INT6484

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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 122
Total Number 129
Disease Relevance 75.84
Pain Relevance 35.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
chondrocytes 4
plasma 4
synovial fluid 2
macrophages 1
anterior 1
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 2770 100.00 Very High Very High Very High
cytokine 1893 100.00 Very High Very High Very High
Inflammation 1874 100.00 Very High Very High Very High
antagonist 265 100.00 Very High Very High Very High
aspirin 51 100.00 Very High Very High Very High
depression 37 100.00 Very High Very High Very High
Inflammatory marker 25 100.00 Very High Very High Very High
Morphine 7 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
anakinra 178 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 2804 100.00 Very High Very High Very High
INFLAMMATION 2070 100.00 Very High Very High Very High
Cancer 381 100.00 Very High Very High Very High
Necrosis 174 100.00 Very High Very High Very High
Depression 38 100.00 Very High Very High Very High
Burning Mouth Syndrome 20 100.00 Very High Very High Very High
Sprains And Strains 11 100.00 Very High Very High Very High
Injury 216 99.84 Very High Very High Very High
Temporomandibular Joint Syndrome 35 99.76 Very High Very High Very High
Lung Injury 4 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
that binds to IL-1 receptor type I, but does not elicit post-receptor signaling [7].
IL-1 Binding (binds) of
1) Confidence 0.47 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.70 Pain Relevance 0.34
Haplotype analysis revealed associations with IL1 locus.
IL1 Binding (associations) of
2) Confidence 0.47 Published 2008 Journal J. Rheumatol. Section Body Doc Link 18484691 Disease Relevance 0.05 Pain Relevance 0
Alpha(2)M binds various cytokines, including IL-1beta, as well as Abeta.
IL-1beta Binding (binds) of associated with abeta and cytokine
3) Confidence 0.47 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399113 Disease Relevance 0.74 Pain Relevance 0.49
PERSPECTIVE: This article shows evidence that genetic polymorphisms associated with IL-1beta high production genotype are implicated on the pathogenesis of BMS.
IL-1beta Binding (associated) of associated with burning mouth syndrome
4) Confidence 0.47 Published 2006 Journal J Pain Section Abstract Doc Link 16942951 Disease Relevance 0.79 Pain Relevance 0.26
In addition, the IL1RA VNTR polymorphism influences the plasma IL-1RA levels [13], and IL-1RA modulates IL-1 production [14], although there was no significant association of IL1B -31C>T and IL1RA VNTR with cerebral malaria in Gambia [5].
IL1B Neg (no) Binding (association) of in plasma associated with cerebral malaria
5) Confidence 0.37 Published 2005 Journal Malar J Section Body Doc Link PMC1224865 Disease Relevance 0.74 Pain Relevance 0
Clinically, the potential impact on the body's defense mechanisms resulting from the interaction between opioids, such as morphine, and cytokines, such as IL-1, can be substantial.
IL-1 Binding (interaction) of in body associated with opioid, cytokine and morphine
6) Confidence 0.37 Published 1998 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 9666258 Disease Relevance 0.18 Pain Relevance 0.83
Interleukin-1 interaction with neuroregulatory systems: selective enhancement by recombinant human and mouse interleukin-1 of in vitro opioid peptide receptor binding in rat brain.
Interleukin-1 Binding (interaction) of in brain associated with opioid
7) Confidence 0.37 Published 1989 Journal J. Neurosci. Res. Section Title Doc Link 2468786 Disease Relevance 0 Pain Relevance 0.36
The bioactivity of IL-1?
IL-1 Binding (bioactivity) of
8) Confidence 0.36 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.79 Pain Relevance 0.37
Polymorphisms in the IL-1 gene cluster associate with many clinical conditions, including inflammatory and infectious diseases (periodontal and arterial diseases, altered metabolic conditions, type 2 diabetes, type 2 diabetes complications, gastric cancer, rheumatoid arthritis, ankylosing spondylitis, systemic inflammation, myopathies, Alzheimer's disease, malaria, and bacterial vaginosis) [6,12,17,19,21,23-31].
IL-1 gene Binding (associate) of associated with spinal inflammation, diabetes mellitus, rheumatoid arthritis, disease, malaria, bacterial vaginosis, inflammation, diabetes complications, communicable diseases, muscle disease, artery disease and stomach cancer
9) Confidence 0.36 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 1.55 Pain Relevance 0.46
Recently, a study performed on 24 sedentary subjects (of unspecified ethnicity) selected on the basis of their haplotype pattern in the IL-1 gene cluster (based on specific combinations of +4845 IL-1A, +3954 IL-1B, -511 IL-1B, and -3737 IL-1B polymorphisms) showed that subjects C/C for IL-1B +3954 who carry allele 2 at IL-1RN +2018 were associated with the inflammation of skeletal muscle, following acute resistance exercise [10].
IL-1B Binding (associated) of in skeletal muscle associated with inflammation
10) Confidence 0.36 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 1.06 Pain Relevance 0.25
However, the final inflammatory activity of IL-1?
IL-1 Binding (activity) of associated with inflammation
11) Confidence 0.36 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.68 Pain Relevance 0.40
Therefore, our study provides evidence for an association between expression of COX-2 and IL-1beta, IL-6 and p65 in human CRC.
IL-1beta Binding (association) of associated with colon cancer
12) Confidence 0.36 Published 2003 Journal Carcinogenesis Section Abstract Doc Link 12727794 Disease Relevance 0.68 Pain Relevance 0.05
Recombinant human IL-1?
IL-1 Binding (Recombinant) of
13) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.06 Pain Relevance 0
After 24 hours of ligand treatment, IL-1?
IL-1 Binding (After) of
14) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
After 24 hours of incubation in DMEM/LH, IL-1?
IL-1 Binding (After) of
15) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
When we performed correlation analyses, we found that sCD154 was highly positively correlated with the pro-inflammatory cytokines IL1?
IL1 Binding (found) of associated with inflammation and cytokine
16) Confidence 0.36 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 0.30 Pain Relevance 0.28
Previously, we determined that simultaneous treatment with IL-1?
IL-1 Spec (determined) Binding (treatment) of
17) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.23 Pain Relevance 0.12
at the DR-1/AP-1 site at both promoters in cells treated with IL-1?
IL-1 Binding (treated) of
18) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
The figure also shows that treatment with IL-1?
IL-1 Binding (treatment) of
19) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
Our correlation analyses showed significant association between sCD154 and the pro-inflammatory markers IL6, IL1 ?
IL1 Binding (association) of associated with inflammatory marker
20) Confidence 0.36 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.26 Pain Relevance 0.65

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