INT64849

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 24
Total Number 29
Disease Relevance 14.36
Pain Relevance 9.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Ret)
Anatomy Link Frequency
neurons 5
spinal cord 3
hippocampus 3
sensory neurons 2
IB4 2
Ret (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 18 100.00 Very High Very High Very High
Nerve growth factor 7 100.00 Very High Very High Very High
Spinal cord 66 99.68 Very High Very High Very High
antidepressant 6 99.60 Very High Very High Very High
Root ganglion neuron 5 99.56 Very High Very High Very High
Calcitonin gene-related peptide 1 99.56 Very High Very High Very High
Hippocampus 15 99.48 Very High Very High Very High
dorsal root ganglion 25 99.30 Very High Very High Very High
Dorsal horn 16 99.20 Very High Very High Very High
fluoxetine 3 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperplasia 8 99.92 Very High Very High Very High
Injury 70 99.88 Very High Very High Very High
Nociception 39 99.84 Very High Very High Very High
Contusions 13 99.74 Very High Very High Very High
Ganglion Cysts 36 99.36 Very High Very High Very High
Parathyroid Cancer 2 99.32 Very High Very High Very High
Convulsion 34 99.22 Very High Very High Very High
Sprains And Strains 2 98.12 Very High Very High Very High
Thyroid Neoplasm 67 98.08 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 5 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A previously uncharacterized population of very small cells that express the receptor tyrosine kinase (RET) and that do not label for trkA or IB4-binding has the highest relative levels of VR1 mRNA.
Gene_expression (express) of RET in IB4 associated with vanilloid receptor subtype 1
1) Confidence 0.75 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10024368 Disease Relevance 0.32 Pain Relevance 1.28
Increased RET expression following peripheral axotomy was most pronounced in alpha-motoneurons.
Gene_expression (expression) of RET in motoneurons
2) Confidence 0.67 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17183535 Disease Relevance 0.32 Pain Relevance 0.42
In the ventral horn, RET-ir was strongly expressed by motoneurons, with the strongest staining in small, presumably gamma-motoneurons.
Gene_expression (expressed) of RET in ventral
3) Confidence 0.67 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17183535 Disease Relevance 0.31 Pain Relevance 0.43
The expression and regulation pattern of RET in the spinal cord are in line with its involvement in regenerative processes following nerve injury.
Gene_expression (expression) of RET in spinal cord associated with nervous system injury and spinal cord
4) Confidence 0.67 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17183535 Disease Relevance 0.34 Pain Relevance 0.42
The influence of both acute and chronic electroconvulsive seizure (ECS) or antidepressant drug treatments on expression of mRNAs encoding glial cell line-derived neurotrophic factor (GDNF) and its receptors, GFRalpha-1, GFRalpha-2, and c-Ret proto-oncogene (RET) in the rat hippocampus was examined by in situ hybridization.
Spec (examined) Gene_expression (expression) of RET in hippocampus associated with antidepressant, convulsion and hippocampus
5) Confidence 0.63 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.58 Pain Relevance 0.10
Developmental shift of vanilloid receptor 1 (VR1) terminals into deeper regions of the superficial dorsal horn: correlation with a shift from TrkA to Ret expression by dorsal root ganglion neurons.
Gene_expression (expression) of Ret in neurons associated with ganglion cysts, qutenza, root ganglion neuron and dorsal horn
6) Confidence 0.60 Published 2001 Journal Eur. J. Neurosci. Section Title Doc Link 11553280 Disease Relevance 0.48 Pain Relevance 0.75
OBJECTIVE: To investigate the expression of glial cell derived neurotrophic factor (GDNF) and its receptor GDNFR-alpha (GFRalpha-1) and GDNFR-beta (Ret) genes and the effects of muscarinic receptor antagonists, NMDA receptor antagonist, inhibitor of nitric oxide synthase on the expression of these genes in the spinal cord, brainstem and frontal cortex during morphine withdrawal, and to observe the effects of GDNF antisense oligoneucleotide (i.c.v) on the morphine withdrawal symptoms in rats.
Spec (investigate) Gene_expression (expression) of Ret in spinal cord associated with medulla, nmda receptor antagonist, antagonist, urological neuroanatomy, withdrawal, morphine and spinal cord
7) Confidence 0.58 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 11798749 Disease Relevance 0.26 Pain Relevance 0.65
We showed that ALK is specifically present in a subtype of neurons during DRG development, and that the majority of these neurons co-expressed TrkA and Ret.
Gene_expression (expressed) of Ret in neurons associated with dorsal root ganglion
8) Confidence 0.56 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19200234 Disease Relevance 0.85 Pain Relevance 0.31
Chronic (14 days) administration of different classes of antidepressant drugs, including tranylcypromine, desipramine, or fluoxetine, did not significantly affect the GDNF, GFRalpha-1, GFRalpha-2, or RET mRNA levels in CA1, CA3, and dentate gyrus areas of hippocampus.
Gene_expression (levels) of RET mRNA in hippocampus associated with desipramine, antidepressant, hippocampus and fluoxetine
9) Confidence 0.54 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.81 Pain Relevance 0.30
The influence of both acute and chronic electroconvulsive seizure (ECS) or antidepressant drug treatments on expression of mRNAs encoding glial cell line-derived neurotrophic factor (GDNF) and its receptors, GFRalpha-1, GFRalpha-2, and c-Ret proto-oncogene (RET) in the rat hippocampus was examined by in situ hybridization.
Spec (examined) Gene_expression (expression) of Ret in hippocampus associated with antidepressant, convulsion and hippocampus
10) Confidence 0.54 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.58 Pain Relevance 0.10
RET expression was unregulated following peripheral axotomy in alpha-motoneurons [38], and topical application of GDNF 30 min after SCI significantly improved motor function and reduced blood–spinal cord barrier (BSCB) breakdown, edema formation, and cell injury at 5 h has been reported [39].
Gene_expression (expression) of RET in spinal cord associated with pressure and volume under development, spinal cord injury, injury and spinal cord
11) Confidence 0.53 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.43 Pain Relevance 0.05
This ganglion is composed of heterogeneous sensory neurons characterized by the expression of RTK for neurotrophic factors, such as the nerve growth factor receptor TrkA or the glial-derived neurotrophic factor family receptor Ret, which are specifically detected in nociceptive neurons.
Gene_expression (expression) of Ret in sensory neurons associated with nociception, ganglion cysts and nerve growth factor
12) Confidence 0.48 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19200234 Disease Relevance 0.87 Pain Relevance 0.30
This ganglion is composed of heterogeneous sensory neurons characterized by the expression of RTK for neurotrophic factors, such as the nerve growth factor receptor TrkA or the glial-derived neurotrophic factor family receptor Ret, which are specifically detected in nociceptive neurons.
Gene_expression (detected) of Ret in sensory neurons associated with nociception, ganglion cysts and nerve growth factor
13) Confidence 0.48 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19200234 Disease Relevance 0.86 Pain Relevance 0.30
Nevertheless, in a recent study by Robledo et al [19], it has been clearly suggested that the presence of G91S/S904S polymorphisms of the RET is related to the early appearance of symptoms in MEN 2A patients, and therefore, these polymorphisms could be considered as genetic modifiers.
Gene_expression (polymorphisms) of RET associated with multiple endocrine neoplasia type 2a
14) Confidence 0.34 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC2164940 Disease Relevance 1.08 Pain Relevance 0
To confirm that the observed changes in gene expression in the transection model are an accurate portrayal of the TPS neuronal response to contusion injury, the expression of 8 different proteins (Gap43, Hspb1, Gfra1, Ret, Casp3, Ntrk1, Ntrk2, and Ntrk3) were examined immunofluorescently in DTMR retrogradely labeled TPS neurons following a moderate spinal contusion injury (NYU Impactor; 25 mm, 10 g weight drop).
Gene_expression (expression) of Ret in neuronal associated with injury and contusions
15) Confidence 0.27 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.87 Pain Relevance 0
OBJECTIVE: To investigate the expression of glial cell derived neurotrophic factor (GDNF) and its receptor GDNFR-alpha (GFRalpha-1) and GDNFR-beta (Ret) genes and the effects of muscarinic receptor antagonists, NMDA receptor antagonist, inhibitor of nitric oxide synthase on the expression of these genes in the spinal cord, brainstem and frontal cortex during morphine withdrawal, and to observe the effects of GDNF antisense oligoneucleotide (i.c.v) on the morphine withdrawal symptoms in rats.
Spec (investigate) Gene_expression (expression) of Ret in frontal cortex associated with medulla, nmda receptor antagonist, antagonist, urological neuroanatomy, withdrawal, morphine and spinal cord
16) Confidence 0.20 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 11798749 Disease Relevance 0.26 Pain Relevance 0.65
OBJECTIVE: To investigate the expression of glial cell derived neurotrophic factor (GDNF) and its receptor GDNFR-alpha (GFRalpha-1) and GDNFR-beta (Ret) genes and the effects of muscarinic receptor antagonists, NMDA receptor antagonist, inhibitor of nitric oxide synthase on the expression of these genes in the spinal cord, brainstem and frontal cortex during morphine withdrawal, and to observe the effects of GDNF antisense oligoneucleotide (i.c.v) on the morphine withdrawal symptoms in rats.
Spec (investigate) Gene_expression (expression) of Ret in brainstem associated with medulla, nmda receptor antagonist, antagonist, urological neuroanatomy, withdrawal, morphine and spinal cord
17) Confidence 0.20 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 11798749 Disease Relevance 0.26 Pain Relevance 0.65
Genetic analysis was carried out in both patients and a heterozygous M918T mutation of the RET proto-oncogene was found.
Gene_expression (found) of RET proto-oncogene
18) Confidence 0.15 Published 2008 Journal Eur. J. Pediatr. Section Abstract Doc Link 17576593 Disease Relevance 1.85 Pain Relevance 0.21
The receptor for GDNF is a complex of a ligand binding domain GFR1-3 and the signal transducing transmembrane protein, RET, and is expressed in a subgroup of non-peptidergic (IB4(+)) neurons [16].
Gene_expression (expressed) of RET in neurons
19) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0 Pain Relevance 0.03
Using immunohistochemical methods, we show that the majority of dorsal root ganglion cells that express GFRalpha3 also express vanilloid receptor type 1, peripherin, RET, trkA and calcitonin gene-related peptide.
Gene_expression (express) of RET in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and calcitonin gene-related peptide
20) Confidence 0.14 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11422460 Disease Relevance 0.27 Pain Relevance 0.30

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