INT6482

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2011
Negated 19
Speculated 20
Reported most in Abstract
Documents 659
Total Number 679
Disease Relevance 569.88
Pain Relevance 210.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophages 68
T cells 42
monocytes 34
mononuclear cells 28
blood 21
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10343 100.00 Very High Very High Very High
cytokine 8289 100.00 Very High Very High Very High
rheumatoid arthritis 6523 100.00 Very High Very High Very High
metalloproteinase 1132 100.00 Very High Very High Very High
chemokine 1052 100.00 Very High Very High Very High
methotrexate 775 100.00 Very High Very High Very High
antagonist 536 100.00 Very High Very High Very High
Inflammatory mediators 515 100.00 Very High Very High Very High
psoriasis 291 100.00 Very High Very High Very High
Leflunomide 61 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 11869 100.00 Very High Very High Very High
Rheumatoid Arthritis 6930 100.00 Very High Very High Very High
Disease 6623 100.00 Very High Very High Very High
Infection 3376 100.00 Very High Very High Very High
Cancer 2878 100.00 Very High Very High Very High
Obesity 1922 100.00 Very High Very High Very High
Necrosis 1488 100.00 Very High Very High Very High
Targeted Disruption 1458 100.00 Very High Very High Very High
Pressure And Volume Under Development 731 100.00 Very High Very High Very High
Adhesions 689 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of morphine's amplifying effect appears to be opioid receptor-mediated and to involve enhanced production of tumor necrosis factor-alpha by microglial cells.
Positive_regulation (enhanced) of Gene_expression (production) of tumor necrosis factor-alpha in microglial cells associated with necrosis, cancer, opioid receptor and morphine
1) Confidence 0.70 Published 1994 Journal J. Neuroimmunol. Section Abstract Doc Link 8120138 Disease Relevance 0.68 Pain Relevance 0.47
In addition, findings in recent studies involving human volunteers injected with endotoxin suggest that pretreatment with NSAIDs enhances production of tumor necrosis factor, which leads to higher blood levels of this cytokine, probably by preventing feedback inhibition by prostaglandin E2.
Positive_regulation (enhances) of Gene_expression (production) of tumor necrosis factor in blood associated with necrosis, cancer, cinod and cytokine
2) Confidence 0.70 Published 1995 Journal Clin. Infect. Dis. Section Abstract Doc Link 8645850 Disease Relevance 1.03 Pain Relevance 0.65
These findings suggest that morphine primes microglia for enhanced production of TNF-alpha which could alter several functional activities of these cells within the brain.
Positive_regulation (enhanced) of Gene_expression (production) of TNF-alpha in brain associated with morphine
3) Confidence 0.70 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8169825 Disease Relevance 0.32 Pain Relevance 0.76
Increased levels of tumor necrosis factor-alpha (TNF-alpha) have been found in, for example, inflammatory bowel disease (IBD) and human immunodeficiency virus (HIV) infection.
Positive_regulation (Increased) of Gene_expression (levels) of tumor necrosis factor-alpha in bowel associated with inflammatory bowel disease, necrosis, inflammation, cancer, acquired immune deficiency syndrome or hiv infection and infection
4) Confidence 0.70 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8897887 Disease Relevance 1.00 Pain Relevance 0.05
In addition, by facilitating endotoxin-induced TNFalpha expression, indomethacin or lysine-acetylsalicylic acid counteracted dexamethasone-induced inhibition of TNFalpha biosynthesis, thereby exhibiting an effect opposite to that of exogenous prostaglandin E(2).
Positive_regulation (induced) of Gene_expression (expression) of TNFalpha associated with aspirin and dexamethasone
5) Confidence 0.70 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.14 Pain Relevance 0.29
Indomethacin or lysine-acetylsalicylic acid concentration-dependently inhibited prostaglandin E(2) biosynthesis and, at concentrations causing near-complete inhibition, enhanced TNFalpha mRNA and protein expression without significantly influencing cyclooxygenase-2 mRNA.
Positive_regulation (enhanced) of Gene_expression (expression) of TNFalpha associated with aspirin
6) Confidence 0.70 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.15 Pain Relevance 0.28
Statistical analysis provided evidence of a significant increase of TNF-alpha gene expression associated with irreversible inflammation compared with healthy controls (P = 0.002).
Positive_regulation (increase) of Gene_expression (expression) of TNF-alpha
7) Confidence 0.69 Published 2007 Journal Int Endod J Section Body Doc Link 17305696 Disease Relevance 0 Pain Relevance 0
Irreversible but not reversible pulpitis is associated with up-regulation of tumour necrosis factor-alpha gene expression in human pulp.
Positive_regulation (regulation) of Gene_expression (expression) of tumour necrosis factor-alpha associated with necrosis, cancer and pulpitis
8) Confidence 0.69 Published 2007 Journal Int Endod J Section Title Doc Link 17305696 Disease Relevance 0.59 Pain Relevance 0.19
Nonsteroidal anti-inflammatory drugs increase tumor necrosis factor production in the periphery but not in the central nervous system in mice and rats.
Positive_regulation (increase) of Gene_expression (production) of tumor necrosis factor in central nervous system associated with necrosis, inflammation, cancer, cinod and central nervous system
9) Confidence 0.69 Published 1998 Journal J. Neurochem. Section Title Doc Link 9798931 Disease Relevance 0.78 Pain Relevance 0.70
However, NSAIDs (intraperitoneally or intracerebroventricularly) did not increase brain TNF production induced by intravenous LPS.
Neg (not) Positive_regulation (induced) of Gene_expression (production) of TNF in brain associated with cinod
10) Confidence 0.69 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9798931 Disease Relevance 0.73 Pain Relevance 0.72
Nonsteroidal anti-inflammatory drugs (NSAIDs), which inhibit prostaglandin (PG) synthesis, augment production of tumor necrosis factor (TNF) in most experimental models.
Positive_regulation (augment) of Gene_expression (production) of TNF associated with necrosis, inflammation, cancer and cinod
11) Confidence 0.69 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9798931 Disease Relevance 0.59 Pain Relevance 0.54
However, NSAIDs (intraperitoneally or intracerebroventricularly) did not increase brain TNF production induced by intravenous LPS.
Neg (not) Positive_regulation (increase) of Gene_expression (production) of TNF in brain associated with cinod
12) Confidence 0.69 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9798931 Disease Relevance 0.73 Pain Relevance 0.72
The addition of sera from healthy controls to the co-cultures was found to inhibit T cell induced production of TNF-?
Positive_regulation (induced) of Gene_expression (production) of TNF in T cell
13) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.79 Pain Relevance 0.36
As for mechanisms of action, KT-90 and morphine induced apoptosis, and inhibited tumor necrosis factor alpha (TNF-alpha) gene expression induced by tumor promoters, okadaic acid and 12-O-tetradecanoylphorbol-13-acetate, associated with reduction of NF-kappaB DNA binding activity.
Positive_regulation (induced) of Gene_expression (expression) of tumor necrosis factor alpha associated with necrosis, cancer, apoptosis and morphine
14) Confidence 0.68 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9837747 Disease Relevance 0.65 Pain Relevance 0.78
As it appears logical that patients producing high levels of TNF?
Positive_regulation (levels) of Gene_expression (producing) of TNF
15) Confidence 0.68 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564801 Disease Relevance 0.45 Pain Relevance 0.29
However, no increase in TNF receptor I gene or protein expression was observed in degenerate or herniated IVDs compared to non-degenerate IVDs.
Neg (no) Positive_regulation (increase) of Gene_expression (expression) of TNF
16) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206382 Disease Relevance 0.18 Pain Relevance 0.24
However, no increase in TNF RI synthesis was seen during IVD degeneration or herniation.
Neg (no) Positive_regulation (increase) of Gene_expression (synthesis) of TNF
17) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206382 Disease Relevance 0 Pain Relevance 0.03
Because of recent findings associating human TNF alpha mutant alleles at the -308 position with increased production of TNF alpha in many immunological and infectious diseases, an investigation of the role of TNF2 in predisposing leprosy patients to reaction has been undertaken.
Positive_regulation (increased) of Gene_expression (production) of TNF alpha associated with mycobacterium infection and communicable diseases
18) Confidence 0.67 Published 2000 Journal Lepr Rev Section Abstract Doc Link 11201873 Disease Relevance 0.94 Pain Relevance 0.10
It also increased leucocyte counts, changed percentages of certain subsets of lymphocytes [43], and increased levels of IL-6 [39,46] and TNF-?
Positive_regulation (increased) of Gene_expression (levels) of TNF in lymphocytes
19) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911873 Disease Relevance 1.96 Pain Relevance 0.36
Cultured rat microglia treated with 1 mM ATP, for example, increase expression of TNF?
Positive_regulation (increase) of Gene_expression (expression) of TNF in microglia
20) Confidence 0.67 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.25

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