INT64824

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Context Info
Confidence 0.42
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 23
Disease Relevance 18.70
Pain Relevance 5.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
abdomen 1
muscle 1
nasal 1
LHA 1
vagus nerve 1
sar (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 1 100.00 Very High Very High Very High
syringomyelia 1066 99.60 Very High Very High Very High
bradykinin 9 99.28 Very High Very High Very High
lidocaine 5 99.18 Very High Very High Very High
halothane 5 99.16 Very High Very High Very High
vagus nerve 3 97.82 Very High Very High Very High
headache 2 96.12 Very High Very High Very High
agonist 4 91.92 High High
imagery 234 90.44 High High
diclofenac 3 87.48 High High
Disease Link Frequency Relevance Heat
Scoliosis 1274 100.00 Very High Very High Very High
Rhinitis 13 100.00 Very High Very High Very High
Hypotension 6 99.98 Very High Very High Very High
Abnormal Reflex 221 99.84 Very High Very High Very High
Syringomyelia 1066 99.60 Very High Very High Very High
Increased Venous Pressure Under Development 1 97.20 Very High Very High Very High
Xerostomia 2 96.72 Very High Very High Very High
Headache 2 96.12 Very High Very High Very High
Sleep Disorders 1 95.72 Very High Very High Very High
Obesity 1 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The efficacy of ebastine 10 mg/day (n = 111) was similar to that of astemizole 10 mg/day (n = 106) over a 4-month period in preventing the symptoms of SAR in the open randomised study.
Negative_regulation (preventing) of SAR associated with rhinitis
1) Confidence 0.42 Published 1996 Journal Drugs Section Abstract Doc Link 8828025 Disease Relevance 0.98 Pain Relevance 0.12
Desloratadine/pseudoephedrine, 2.5/120 mg b.i.d., therapy was more effective in reducing total symptom scores of SAR, including nasal congestion, than were the individual components.
Negative_regulation (reducing) of SAR in nasal associated with rhinitis
2) Confidence 0.42 Published 2005 Journal Allergy Asthma Proc Section Abstract Doc Link 16450574 Disease Relevance 0.65 Pain Relevance 0.10
In anesthetized, artificially ventilated rabbits with vagus nerve section, inhalation of CO(2) gas mixtures (tracheal CO(2) concentration ranging from 8.0 to 10.2%) for 60 s decreased slowly adapting pulmonary stretch receptor (SAR) activity during both inflation and deflation.
Negative_regulation (decreased) of SAR in vagus nerve associated with vagus nerve
3) Confidence 0.38 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10454467 Disease Relevance 0 Pain Relevance 0.09
A: Bilateral absence of SAR.
Negative_regulation (absence) of SAR
4) Confidence 0.36 Published 2010 Journal Scoliosis Section Body Doc Link PMC2939502 Disease Relevance 1.14 Pain Relevance 0.21
Absence of SAR was defined as no movement of the umbilicus.
Negative_regulation (Absence) of SAR
5) Confidence 0.36 Published 2010 Journal Scoliosis Section Body Doc Link PMC2939502 Disease Relevance 1.03 Pain Relevance 0.19
In the present study, we found that abnormal SAR (defined as unilateral or bilateral absence of SAR or hyporeflexia as found by a single experienced examiner) yielded 89% sensitivity for syringomyelia.
Negative_regulation (absence) of SAR associated with syringomyelia and abnormal reflex
6) Confidence 0.36 Published 2010 Journal Scoliosis Section Body Doc Link PMC2939502 Disease Relevance 1.31 Pain Relevance 0.27
All cases of myopathic scoliosis had bilateral absence of SAR.
Negative_regulation (absence) of SAR associated with scoliosis
7) Confidence 0.36 Published 2010 Journal Scoliosis Section Body Doc Link PMC2939502 Disease Relevance 1.72 Pain Relevance 0.41
All six patients with bilateral absence of SAR had myopathic scoliosis.
Negative_regulation (absence) of SAR associated with scoliosis
8) Confidence 0.36 Published 2010 Journal Scoliosis Section Body Doc Link PMC2939502 Disease Relevance 1.17 Pain Relevance 0.24
Six patients had unilateral absence of SAR; 2 had absence of SAR on the side of abdominal surgery, and the other 4 patients had syringomyelia.
Negative_regulation (absence) of SAR associated with syringomyelia
9) Confidence 0.36 Published 2010 Journal Scoliosis Section Body Doc Link PMC2939502 Disease Relevance 1.32 Pain Relevance 0.25
All 6 patients with myopathic scoliosis displayed bilateral absence of SAR.
Negative_regulation (absence) of SAR associated with scoliosis
10) Confidence 0.36 Published 2010 Journal Scoliosis Section Abstract Doc Link PMC2939502 Disease Relevance 1.74 Pain Relevance 0.38
Saifuddin concluded that unilateral absence of SAR was a significant sign suggestive of syringomyelia and that bilateral absence of SAR might also be associated with neuraxis anomalies [32].
Negative_regulation (absence) of SAR associated with syringomyelia
11) Confidence 0.36 Published 2010 Journal Scoliosis Section Body Doc Link PMC2939502 Disease Relevance 1.03 Pain Relevance 0.39
Saifuddin concluded that unilateral absence of SAR was a significant sign suggestive of syringomyelia and that bilateral absence of SAR might also be associated with neuraxis anomalies [32].
Negative_regulation (absence) of SAR associated with syringomyelia
12) Confidence 0.36 Published 2010 Journal Scoliosis Section Body Doc Link PMC2939502 Disease Relevance 1.05 Pain Relevance 0.41
Six patients had unilateral absence of SAR; 2 had absence of SAR on the side of abdominal surgery, and the other 4 patients had syringomyelia.
Negative_regulation (absence) of SAR associated with syringomyelia
13) Confidence 0.31 Published 2010 Journal Scoliosis Section Body Doc Link PMC2939502 Disease Relevance 1.30 Pain Relevance 0.25
Furthermore, if SAR of a patient with scoliosis is abnormal, the patient has a 90% of probability of being non-idiopathic scoliosis (Table3).
Negative_regulation (abnormal) of SAR associated with scoliosis
14) Confidence 0.31 Published 2010 Journal Scoliosis Section Body Doc Link PMC2939502 Disease Relevance 1.43 Pain Relevance 0.30
However, as a limitation of these studies, they might have differed in their definition of "idiopathic" or "abnormal SAR".
Negative_regulation (definition) of SAR
15) Confidence 0.31 Published 2010 Journal Scoliosis Section Body Doc Link PMC2939502 Disease Relevance 1.13 Pain Relevance 0.34
Normal SAR was defined as clear deviation of SAR on both sides of the abdomen, and abnormal SAR was defined as absence or hyporeflexia of SAR on one or both sides of the abdomen (including unilateral hyporeflexia or absence and bilateral hyporeflexia or absence).
Negative_regulation (defined) of SAR in abdomen associated with abnormal reflex
16) Confidence 0.31 Published 2010 Journal Scoliosis Section Body Doc Link PMC2939502 Disease Relevance 0.87 Pain Relevance 0.13
Intravenous administration of 4-aminopyridine (0. 7 and 2.0 mg/kg i.v.), a K(+) channel blocker, which dose-dependently increased SAR activity during deflation and had no effect on P(T), abolished or attenuated the decrease in SAR activities induced by CO(2) inhalation in a dose-dependent manner.
Negative_regulation (decrease) of SAR
17) Confidence 0.28 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10454467 Disease Relevance 0 Pain Relevance 0.07
Intravenous lidocaine (1 mg.kg(-1) or 2 mg.kg(-1)) produced a suppression of SAR activity but not of RAR activity.
Negative_regulation (suppression) of SAR associated with lidocaine
18) Confidence 0.27 Published 1992 Journal J Anesth Section Abstract Doc Link 15278511 Disease Relevance 0.08 Pain Relevance 0.43
Veratridine usually inhibited SAR activity in ouabain-treated animals, irrespective of the difference of ouabain effects.
Negative_regulation (inhibited) of SAR
19) Confidence 0.22 Published 1998 Journal Life Sci. Section Abstract Doc Link 9952289 Disease Relevance 0 Pain Relevance 0.04
Absorbers of 9 x 9 x 4 cm3 and a salinity of 18 gram l(-1) provide a SAR reduction in the muscle equivalent material, centrally under the absorber of at least 50% at a depth of up to 3 cm.
Negative_regulation (reduction) of SAR in muscle
20) Confidence 0.18 Published 2001 Journal Int J Hyperthermia Section Abstract Doc Link 11347729 Disease Relevance 0.41 Pain Relevance 0.08

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