INT64827

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Context Info
Confidence 0.36
First Reported 1996
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 6.57
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mast cells 3
molar 1
Il2ra (Mus musculus)
Pain Link Frequency Relevance Heat
spastic colon 3 100.00 Very High Very High Very High
Bile 3 100.00 Very High Very High Very High
Antinociceptive 4 90.76 High High
Inflammation 9 89.88 High High
Inflammatory mediators 3 85.16 High High
antinociception 2 75.00 Quite High
Sciatic nerve 1 50.00 Quite Low
Pain 1 25.00 Low Low
nociceptor 1 25.00 Low Low
local anesthetic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gastritis 9 100.00 Very High Very High Very High
Parasitic Infection 9 100.00 Very High Very High Very High
Crohn's Disease 6 100.00 Very High Very High Very High
Gastroenteritis 3 100.00 Very High Very High Very High
Functional Bowel Disorder 3 100.00 Very High Very High Very High
Celiac Disease 3 100.00 Very High Very High Very High
Collagenous Colitis 3 100.00 Very High Very High Very High
Bile Reflux 3 100.00 Very High Very High Very High
Rhinitis 3 100.00 Very High Very High Very High
Duodenitis 3 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a QTL analysis specifically tailored to existing mouse RI strains, we found associations at the 0.01 level on seven chromosomes with the most promising marker loci being Il2ra, Hbb, Hmg1rs7 and Gsl5 on chromosomes 2, 7, 16 and 19, respectively (P < 0.002).
Il2ra Binding (associations) of associated with sprains and strains
1) Confidence 0.36 Published 1996 Journal Brain Res. Section Abstract Doc Link 8828582 Disease Relevance 0.97 Pain Relevance 0.29
Seventeen GI biopsies from 6 patients with SM; 17 GI biopsies from 5 patients with UP; and 157 control cases including 10 each normal stomach, duodenum, terminal ileum, and colon, Helicobacter pylori gastritis, bile reflux gastropathy, peptic duodenitis, celiac disease, Crohn disease, ulcerative colitis, lymphocytic colitis, and collagenous colitis, 20 biopsies from 16 patients with irritable bowel syndrome, 8 biopsies from 5 patients with parasitic infections, and 9 biopsies from 7 patients with eosinophilic gastroenteritis were immunostained for mast cell tryptase, c-kit (CD117), and CD25.
CD25 Binding (including) of in mast cell associated with bile, crohn's disease, spastic colon, gastroenteritis, duodenitis, rhinitis, parasitic infection, celiac disease, collagenous colitis, lymphocytic colitis, systemic mastocytosis, urticaria pigmentosa and gastritis
2) Confidence 0.27 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18059223 Disease Relevance 3.02 Pain Relevance 0.30
Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis.
CD25 Binding (Immunoreactivity) of in mast cells associated with systemic mastocytosis
3) Confidence 0.26 Published 2007 Journal Am. J. Surg. Pathol. Section Title Doc Link 18059223 Disease Relevance 1.20 Pain Relevance 0.11
Immunoreactivity for CD25 in GI mucosal mast cells is specific for SM and can be used to confirm the diagnosis.
CD25 Binding (Immunoreactivity) of in mast cells associated with systemic mastocytosis
4) Confidence 0.26 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18059223 Disease Relevance 1.39 Pain Relevance 0.09
S50-R50HPb-CD and S75-R25HPb-CD complexes have decreased onset (p < 0.01 and p < 0.05, respectively), without changing motor block intensity (Emax) as compared to plain drugs; ii) sensory block evaluation has revealed higher analgesic intensity with S50-R50HPb-CD (2-fold, p < 0.001) and S75-R25HPb-CD (1.5-1.8-fold, p < 0.01 and p < 0.001, respectively) with both molar ratios (1:1 and 1:2, LA:CD), in addition to prolonging analgesic effect as compared to S50-R50 and S75-R25.
S75-R25HPb-CD Binding (complexes) of in molar
5) Confidence 0.03 Published 2005 Journal Rev Bras Anestesiol Section Body Doc Link 19471836 Disease Relevance 0 Pain Relevance 0

General Comments

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