INT64818

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Context Info
Confidence 0.33
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Title
Documents 3
Total Number 4
Disease Relevance 1.06
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Anatomy Link Frequency
hepatocyte 2
hippocampus 2
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 99.02 Very High Very High Very High
Hippocampus 4 97.56 Very High Very High Very High
Opioid 1 83.08 Quite High
Inflammation 2 82.08 Quite High
cytokine 2 79.36 Quite High
Inflammatory response 2 57.92 Quite High
Enkephalin 2 25.00 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 10 99.48 Very High Very High Very High
INFLAMMATION 4 82.08 Quite High
Convulsion 1 77.20 Quite High
Epilepsy 1 66.52 Quite High
Necrosis 4 56.72 Quite High
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, there were no significant variations in the early induction of several key transcription factors involved in the initiation of hepatocyte proliferation including c-Jun, c-Fos and c-Myc between Metwt/wt;Alb-Cre+/?
Regulation (involved) of c-Jun Binding (initiation) of in hepatocyte
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0.04
Acetaminophen-induced hepatotoxicity is associated with early changes in AP-1 DNA binding activity.
Regulation (changes) of AP-1 Binding (binding) of associated with paracetamol and hepatotoxicity
2) Confidence 0.27 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Title Doc Link 8827825 Disease Relevance 0.46 Pain Relevance 0.45
Acetaminophen-induced hepatotoxicity is associated with early changes in AP-1 DNA binding activity.
Regulation (changes) of AP-1 Binding (activity) of associated with paracetamol and hepatotoxicity
3) Confidence 0.27 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Title Doc Link 8827825 Disease Relevance 0.46 Pain Relevance 0.45
In the present study, we examined the effect of the KD on the increase of PENK, Fos, Jun, AP-1 DNA-binding activity and JNK gene expression induced by KA in the mouse hippocampus.
Spec (examined) Regulation (effect) of Jun Binding (binding) of in hippocampus associated with hippocampus
4) Confidence 0.25 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.14 Pain Relevance 0.24

General Comments

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