INT64821

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.08
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SLPI) enzyme binding (SLPI)
Anatomy Link Frequency
plasma 1
hearts 1
SLPI (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 100 100.00 Very High Very High Very High
ischemia 94 100.00 Very High Very High Very High
imagery 56 100.00 Very High Very High Very High
metalloproteinase 14 100.00 Very High Very High Very High
Pain 14 94.80 High High
headache 1 90.96 High High
MU agonist 2 77.12 Quite High
Enkephalin 2 74.56 Quite High
anesthesia 1 65.84 Quite High
Angina 5 50.00 Quite Low
Disease Link Frequency Relevance Heat
Frailty 103 100.00 Very High Very High Very High
Cv Unclassified Under Development 85 100.00 Very High Very High Very High
Stress 45 99.98 Very High Very High Very High
Pathologic Constriction 165 98.16 Very High Very High Very High
Disorder Of Lipid Metabolism 6 96.52 Very High Very High Very High
Infection 2 95.08 Very High Very High Very High
Peripheral Arterial Disease 1 94.44 High High
Cv General 3 Under Development 3 92.52 High High
Pleural Effusion 5 91.28 High High
Headache 1 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical examination revealed significant elevations of LDH, CRP, ALP and UA.
Positive_regulation (elevations) of ALP
1) Confidence 0.67 Published 2003 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 12852351 Disease Relevance 0.34 Pain Relevance 0.18
The serum LDH, GOT, GPT, ALP and gamma-GTP levels were elevated, and antibodies to Epstein-Barr viral capsid, early, and nuclear antigens were diagnostic of a primary Epstein-Barr virus infection.
Positive_regulation (elevated) of ALP associated with infection
2) Confidence 0.56 Published 1996 Journal Rinsho Ketsueki Section Abstract Doc Link 8827884 Disease Relevance 0.52 Pain Relevance 0.09
Likewise, C57BL/6 mice fed a HFD showed elevated ALT, AST and ALK plasma concentrations indicating alteration of the hepatic and pancreatic function.
Positive_regulation (elevated) of ALK in plasma
3) Confidence 0.49 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 1.34 Pain Relevance 0
Alkaline phosphatase (ALP) increased gradually after starting ATD therapy and maintained an elevated value for 3-5 months in Graves' disease.
Positive_regulation (increased) of ALP
4) Confidence 0.45 Published 2008 Journal Thyroid Section Body Doc Link 18001177 Disease Relevance 0 Pain Relevance 0
We show similar upregulation of two further anti-angiogenic protease inhibitors in OA, TIMP-3 and SLPI, with comparable expression patterns to TIMP-1.
Positive_regulation (upregulation) of SLPI associated with osteoarthritis
5) Confidence 0.42 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2877870 Disease Relevance 0.41 Pain Relevance 0.14
METHODS: Three hundred and eighty-four patients (58.0+/-8.8 years) referred for angiography underwent MPI.
Positive_regulation (underwent) of MPI
6) Confidence 0.40 Published 2005 Journal Eur. J. Nucl. Med. Mol. Imaging Section Body Doc Link 15824925 Disease Relevance 0.09 Pain Relevance 0
Scores for VEGF, TIMP-1, TIMP-3, SLPI and PAI-1 were all increased in OA compared with PM, and higher scores were associated with greater chondropathy.
Positive_regulation (increased) of SLPI associated with osteoarthritis
7) Confidence 0.14 Published 2010 Journal Osteoarthritis and Cartilage Section Abstract Doc Link PMC2877870 Disease Relevance 0.45 Pain Relevance 0.19
While the stenosis category 50-69% was usually not associated with ischemia, 17% of these patients manifested stress-induced ischemia on SPECT-MPI as noted above.FigureĀ 2Comparison of maximal stenosis detected by CCTA and TPD quantified by SPECT-MPI and expressed as percent perfusion defect on a continuous scale.
Positive_regulation (induced) of SPECT-MPI associated with stress, pathologic constriction, ischemia and imagery
8) Confidence 0.08 Published 2010 Journal J Nucl Cardiol Section Body Doc Link PMC2940027 Disease Relevance 1.64 Pain Relevance 0.33
Isoniazid-treated animals showed a marked increase in the level of marker enzymes AST, ALT, ALP, and bilirubin total and direct [Table 1].
Positive_regulation (increase) of ALP
9) Confidence 0.03 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991701 Disease Relevance 0.16 Pain Relevance 0.07
ACh caused a 36 +/- 6% increase in fluorescence (P<0.001) and metalloproteinase inhibitor III (MPI) abolished this increase.
Positive_regulation (increase) of MPI associated with metalloproteinase
10) Confidence 0.02 Published 2004 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15010282 Disease Relevance 0 Pain Relevance 0.17
In isolated, perfused rabbit hearts ACh increased phosphorylation of EGFR by 127.4 +/- 43.7%, and this increase was abolished by MPI.
Positive_regulation (increase) of MPI in hearts
11) Confidence 0.02 Published 2004 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15010282 Disease Relevance 0.13 Pain Relevance 0.32

General Comments

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