INT64817

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 6.78
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Anatomy Link Frequency
liver 4
brains 4
striatum 2
hippocampus 2
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 32 99.98 Very High Very High Very High
Hippocampus 19 97.76 Very High Very High Very High
Inflammatory response 10 97.68 Very High Very High Very High
Inflammation 31 93.60 High High
Eae 1 93.48 High High
metalloproteinase 6 84.08 Quite High
Opioid 4 82.12 Quite High
antagonist 3 78.88 Quite High
adenocard 4 75.00 Quite High
Migraine 5 69.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 43 97.28 Very High Very High Very High
Burns 111 97.24 Very High Very High Very High
Hepatotoxicity 33 96.80 Very High Very High Very High
Injury 63 94.52 High High
Spinocerebellar Ataxia Type 2 94 93.84 High High
Disease 91 93.68 High High
Apoptosis 25 82.28 Quite High
Breast Cancer 11 81.76 Quite High
Necrosis 7 76.96 Quite High
Convulsion 8 76.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The APAP-induced hepatic AP-1 DNA binding complex had affinity for both the consensus AP-1 and CRE sequences.
Positive_regulation (induced) of AP-1 Binding (complex) of associated with paracetamol
1) Confidence 0.69 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.56 Pain Relevance 0.54
Recent studies support the complexity of the interactions between AP-1 and NF-?
Positive_regulation (support) of AP-1 Binding (interactions) of
2) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.16 Pain Relevance 0.15
Recent studies support the complexity of the interactions between AP-1 and NF-?
Positive_regulation (between) of AP-1 Binding (interactions) of
3) Confidence 0.50 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.16 Pain Relevance 0.15
DEM, APAP, and CCl(4) increased c-jun and c-fos mRNA levels, together with an increase in AP-1 binding; BSO failed to induce AP-1 despite an increase in c-fos.
Positive_regulation (increase) of AP-1 Binding (binding) of
4) Confidence 0.47 Published 2000 Journal Hepatology Section Abstract Doc Link 10915739 Disease Relevance 0.30 Pain Relevance 0.08
AP-1 is usually expressed at low basal cellular levels, but can be up-regulated by a variety of exogenous stimuli which results in synthesis of Fos and Jun proteins and increased AP-1 DNA binding activity.
Positive_regulation (increased) of AP-1 Binding (activity) of
5) Confidence 0.47 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.35 Pain Relevance 0.40
AP-1 is usually expressed at low basal cellular levels, but can be up-regulated by a variety of exogenous stimuli which results in synthesis of Fos and Jun proteins and increased AP-1 DNA binding activity.
Positive_regulation (increased) of AP-1 Binding (binding) of
6) Confidence 0.47 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.35 Pain Relevance 0.39
In the present studies, we determined that exposure to necrogenic doses of acetaminophen (APAP) was associated with increased AP-1 DNA binding activity in mouse liver.
Positive_regulation (increased) of AP-1 Binding (binding) of in liver associated with paracetamol
7) Confidence 0.47 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.55 Pain Relevance 0.53
In the present studies, we determined that exposure to necrogenic doses of acetaminophen (APAP) was associated with increased AP-1 DNA binding activity in mouse liver.
Positive_regulation (increased) of AP-1 Binding (activity) of in liver associated with paracetamol
8) Confidence 0.47 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.55 Pain Relevance 0.53
In addition, we have also found that KD diminished KA-induced AP-1 DNA-binding activity, Fos and Jun expression, and phoshorylated form of the three types of JNKs.
Positive_regulation (induced) of AP-1 Binding (activity) of
9) Confidence 0.43 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.11 Pain Relevance 0.24
In the present study, we examined the effect of the KD on the increase of PENK, Fos, Jun, AP-1 DNA-binding activity and JNK gene expression induced by KA in the mouse hippocampus.
Spec (examined) Positive_regulation (increase) of Jun Binding (binding) of in hippocampus associated with hippocampus
10) Confidence 0.43 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.14 Pain Relevance 0.24
Our results suggest that the stimulation of A2A receptors by ginsenosides attenuates the changes in behavior and the increases in AP-1 DNA binding activity, FRA-IR, and proenkephalin gene expression in mouse striatum that are induced by MA.
Positive_regulation (increases) of AP-1 Binding (activity) of in striatum
11) Confidence 0.19 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15680202 Disease Relevance 0 Pain Relevance 0.25
Third, although both promoters have several cis-acting elements such as CAAT box, AP-1 and NF-?
Positive_regulation (cis-acting) of AP-1 Binding (box) of
12) Confidence 0.07 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.07 Pain Relevance 0.06
B but increased AP-1 DNA-binding activity of intestinal mucosa in thermal injured mice compared with those of burn group.
Positive_regulation (increased) of AP-1 Binding (activity) of associated with burns
13) Confidence 0.07 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.28 Pain Relevance 0.05
These alterations may well be relevant to the therapeutic effects of valproate, and result from its enhancement of activator protein-1 DNA binding and direct inhibition of histone deacetylases, and possibly additional, yet unknown, mechanism(s).
Positive_regulation (enhancement) of activator protein-1 Binding (binding) of
14) Confidence 0.07 Published 2007 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 17514356 Disease Relevance 0.21 Pain Relevance 0.07
that affect gene expression, and chronic lithium treatment has been reported to increase the DNA binding activity of the transcription factor AP-1 in rat brains [30].
Positive_regulation (increase) of AP-1 Binding (activity) of in brains
15) Confidence 0.06 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0.66 Pain Relevance 0.03
that affect gene expression, and chronic lithium treatment has been reported to increase the DNA binding activity of the transcription factor AP-1 in rat brains [30].
Positive_regulation (increase) of AP-1 Binding (binding) of in brains
16) Confidence 0.06 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 0.66 Pain Relevance 0.03
-catenin and on the other hand, in the inhibition of c-jun phosphorylation leading to an increase in the DNA binding activity of AP-1.
Positive_regulation (increase) of AP-1 Binding (activity) of
17) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.67 Pain Relevance 0.07

General Comments

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