INT64815

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 49
Total Number 49
Disease Relevance 21.47
Pain Relevance 8.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Anatomy Link Frequency
liver 2
brains 2
neuronal 1
hepatocyte 1
striatum 1
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 59 99.66 Very High Very High Very High
Inflammation 656 99.60 Very High Very High Very High
adenocard 20 98.66 Very High Very High Very High
cytokine 549 98.24 Very High Very High Very High
Hippocampus 28 97.56 Very High Very High Very High
Inflammatory response 69 97.28 Very High Very High Very High
Enkephalin 12 96.54 Very High Very High Very High
Eae 4 92.68 High High
anticonvulsant 5 89.20 High High
gABA 16 86.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 717 99.60 Very High Very High Very High
Hepatotoxicity 61 99.26 Very High Very High Very High
Disease 478 99.20 Very High Very High Very High
Apoptosis 248 99.12 Very High Very High Very High
Inflammatory Bowel Disease 6 99.04 Very High Very High Very High
Burns 222 99.00 Very High Very High Very High
Shock 18 98.92 Very High Very High Very High
Neurodegenerative Disease 28 97.96 Very High Very High Very High
Colon Cancer 55 97.80 Very High Very High Very High
Stress 122 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The APAP-induced hepatic AP-1 DNA binding complex had affinity for both the consensus AP-1 and CRE sequences.
AP-1 Binding (complex) of associated with paracetamol
1) Confidence 0.48 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.56 Pain Relevance 0.54
Recent studies support the complexity of the interactions between AP-1 and NF-?
AP-1 Binding (interactions) of
2) Confidence 0.48 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.16 Pain Relevance 0.15
The APAP-induced hepatic AP-1 DNA binding complex had affinity for both the consensus AP-1 and CRE sequences.
AP-1 Binding (affinity) of associated with paracetamol
3) Confidence 0.37 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.57 Pain Relevance 0.54
B pathways and that interactions between the AP-1 and NF-?
AP-1 Binding (interactions) of
4) Confidence 0.37 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.15 Pain Relevance 0.14
In the present studies, we determined that exposure to necrogenic doses of acetaminophen (APAP) was associated with increased AP-1 DNA binding activity in mouse liver.
AP-1 Binding (activity) of in liver associated with paracetamol
5) Confidence 0.36 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.55 Pain Relevance 0.53
The APAP-induced hepatic AP-1 DNA binding complex had affinity for both the consensus AP-1 and CRE sequences.
AP-1 Binding (affinity) of associated with paracetamol
6) Confidence 0.36 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.56 Pain Relevance 0.54
Acetaminophen-induced hepatotoxicity is associated with early changes in AP-1 DNA binding activity.
AP-1 Binding (activity) of associated with paracetamol and hepatotoxicity
7) Confidence 0.36 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Title Doc Link 8827825 Disease Relevance 0.46 Pain Relevance 0.45
In the present studies, we determined that exposure to necrogenic doses of acetaminophen (APAP) was associated with increased AP-1 DNA binding activity in mouse liver.
AP-1 Binding (binding) of in liver associated with paracetamol
8) Confidence 0.36 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.55 Pain Relevance 0.53
Acetaminophen-induced hepatotoxicity is associated with early changes in AP-1 DNA binding activity.
AP-1 Binding (binding) of associated with paracetamol and hepatotoxicity
9) Confidence 0.36 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Title Doc Link 8827825 Disease Relevance 0.46 Pain Relevance 0.45
AP-1 is usually expressed at low basal cellular levels, but can be up-regulated by a variety of exogenous stimuli which results in synthesis of Fos and Jun proteins and increased AP-1 DNA binding activity.
AP-1 Binding (binding) of
10) Confidence 0.36 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.35 Pain Relevance 0.39
AP-1 is usually expressed at low basal cellular levels, but can be up-regulated by a variety of exogenous stimuli which results in synthesis of Fos and Jun proteins and increased AP-1 DNA binding activity.
AP-1 Binding (activity) of
11) Confidence 0.36 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.35 Pain Relevance 0.40
AP-1 binding to TREs also is induced by growth factors, cytokines and oncoproteins, leading to the general view that activation of AP-1 is oncogenic by contributing to proliferation, survival and transformation of cells.
AP-1 Binding (binding) of associated with cytokine
12) Confidence 0.36 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.16 Pain Relevance 0.05
DEM, APAP, and CCl(4) increased c-jun and c-fos mRNA levels, together with an increase in AP-1 binding; BSO failed to induce AP-1 despite an increase in c-fos.
AP-1 Binding (binding) of
13) Confidence 0.35 Published 2000 Journal Hepatology Section Abstract Doc Link 10915739 Disease Relevance 0.30 Pain Relevance 0.08
In the present study, we examined the effect of the KD on the increase of PENK, Fos, Jun, AP-1 DNA-binding activity and JNK gene expression induced by KA in the mouse hippocampus.
Jun Binding (binding) of in hippocampus associated with hippocampus
14) Confidence 0.33 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.14 Pain Relevance 0.23
In addition, we have also found that KD diminished KA-induced AP-1 DNA-binding activity, Fos and Jun expression, and phoshorylated form of the three types of JNKs.
AP-1 Binding (activity) of
15) Confidence 0.33 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.11 Pain Relevance 0.24
In addition, we have also found that KD diminished KA-induced AP-1 DNA-binding activity, Fos and Jun expression, and phoshorylated form of the three types of JNKs.
Jun Binding (binding) of
16) Confidence 0.33 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.11 Pain Relevance 0.24
Overall, there were no significant variations in the early induction of several key transcription factors involved in the initiation of hepatocyte proliferation including c-Jun, c-Fos and c-Myc between Metwt/wt;Alb-Cre+/?
c-Jun Binding (initiation) of in hepatocyte
17) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0.04
The order of predominance for the different TREs was: cRel, v-Myb, CRE-BP1/c-Jun, USF, AP-1_Q2, Pax-6, AP-1_C, NF-kappaB_Q6, Efr-1, Egr-3, and AREB6 (Figure 6 and Table 1 [additional file 1]).


c-Jun Binding (v-Myb) of
18) Confidence 0.21 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0
The fact that DNA binding of both AP-1 and NF-?
AP-1 Binding (binding) of
19) Confidence 0.15 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535625 Disease Relevance 0.47 Pain Relevance 0
Ginsenosides attenuate methamphetamine-induced behavioral side effects in mice via activation of adenosine A2A receptors: possible involvements of the striatal reduction in AP-1 DNA binding activity and proenkephalin gene expression.
AP-1 Binding (binding) of associated with adenocard and enkephalin
20) Confidence 0.14 Published 2005 Journal Behav. Brain Res. Section Title Doc Link 15680202 Disease Relevance 0 Pain Relevance 0.46

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