INT64819

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.41
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Anatomy Link Frequency
nucleus 2
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 54 99.74 Very High Very High Very High
Paracetamol 7 98.24 Very High Very High Very High
Inflammation 120 97.92 Very High Very High Very High
Inflammatory response 3 96.20 Very High Very High Very High
cytokine 51 91.08 High High
Arthritis 84 89.28 High High
agonist 24 85.52 High High
ischemia 67 83.68 Quite High
bDMF 24 81.08 Quite High
chemokine 4 79.92 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 23 99.20 Very High Very High Very High
Death 11 98.64 Very High Very High Very High
INFLAMMATION 142 97.92 Very High Very High Very High
Parkinson's Disease 216 90.36 High High
Experimental Arthritis 4 90.32 High High
Necrosis 8 90.12 High High
Cancer 18 89.76 High High
Targeted Disruption 11 87.84 High High
Hepatotoxicity 5 87.00 High High
Cv General 4 Under Development 59 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, c-jun, but not c-fos, mRNA transcripts were transiently increased following exposure to hepatotoxic doses of APAP.
Positive_regulation (increased) of Transcription (transcripts) of c-jun associated with paracetamol
1) Confidence 0.50 Published 1996 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 8827825 Disease Relevance 0.58 Pain Relevance 0.54
have been shown to inhibit TPA-induced AP-1 transcriptional
Positive_regulation (induced) of Transcription (transcriptional) of AP-1
2) Confidence 0.29 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1082887 Disease Relevance 0.39 Pain Relevance 0
NSAIDs are able to inactivate the transcription NF-kB and activator protein-1 (AP-1), critically involved in the induction of multiple inflammatory gene products involved in the inflammatory response (i.e. iNOS, TNF-?).
Positive_regulation (inactivate) of Transcription (transcription) of AP-1 associated with inflammatory response, inflammation and cinod
3) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.61 Pain Relevance 0.48
NSAIDs are able to inactivate the transcription NF-kB and activator protein-1 (AP-1), critically involved in the induction of multiple inflammatory gene products involved in the inflammatory response (i.e. iNOS, TNF-?).
Positive_regulation (inactivate) of Transcription (transcription) of activator protein-1 associated with inflammatory response, inflammation and cinod
4) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.61 Pain Relevance 0.48
ligands may be due to their ability to inhibit the activity of key transcription factors such as activator protein-1 (AP-1) and nuclear factor ?
Positive_regulation (as) of Transcription (transcription) of activator protein-1
5) Confidence 0.13 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526548 Disease Relevance 0.64 Pain Relevance 0.49
ligands may be due to their ability to inhibit the activity of key transcription factors such as activator protein-1 (AP-1) and nuclear factor ?
Positive_regulation (as) of Transcription (transcription) of AP-1
6) Confidence 0.13 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526548 Disease Relevance 0.65 Pain Relevance 0.49
JNK is known to phosphorylate many cellular proteins, including several implicated in apoptosis, and can translocate to the nucleus to activate c-Jun and AP-1-mediated gene transcription, leading to transcription of pro-death genes [62].
Positive_regulation (activate) of Transcription (transcription) of c-Jun in nucleus associated with apoptosis and death
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.93 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox