INT64816

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 16.01
Pain Relevance 7.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Anatomy Link Frequency
photoreceptors 1
B cells 1
nucleus 1
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 31 99.84 Very High Very High Very High
cINOD 68 99.44 Very High Very High Very High
gABA 16 99.16 Very High Very High Very High
cytokine 141 99.04 Very High Very High Very High
tetrodotoxin 4 98.98 Very High Very High Very High
Morphine 75 98.78 Very High Very High Very High
Glutamate 34 98.24 Very High Very High Very High
Inflammation 524 97.92 Very High Very High Very High
Paracetamol 10 97.16 Very High Very High Very High
antagonist 35 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 585 99.84 Very High Very High Very High
Apoptosis 167 99.02 Very High Very High Very High
Necrosis 39 99.00 Very High Very High Very High
Infection 139 98.78 Very High Very High Very High
Stress 109 98.72 Very High Very High Very High
Cancer 176 98.64 Very High Very High Very High
Death 78 98.64 Very High Very High Very High
Hepatotoxicity 7 98.64 Very High Very High Very High
Sprains And Strains 132 98.12 Very High Very High Very High
Epstein-barr Virus 28 97.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed an early, steep rise in proinflammatory cytokine mRNA synthesis that essentially paralleled the synthesis of mRNA encoding the immediate early transcription factor Egr-1.
Transcription (synthesis) of immediate early associated with cytokine
1) Confidence 0.69 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.52 Pain Relevance 0.27
Furthermore, c-jun, but not c-fos, mRNA transcripts were transiently increased following exposure to hepatotoxic doses of APAP.
Transcription (transcripts) of c-jun associated with paracetamol
2) Confidence 0.69 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.57 Pain Relevance 0.54
However, another recent study demonstrated that AP-1 and NF-?
Transcription (demonstrated) of AP-1
3) Confidence 0.69 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.08 Pain Relevance 0.12
, and the immediate early transcription factor early growth response (Egr)-1 [18] followed similar kinetics (Figure 4a).
Transcription (transcription) of immediate early
4) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.40 Pain Relevance 0.04
We observed an early, steep rise in proinflammatory cytokine mRNA synthesis that essentially paralleled the synthesis of mRNA encoding the immediate early transcription factor Egr-1.
Transcription (synthesis) of immediate early associated with cytokine
5) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.52 Pain Relevance 0.27
A single injection of morphine alters striatal expression of some genes in mice, including immediate early genes as well as transcription of cytoskeleton-related genes and proteins involved in oxidative chain [18,19].
Transcription (transcription) of immediate early associated with morphine
6) Confidence 0.52 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.05 Pain Relevance 1.07
At 2 h post infection, both TTX and GABA significantly up-regulated the levels of transcription for the viral immediate early (IE) genes ICP0, ICP4, and ICP27, as revealed by real time PCR.
Transcription (transcription) of immediate early associated with tetrodotoxin, gaba and infection
7) Confidence 0.52 Published 2005 Journal J. Neurovirol. Section Abstract Doc Link 16036805 Disease Relevance 0.55 Pain Relevance 0.60
Induction of EBV and KSHV replication in latently infected B cells appears to be driven by the plasma cell-specific transcription factor XBP-1s, which activates transcription of the viral immediate-early genes encoding the critical transcriptional activators that trigger the EBV and KSHV replication cascades (BZLF1 and BRLF1/gene 50 in the EBV genome and gene 50 in the KSHV genome) [8],[9],[10],[11],[12].
Transcription (transcription) of immediate-early in B cells associated with epstein-barr virus
8) Confidence 0.52 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.70 Pain Relevance 0
DEM, APAP, and CCl(4) increased c-jun and c-fos mRNA levels, together with an increase in AP-1 binding; BSO failed to induce AP-1 despite an increase in c-fos.
Transcription (levels) of c-jun
9) Confidence 0.50 Published 2000 Journal Hepatology Section Abstract Doc Link 10915739 Disease Relevance 0.30 Pain Relevance 0.08
The proto-oncogene c-fos encodes a nuclear phosphoprotein (c-Fos). c-Fos, in a complex with products of another proto-oncogene, c-jun (AP-1), regulates the expression of AP-1 binding genes at the transcriptional level [8].
Transcription (transcriptional) of AP-1
10) Confidence 0.49 Published 2010 Journal Virol J Section Body Doc Link PMC2976746 Disease Relevance 1.50 Pain Relevance 0.43
have been shown to inhibit TPA-induced AP-1 transcriptional
Transcription (transcriptional) of AP-1
11) Confidence 0.40 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1082887 Disease Relevance 0.34 Pain Relevance 0
NSAIDs are able to inactivate the transcription NF-kB and activator protein-1 (AP-1), critically involved in the induction of multiple inflammatory gene products involved in the inflammatory response (i.e. iNOS, TNF-?).
Transcription (transcription) of AP-1 associated with inflammatory response, inflammation and cinod
12) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.60 Pain Relevance 0.48
NSAIDs are able to inactivate the transcription NF-kB and activator protein-1 (AP-1), critically involved in the induction of multiple inflammatory gene products involved in the inflammatory response (i.e. iNOS, TNF-?).
Transcription (transcription) of activator protein-1 associated with inflammatory response, inflammation and cinod
13) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.60 Pain Relevance 0.48
ligands may be due to their ability to inhibit the activity of key transcription factors such as activator protein-1 (AP-1) and nuclear factor ?
Transcription (transcription) of activator protein-1
14) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526548 Disease Relevance 0.64 Pain Relevance 0.49
ligands may be due to their ability to inhibit the activity of key transcription factors such as activator protein-1 (AP-1) and nuclear factor ?
Transcription (transcription) of AP-1
15) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526548 Disease Relevance 0.65 Pain Relevance 0.49
Components of the transcriptional complex AP-1 (Fos, Fosb) exhibited gene expression pattern A.
Transcription (transcriptional) of AP-1
16) Confidence 0.17 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.07 Pain Relevance 0.04
Furthermore, the transcriptional activity of c-Jun and cFos can be inhibited by retinoic acid receptors in response to their ligands [49].
Transcription (activity) of c-Jun
17) Confidence 0.16 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.16 Pain Relevance 0
with the activity of many proinflammatory transcription factors including signal transducer and activator of transcription (Stat), Activator protein-1 (AP-1), and NF-?
Transcription (transcription) of Activator protein-1
18) Confidence 0.13 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.59 Pain Relevance 0.24
with the activity of many proinflammatory transcription factors including signal transducer and activator of transcription (Stat), Activator protein-1 (AP-1), and NF-?
Transcription (transcription) of AP-1
19) Confidence 0.13 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.59 Pain Relevance 0.24
It also contains a variety of transcription factor binding sites, including those for Sp1, GATA-1, AP1, AP2, CREB, estrogen and glucocorticoid receptors, NF?
Transcription (transcription) of AP1
20) Confidence 0.13 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.55 Pain Relevance 0

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