 versus 223 ± 88 IU/l; P = 0.04).
Regulation (values) of ALP
15) Confidence 0.05 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2644631 Disease Relevance 0.47 Pain Relevance 0.16
Changes in serum or urine levels of bALP, PINP, DKK-1, NTX-I, PTH and calcium were analyzed by comparison of the value of each marker at a given time point with the same marker pre-treatment using a Wilcoxon signed rank test.
Regulation (Changes) of bALP in urine
16) Confidence 0.01 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0 Pain Relevance 0
We also employed an N-terminal lipocortin-1 peptide spanning aa 1-26, a proteolytic fragment of lipocortin-1 where the respective N-terminal region was clipped off, tested blocking with a neutralizing antibody, and investigated the effect of alkaline phosphatase treatment.
Spec (investigated) Regulation (effect) of alkaline phosphatase
17) Confidence 0.01 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8823388 Disease Relevance 0.36 Pain Relevance 0.11
In patients who did not respond to treatment with a partial response or better, no significant changes in bALP or PINP were observed (Fig. 1C,D).
Regulation (changes) of bALP
18) Confidence 0.01 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.15 Pain Relevance 0.13
Unlike bALP which was relatively unaffected by the addition of the glucocorticoid, PINP showed a profound but transient decline each time dexamethasone was given to the patient.
Regulation (unaffected) of bALP associated with dexamethasone
19) Confidence 0.01 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.45 Pain Relevance 0.10
Glucocorticoids, such as dexamethasone, are potent inducers in human and rat stromal cells, but they have no effect on alkaline phosphatase activity in mouse stromal cells.[2829] On the contrary, bone morphogenetic proteins (BMPs) are potent inducers of osteogenesis in both mouse and rat bone marrow stromal cells,[30] but Diefenderfer et al. have shown that BMP-2 alone is a poor osteoblast inducer in human marrow-derived stromal cells.[31]
Neg (no) Regulation (effect) of alkaline phosphatase in stromal cells associated with osteoporosis and dexamethasone
20) Confidence 0.01 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.39 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox