INT64807

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 1.21
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
MCF-7 2
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 13 100.00 Very High Very High Very High
Opioid 94 99.80 Very High Very High Very High
Enkephalin 40 97.88 Very High Very High Very High
action potential duration 2 96.20 Very High Very High Very High
Cannabinoid 8 86.32 High High
dorsal root ganglion 7 83.64 Quite High
antagonist 34 70.08 Quite High
Hyperalgesia 21 62.60 Quite High
tolerance 15 62.28 Quite High
Analgesic 18 61.88 Quite High
Disease Link Frequency Relevance Heat
Cancer 20 88.12 High High
Ganglion Cysts 7 83.64 Quite High
Nociception 27 82.40 Quite High
Adenocarcinoma 9 79.04 Quite High
Bordatella Infection 3 69.28 Quite High
Breast Cancer 25 67.68 Quite High
Hyperalgesia 25 62.60 Quite High
Hypertension 4 62.00 Quite High
Muscular Spasm 1 60.16 Quite High
Atherosclerosis 3 59.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Histamine (10 microM) as a positive control caused an increase in Ca2+i, as expected.
Positive_regulation (caused) of Positive_regulation (increase) of Ca2
1) Confidence 0.41 Published 1996 Journal Reg Anesth Section Body Doc Link 8826019 Disease Relevance 0 Pain Relevance 0
Ethanol alone, at doses of 2-5% (v/v) also caused a sustained elevation in Ca2+i of physiologically significant magnitude.
Positive_regulation (caused) of Positive_regulation (elevation) of Ca2
2) Confidence 0.41 Published 1996 Journal Reg Anesth Section Body Doc Link 8826019 Disease Relevance 0 Pain Relevance 0
HPLC fractionation reveals six distinct lipophilic fractions that induce this transient increase in cytosolic Ca2+.
Positive_regulation (induce) of Positive_regulation (increase) of Ca2
3) Confidence 0.29 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.12
For example, [Ca2+]c elevation and phosphorylation of p47phox by different protein kinases (PKC, MAPK, PKA, p21-activated kinase) allowing conformational changes of p47phox may promote oxidase activation in response to GM-CSF [25].
Spec (may) Positive_regulation (promote) of Positive_regulation (elevation) of Ca2
4) Confidence 0.26 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Rho kinases, in turn, phosphorylate, and inactivate, myosin phosphatase, MLC itself and the myosin phosphatase inhibitor CPI-17 resulting in the Ca2+-independent increase in overall levels of phosphorylated MLC through a Rho/Rho kinase-mechanism [2,4,5].
Positive_regulation (resulting) of Neg (independent) Positive_regulation (increase) of Ca2
5) Confidence 0.25 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.29 Pain Relevance 0
However, these probes cannot be selectively targeted to a specific cellular compartment without microinjection, and [Ca2+]c elevation can be generated artifactually as a result of the rapid diffusion of the probe-Ca2+ complex away from a more restricted region of the cytosol.
Positive_regulation (generated) of Positive_regulation (elevation) of Ca2
6) Confidence 0.24 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.04
Strong evidence for Ca2+ dependence of NADPH oxidase activation came from deprivation of extracellular Ca2+ and depletion of intracellular Ca2+ stores [34567].
Positive_regulation (dependence) of Positive_regulation (activation) of Ca2 associated with addiction
7) Confidence 0.24 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.05
In MCF-7 cells, application of the super-cooling agent Icilin, which is ~200-fold more potent than menthol, activated both an outwardly rectifying current and an elevation of cytoplasmic Ca2+ in a small fraction of cells (30% of all the cells tested).
Positive_regulation (activated) of Positive_regulation (elevation) of Ca2 in MCF-7
8) Confidence 0.19 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.49 Pain Relevance 0
Since activation of MOR1K results in the intracellular accumulation of Ca2+ and showed a tendency to increase cAMP levels, we examined whether MOR1K couples to G?
Spec (examined) Positive_regulation (activation) of Positive_regulation (accumulation) of Ca2
9) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0.38 Pain Relevance 0.65
Hence, the complete sequences of CHR and CAT appear to be essential for the induction of the transient Ca2+ influx.
Positive_regulation (essential) of Positive_regulation (induction) of Ca2
10) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0 Pain Relevance 0
Elevation of intracellular Ca2+ is required for opioid peptide release [17].
Positive_regulation (required) of Positive_regulation (Elevation) of Ca2 associated with opioid
11) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.06 Pain Relevance 0.84
This leads to an increase in cytosolic free Ca2+, which in turn leads to activation of Ca2+-dependent catabolic processes, including stimulation of proteases, endonucleases, and phospholipases.
Positive_regulation (leads) of Positive_regulation (increase) of Ca2
12) Confidence 0.06 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0 Pain Relevance 0

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