INT6480

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2010
Negated 5
Speculated 3
Reported most in Body
Documents 59
Total Number 62
Disease Relevance 33.70
Pain Relevance 16.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN) extracellular region (IL1RN) plasma membrane (IL1RN)
nucleus (IL1RN) intracellular (IL1RN) cytoplasm (IL1RN)
Anatomy Link Frequency
plasma 5
tears 3
synovial fluid 2
chondrocyte 2
T84 2
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 965 100.00 Very High Very High Very High
antagonist 190 100.00 Very High Very High Very High
Inflammatory mediators 23 100.00 Very High Very High Very High
spinal inflammation 13 100.00 Very High Very High Very High
anakinra 23 99.92 Very High Very High Very High
Pain score 4 99.76 Very High Very High Very High
Inflammation 700 99.48 Very High Very High Very High
Pain 64 98.76 Very High Very High Very High
dexamethasone 3 98.26 Very High Very High Very High
Spinal cord 1 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 778 100.00 Very High Very High Very High
Low Back Pain 71 100.00 Very High Very High Very High
Eye Disease 260 99.84 Very High Very High Very High
Adenocarcinoma 186 99.82 Very High Very High Very High
Pain 71 99.76 Very High Very High Very High
Myocardial Infarction 22 99.74 Very High Very High Very High
Sepsis 15 99.60 Very High Very High Very High
Disorders Of Creatine Metabolism 5 99.58 Very High Very High Very High
Disease 325 99.48 Very High Very High Very High
Osteoarthritis 518 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, contrasting findings were obtained for the association of IL-1RN*2 with IL-1ra levels; some authors found that the IL-1RN*2 allele is associated with reduced IL-1ra [14,57,58], but other authors observed no association [29] or even increased IL-1ra [16,18,21].
Neg (no) Positive_regulation (increased) of IL-1ra
1) Confidence 0.69 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.36 Pain Relevance 0.08
RESULTS: OA samples spontaneously produced higher levels of IL-1Ra than normal samples (130+/-2.3 vs 30+/-3.1 pg/mI).
Positive_regulation (levels) of IL-1Ra
2) Confidence 0.65 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11764219 Disease Relevance 0.07 Pain Relevance 0
In contrast to piroxicam and aspirin, aceclofenac 10 microg/ml and TNF-alpha 10 ng/ml increased almost 46 times the basal amount of IL-1Ra produced by OA chondrocytes.
Positive_regulation (increased) of IL-1Ra in chondrocytes
3) Confidence 0.65 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11764219 Disease Relevance 0.05 Pain Relevance 0
Although levels of IL-1Ra and sTNFR are elevated in patients on HD, these levels reflect the host response to inflammation.
Positive_regulation (elevated) of IL-1Ra associated with inflammation
4) Confidence 0.49 Published 1992 Journal Kidney Int. Suppl. Section Abstract Doc Link 1328757 Disease Relevance 0.44 Pain Relevance 0.25
Summing up, in vivo, in humans, in the dose range tested, VRCTC-310-Onco induces IL-1ra, and does not consistently modify IL-1alpha or TNF-alpha serum levels.
Positive_regulation (induces) of IL-1ra
5) Confidence 0.47 Published 2001 Journal Immunol. Lett. Section Abstract Doc Link 11137138 Disease Relevance 0.31 Pain Relevance 0.32
The addition of dexamethasone (required to reduce pain with the highest doses) inhibited IL-1alpha and enhanced the induction of IL-1ra by VRCTC-310-Onco.
Positive_regulation (induction) of IL-1ra associated with pain and dexamethasone
6) Confidence 0.47 Published 2001 Journal Immunol. Lett. Section Abstract Doc Link 11137138 Disease Relevance 0.33 Pain Relevance 0.34
The induction of a systemic cytokine response, including elevated plasma levels of interleukin (IL)-1 receptor antagonist (IL-1ra), IL-6, IL-8, IL-10, and granulocyte colony-stimulating factor (G-CSF), following intense physical activity, is well documented [1-5].
Positive_regulation (induction) of IL-1ra in granulocyte associated with antagonist and cytokine
7) Confidence 0.46 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.49 Pain Relevance 0.28
Specifically, plasma levels of the IL-1 receptor antagonist (IL-1ra) increase dramatically after intense exercise, and accumulating evidence points to an effect of genetic polymorphisms on athletic phenotypes.
Positive_regulation (increase) of IL-1ra in plasma associated with antagonist
8) Confidence 0.46 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC2837019 Disease Relevance 0.09 Pain Relevance 0.23
Specifically, plasma levels of the IL-1 receptor antagonist (IL-1ra) increase dramatically after intense exercise, and accumulating evidence points to an effect of genetic polymorphisms on athletic phenotypes.
Positive_regulation (increase) of IL-1 receptor antagonist in plasma associated with antagonist
9) Confidence 0.46 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC2837019 Disease Relevance 0.10 Pain Relevance 0.23
and IL-1ra increase, and thus, plasma levels of these cytokines are positively correlated [17].
Positive_regulation (increase) of IL-1ra in plasma associated with cytokine
10) Confidence 0.46 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.57 Pain Relevance 0.40
These show IL-1Ra quickly extinguishes MDP expression but, in the absence of IL-1Ra, IL-1-driven MDP expression is maintained even in prolonged tissue culture outside the disease context of the spine.
Positive_regulation (absence) of IL-1Ra in spine associated with disease
11) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.28 Pain Relevance 0.22
These show IL-1Ra quickly extinguishes MDP expression but, in the absence of IL-1Ra, IL-1-driven MDP expression is maintained even in prolonged tissue culture outside the disease context of the spine.
Positive_regulation (extinguishes) of IL-1Ra in spine associated with disease
12) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.28 Pain Relevance 0.22
Basal IL-1ra was 794 +/- 97 pg/ml, by 3 h it was similar, 651 +/- 99 pg/ml and at 24 h p.i. it increased to 1197 +/- 122 pg/ml (P<0.001).
Positive_regulation (increased) of IL-1ra
13) Confidence 0.43 Published 2001 Journal Immunol. Lett. Section Abstract Doc Link 11137138 Disease Relevance 0.36 Pain Relevance 0.35
Pre-clinical studies indicate that IL-1 may be a primary driver of ACS and that the naturally occurring interleukin-1 receptor antagonist (IL-1ra) may inhibit the atherosclerotic process.
Positive_regulation (occurring) of IL-1ra associated with atherosclerosis and antagonist
14) Confidence 0.42 Published 2008 Journal Trials Section Abstract Doc Link PMC2289802 Disease Relevance 0.86 Pain Relevance 0.34
are upregulated without increased IL-1Ra.
Neg (without) Positive_regulation (increased) of IL-1Ra
15) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.13 Pain Relevance 0.07
increased and IL-1Ra decreased enzyme expression in a similar pattern to that in moderately degenerate IVDs.


Positive_regulation (increased) of IL-1Ra
16) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.03
are upregulated without increased IL-1Ra.
Positive_regulation (upregulated) of IL-1Ra
17) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.13 Pain Relevance 0.07
Cessation of IL1RA resulted in rapid improvement of liver enzymes, but two patients experienced a sJIA flare, requiring pulse corticosteroid therapy.
Positive_regulation (Cessation) of IL1RA in liver associated with corticosteroid
18) Confidence 0.41 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2805658 Disease Relevance 1.25 Pain Relevance 0.29
Prognostic role of interleukin-1beta gene and interleukin-1 receptor antagonist gene polymorphisms in patients with advanced gastric cancer.
Positive_regulation (role) of interleukin-1 receptor antagonist associated with antagonist and stomach cancer
19) Confidence 0.38 Published 2005 Journal J. Clin. Oncol. Section Title Doc Link 15800325 Disease Relevance 0.46 Pain Relevance 0.21
Pre-clinical studies indicate that IL-1 may be a primary driver of ACS and that the naturally occurring interleukin-1 receptor antagonist (IL-1ra) may inhibit the atherosclerotic process.
Positive_regulation (occurring) of antagonist associated with atherosclerosis and antagonist
20) Confidence 0.37 Published 2008 Journal Trials Section Abstract Doc Link PMC2289802 Disease Relevance 0.86 Pain Relevance 0.34

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