INT6481

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Context Info
Confidence 0.48
First Reported 1988
Last Reported 2011
Negated 21
Speculated 7
Reported most in Body
Documents 624
Total Number 633
Disease Relevance 510.20
Pain Relevance 214.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophages 13
T cells 12
monocytes 8
endothelial cells 7
joint 6
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9157 100.00 Very High Very High Very High
rheumatoid arthritis 8099 100.00 Very High Very High Very High
cytokine 6367 100.00 Very High Very High Very High
Infliximab 3881 100.00 Very High Very High Very High
Etanercept 3656 100.00 Very High Very High Very High
Adalimumab 3306 100.00 Very High Very High Very High
methotrexate 2380 100.00 Very High Very High Very High
spinal inflammation 1484 100.00 Very High Very High Very High
antagonist 748 100.00 Very High Very High Very High
metalloproteinase 630 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 9905 100.00 Very High Very High Very High
Disease 8941 100.00 Very High Very High Very High
Rheumatoid Arthritis 8357 100.00 Very High Very High Very High
Apoptosis 4109 100.00 Very High Very High Very High
Cancer 4044 100.00 Very High Very High Very High
Infection 3575 100.00 Very High Very High Very High
Low Back Pain 1813 100.00 Very High Very High Very High
Necrosis 1450 100.00 Very High Very High Very High
Diabetes Mellitus 867 100.00 Very High Very High Very High
Pancreatic Cancer 746 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Association and dissociation rates of binding to soluble TNF were measured by surface plasmon resonance, and were found to be similar for adalimumab, infliximab, and etanercept, as were their calculated binding affinities.
TNF Binding (binding) of associated with infliximab, adalimumab and etanercept
1) Confidence 0.48 Published 2009 Journal Clin. Immunol. Section Abstract Doc Link 19188093 Disease Relevance 0.58 Pain Relevance 1.12
The beads, and bound TNF, were recovered from solution with the aid of a magnetic field.
TNF Binding (bound) of
2) Confidence 0.48 Published 1992 Journal J. Chromatogr. Section Abstract Doc Link 1484082 Disease Relevance 0.60 Pain Relevance 0.27
In particular, antibodies that bind to and neutralise TNF have been sought as a means to inhibit TNF activity.
TNF Binding (bind) of
3) Confidence 0.48 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19689289 Disease Relevance 1.45 Pain Relevance 0.63
Adalimumab is the first fully human anti-tumor necrosis factor (TNF-alpha) monoclonal antibody and it binds to both soluble and cell-bound TNF-alpha, modulating biological responses linked to this cytokine.
TNF-alpha Binding (binds) of associated with necrosis, cancer, adalimumab and cytokine
4) Confidence 0.48 Published 2008 Journal Actas Dermosifiliogr Section Abstract Doc Link 18680688 Disease Relevance 0.53 Pain Relevance 0.46
It is a chimeric monoclonal antibody that binds soluble and membrane-bound TNF-?
TNF Binding (binds) of
5) Confidence 0.48 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504074 Disease Relevance 0.66 Pain Relevance 0.47
Upon binding to TNF-?
TNF Binding (binding) of
6) Confidence 0.48 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504074 Disease Relevance 0.89 Pain Relevance 0.50
, adalimumab blocks its interaction with the p55 and p75 cell surface TNF receptors.
TNF Binding (interaction) of associated with adalimumab
7) Confidence 0.48 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504074 Disease Relevance 0.89 Pain Relevance 0.48
These interactions between TNF, GnRH and gonadotrophs are discussed.
TNF Binding (interactions) of in gonadotrophs
8) Confidence 0.48 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 17985235 Disease Relevance 1.08 Pain Relevance 0.38
Etanercept, adalimumab and infliximab have different binding characteristics, with infliximab and adalilumab binding to both soluble and membrane-bound TNF and etanercept binding primarily to soluble TNF (Scallon et al 2002).
TNF Binding (binding) of associated with infliximab, adalimumab and etanercept
9) Confidence 0.48 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643111 Disease Relevance 1.03 Pain Relevance 0.67
Etanercept, adalimumab and infliximab have different binding characteristics, with infliximab and adalilumab binding to both soluble and membrane-bound TNF and etanercept binding primarily to soluble TNF (Scallon et al 2002).
TNF Binding (binding) of associated with infliximab, adalimumab and etanercept
10) Confidence 0.48 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643111 Disease Relevance 1.09 Pain Relevance 0.67
Receptor fusion has a fast dissociation rate: it sheds 50% of sTNF and 90% of tmTNF in only 10 minutes, but can bind TNF again immediately [47].
TNF Binding (bind) of
11) Confidence 0.48 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.38 Pain Relevance 0.26
Variance analysis was used to evaluate the interaction between TNF?
TNF Binding (interaction) of
12) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991021 Disease Relevance 0.32 Pain Relevance 0.38
Etanercept binds to TNF-alpha and blocks its interaction with cell surface TNF-alpha receptors, thereby reducing the biologic effect of excess TNF-alpha.
TNF-alpha Binding (binds) of associated with etanercept
13) Confidence 0.48 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2211476 Disease Relevance 0.84 Pain Relevance 0.41
Soluble TNF receptors prevent TNF from binding to its cellular receptors and hence serve as anti-TNF mechanisms.
TNF Binding (binding) of
14) Confidence 0.47 Published 1992 Journal Kidney Int. Suppl. Section Abstract Doc Link 1328757 Disease Relevance 0.84 Pain Relevance 0.37
Soluble TNF receptors prevent TNF from binding to its cellular receptors and hence serve as anti-TNF mechanisms.
TNF Binding (binding) of
15) Confidence 0.47 Published 1992 Journal Kidney Int. Suppl. Section Abstract Doc Link 1328757 Disease Relevance 0.85 Pain Relevance 0.38
blockade is associated with TNF?
TNF Binding (associated) of
16) Confidence 0.47 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564801 Disease Relevance 0.18 Pain Relevance 0.15
Tumor necrosis factor alpha (TNF) injected into the sciatic nerve and neutralizing antibodies to its receptor injected around the nerve are respectively associated with inducing and blocking pain behavior beginning 1 to 3 days post-injection.
TNF Binding (associated) of in sciatic nerve associated with pain, necrosis, cancer and sciatic nerve
17) Confidence 0.47 Published 2000 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 10905468 Disease Relevance 0.37 Pain Relevance 0.27
Although TNF binds to each with high affinity, TNF RI is more ubiquitously expressed and it is generally believed that TNF RI is responsible for the majority of biological actions of TNF while TNF RII may function to potentate the effects of TNF RI.
TNF Binding (binds) of
18) Confidence 0.47 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206382 Disease Relevance 0 Pain Relevance 0.10
In a group of 299 migraine patients and 306 control subjects, the association of the -308 G/A polymorphism in the tumor necrosis factor-alpha gene (TNFalpha) with the occurrence and clinical characteristics of migraine was tested.
TNFalpha Binding (association) of associated with necrosis, cancer and migraine
19) Confidence 0.47 Published 2004 Journal Neurology Section Abstract Doc Link 14718719 Disease Relevance 0.86 Pain Relevance 0.57
is considered as a proinflammatory cytokine and a causal factor of inflammation because the binding of TNF-?
TNF Binding (binding) of associated with inflammation and cytokine
20) Confidence 0.47 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.94 Pain Relevance 0.29

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