INT64825

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.59
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Nanog) nucleoplasm (Nanog) nucleolus (Nanog)
nucleus (Nanog) embryo development (Nanog) DNA binding (Nanog)
Anatomy Link Frequency
neurons 1
brains 1
pallidum 1
neural 1
Nanog (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 36 100.00 Very High Very High Very High
substance P 3 98.48 Very High Very High Very High
Neuropeptide 8 95.52 Very High Very High Very High
Substantia nigra 1 93.52 High High
Delta opioid receptors 3 91.56 High High
tolerance 1 84.60 Quite High
addiction 2 84.04 Quite High
projection neuron 3 84.00 Quite High
Morphine 2 83.60 Quite High
opioid receptor 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 12 99.76 Very High Very High Very High
Targeted Disruption 8 99.58 Very High Very High Very High
Disease 8 94.28 High High
Cancer 7 89.28 High High
Teratoma 10 85.44 High High
Morphine Dependence 1 84.04 Quite High
Injury 18 25.04 Quite Low
Myocardial Infarction 13 24.76 Low Low
Cicatrix 9 5.00 Very Low Very Low Very Low
Infarction 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The processing of proenkephalin was impaired in PC1 KO mouse brains with a decrease in the level of Met-Enkephalin immunoreactivity (ir-Met-Enk) and an accumulation of higher molecular weight processing intermediates containing ir-Met-Enk.
Negative_regulation (decrease) of Enk in brains associated with targeted disruption and enkephalin
1) Confidence 0.57 Published 2005 Journal Biochemistry Section Abstract Doc Link 15779921 Disease Relevance 0.45 Pain Relevance 0.32
The results show that PPE mRNA level, the number of striatal neurons expressing PPE, and the staining intensity of fibers immunoreactive for ENK in the pallidum were all decreased.
Negative_regulation (decreased) of ENK in pallidum associated with enkephalin
2) Confidence 0.41 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12586547 Disease Relevance 0.65 Pain Relevance 0.58
The Ca2+ channel currents were reduced reversibly by 40-60% in the presence of 1 microM leucine-enkephalin (Leu-Enk).
Negative_regulation (reduced) of Enk associated with enkephalin
3) Confidence 0.41 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15542741 Disease Relevance 0.08 Pain Relevance 0.42
In contrast to neural cell counts, the level of ENK transcript was decreased in the BLA and CEA of 'high-anxiety' mice after TMT exposure and LD testing.
Negative_regulation (decreased) of ENK in neural associated with anxiety disorder and enkephalin
4) Confidence 0.41 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525282 Disease Relevance 0.53 Pain Relevance 0.90
In contrast, colonies of undifferentiated ESCs and high expression levels of Nanog and Pou5f1 were found in cultures of the sorted GFP(?)
Negative_regulation (levels) of Nanog
5) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.34 Pain Relevance 0
This result indicated that the human cerebellum possesses ENK positive fibers and neurons before birth.
Negative_regulation (possesses) of ENK in neurons associated with enkephalin
6) Confidence 0.31 Published 1996 Journal Int. J. Neurosci. Section Abstract Doc Link 8828056 Disease Relevance 0 Pain Relevance 0.34
In the BLA and CEA, 'high-anxiety' mice also displayed increased FRA/ENK after TMT exposure and LD testing.
Negative_regulation (displayed) of ENK associated with anxiety disorder and enkephalin
7) Confidence 0.18 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525282 Disease Relevance 0.53 Pain Relevance 0.92
GF-iPS-3F showed a greater decrease in the CpG methylation ratio in the promoter regions of Nanog and Oct3/4 in comparison to GF-iPS-4F cells that resulted in a methylation pattern similar to that of mouse ES cells.
Negative_regulation (decrease) of Nanog
8) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0

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