INT6483

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2011
Negated 63
Speculated 88
Reported most in Abstract
Documents 3152
Total Number 3241
Disease Relevance 2515.62
Pain Relevance 929.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophages 162
T cells 81
monocytes 79
plasma 53
blood 41
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 47862 100.00 Very High Very High Very High
cytokine 38186 100.00 Very High Very High Very High
rheumatoid arthritis 26596 100.00 Very High Very High Very High
Arthritis 13994 100.00 Very High Very High Very High
Infliximab 8106 100.00 Very High Very High Very High
Adalimumab 5570 100.00 Very High Very High Very High
Pain 5231 100.00 Very High Very High Very High
Etanercept 4810 100.00 Very High Very High Very High
chemokine 4793 100.00 Very High Very High Very High
Inflammatory response 4787 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 54324 100.00 Very High Very High Very High
Disease 31380 100.00 Very High Very High Very High
Rheumatoid Arthritis 28501 100.00 Very High Very High Very High
Infection 17965 100.00 Very High Very High Very High
Cancer 16861 100.00 Very High Very High Very High
Apoptosis 13048 100.00 Very High Very High Very High
Arthritis 9907 100.00 Very High Very High Very High
Obesity 8679 100.00 Very High Very High Very High
Necrosis 7074 100.00 Very High Very High Very High
Death 6925 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tumor necrosis factor (TNF) is the protein produced by the activated macrophages with the ability to produce haemorrhagic necrosis of tumor, and in some cases complete tumor remission in vivo, as well as cytotoxicity of neoplastic cells in vitro.
Gene_expression (produced) of TNF in macrophages associated with necrosis and cancer
1) Confidence 0.78 Published 1995 Journal Prz. Lek. Section Abstract Doc Link 8834840 Disease Relevance 0.79 Pain Relevance 0.05
Tumor necrosis factor (TNF) is the protein produced by the activated macrophages with the ability to produce haemorrhagic necrosis of tumor, and in some cases complete tumor remission in vivo, as well as cytotoxicity of neoplastic cells in vitro.
Gene_expression (produced) of Tumor necrosis factor in macrophages associated with necrosis and cancer
2) Confidence 0.78 Published 1995 Journal Prz. Lek. Section Abstract Doc Link 8834840 Disease Relevance 0.79 Pain Relevance 0.05
The mechanism of morphine's amplifying effect appears to be opioid receptor-mediated and to involve enhanced production of tumor necrosis factor-alpha by microglial cells.
Gene_expression (production) of tumor necrosis factor-alpha in microglial cells associated with necrosis, cancer, opioid receptor and morphine
3) Confidence 0.78 Published 1994 Journal J. Neuroimmunol. Section Abstract Doc Link 8120138 Disease Relevance 0.68 Pain Relevance 0.47
Detection of tumor necrosis factor alpha in normal and inflamed human dental pulps.
Gene_expression (Detection) of tumor necrosis factor alpha in dental pulps associated with necrosis and cancer
4) Confidence 0.78 Published 2002 Journal Arch. Med. Res. Section Title Doc Link 12459320 Disease Relevance 0.30 Pain Relevance 0.09
More interestingly, thalidomide has shown the ability to suppress tumor necrosis factor alpha (TNF alpha) production and to modify the expression of TNF alpha induced adhesion molecules on endothelial cells and on human leukocytes.
Gene_expression (production) of TNF alpha in leukocytes associated with necrosis, cancer and adhesions
5) Confidence 0.78 Published 2002 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 12412207 Disease Relevance 0.90 Pain Relevance 0.15
More interestingly, thalidomide has shown the ability to suppress tumor necrosis factor alpha (TNF alpha) production and to modify the expression of TNF alpha induced adhesion molecules on endothelial cells and on human leukocytes.
Gene_expression (expression) of TNF alpha in leukocytes associated with necrosis, cancer and adhesions
6) Confidence 0.78 Published 2002 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 12412207 Disease Relevance 0.92 Pain Relevance 0.16
More interestingly, thalidomide has shown the ability to suppress tumor necrosis factor alpha (TNF alpha) production and to modify the expression of TNF alpha induced adhesion molecules on endothelial cells and on human leukocytes.
Gene_expression (production) of tumor necrosis factor alpha in leukocytes associated with necrosis, cancer and adhesions
7) Confidence 0.78 Published 2002 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 12412207 Disease Relevance 0.91 Pain Relevance 0.15
Local production of endogenous TNF-alpha may occur early in the pathogenic process.
Gene_expression (production) of TNF-alpha
8) Confidence 0.78 Published 2006 Journal Joint Bone Spine Section Abstract Doc Link 16046171 Disease Relevance 0.55 Pain Relevance 0.61
In addition, findings in recent studies involving human volunteers injected with endotoxin suggest that pretreatment with NSAIDs enhances production of tumor necrosis factor, which leads to higher blood levels of this cytokine, probably by preventing feedback inhibition by prostaglandin E2.
Gene_expression (production) of tumor necrosis factor in blood associated with necrosis, cancer, cinod and cytokine
9) Confidence 0.78 Published 1995 Journal Clin. Infect. Dis. Section Abstract Doc Link 8645850 Disease Relevance 1.02 Pain Relevance 0.65
These findings suggest that morphine primes microglia for enhanced production of TNF-alpha which could alter several functional activities of these cells within the brain.
Gene_expression (production) of TNF-alpha in brain associated with morphine
10) Confidence 0.78 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8169825 Disease Relevance 0.32 Pain Relevance 0.75
Priming effect of morphine on the production of tumor necrosis factor-alpha by microglia: implications in respiratory burst activity and human immunodeficiency virus-1 expression.
Gene_expression (production) of tumor necrosis factor in respiratory associated with necrosis, cancer, acquired immune deficiency syndrome or hiv infection and morphine
11) Confidence 0.78 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8169825 Disease Relevance 0.47 Pain Relevance 0.83
Increased levels of tumor necrosis factor-alpha (TNF-alpha) have been found in, for example, inflammatory bowel disease (IBD) and human immunodeficiency virus (HIV) infection.
Gene_expression (levels) of tumor necrosis factor-alpha in bowel associated with inflammatory bowel disease, necrosis, inflammation, cancer, acquired immune deficiency syndrome or hiv infection and infection
12) Confidence 0.78 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8897887 Disease Relevance 1.00 Pain Relevance 0.05
Increased levels of tumor necrosis factor-alpha (TNF-alpha) have been found in, for example, inflammatory bowel disease (IBD) and human immunodeficiency virus (HIV) infection.
Gene_expression (levels) of TNF-alpha in bowel associated with inflammatory bowel disease, necrosis, inflammation, cancer, acquired immune deficiency syndrome or hiv infection and infection
13) Confidence 0.78 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8897887 Disease Relevance 1.00 Pain Relevance 0.05
Indomethacin or lysine-acetylsalicylic acid concentration-dependently inhibited prostaglandin E(2) biosynthesis and, at concentrations causing near-complete inhibition, enhanced TNFalpha mRNA and protein expression without significantly influencing cyclooxygenase-2 mRNA.
Gene_expression (expression) of TNFalpha associated with aspirin
14) Confidence 0.78 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.15 Pain Relevance 0.28
The results suggest that in human endotoxin-stimulated monocytes, NSAIDs can enhance TNFalpha expression through inhibition of cyclooxygenase and the resulting decrease in prostanoid biosynthesis.
Gene_expression (expression) of TNFalpha in monocytes associated with cinod
15) Confidence 0.78 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.11 Pain Relevance 0.28
In addition, by facilitating endotoxin-induced TNFalpha expression, indomethacin or lysine-acetylsalicylic acid counteracted dexamethasone-induced inhibition of TNFalpha biosynthesis, thereby exhibiting an effect opposite to that of exogenous prostaglandin E(2).
Gene_expression (expression) of TNFalpha associated with aspirin and dexamethasone
16) Confidence 0.78 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.14 Pain Relevance 0.29
Similar results were obtained using the membrane-permeable cAMP analogue db-cAMP, which caused preferential inhibition of TNFalpha expression.
Gene_expression (expression) of TNFalpha
17) Confidence 0.78 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.16 Pain Relevance 0.25
In addition, by facilitating endotoxin-induced TNFalpha expression, indomethacin or lysine-acetylsalicylic acid counteracted dexamethasone-induced inhibition of TNFalpha biosynthesis, thereby exhibiting an effect opposite to that of exogenous prostaglandin E(2).
Gene_expression (biosynthesis) of TNFalpha associated with aspirin and dexamethasone
18) Confidence 0.78 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.13 Pain Relevance 0.29
Human endotoxin-stimulated adherent monocytes were used in order to determine whether or not NSAIDs influence cyclooxygenase-2 and/or tumor necrosis factor (TNF)alpha expression within the range of inhibitor concentrations that are required to suppress prostaglandin biosynthesis.
Gene_expression (expression) of TNF in monocytes associated with necrosis, cancer and cinod
19) Confidence 0.78 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.20 Pain Relevance 0.13
RESULTS: Colocalization studies by confocal fluorescence microscopy for S-100 and TNF-alpha showed expression of TNF-alpha in human Schwann cells.
Gene_expression (expression) of TNF-alpha in Schwann cells
20) Confidence 0.78 Published 2001 Journal Neurology Section Body Doc Link 11376190 Disease Relevance 0.15 Pain Relevance 0

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