INT64855

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Context Info
Confidence 0.68
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.29
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F8) oxidoreductase activity (F8) extracellular region (F8)
cell adhesion (F8)
Anatomy Link Frequency
blood 2
endothelium 2
F8 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 14 96.12 Very High Very High Very High
ischemia 5 88.40 High High
Inflammation 5 78.20 Quite High
anesthesia 8 76.64 Quite High
Central nervous system 1 72.64 Quite High
cytokine 2 72.56 Quite High
Pain 2 70.12 Quite High
Inflammatory response 2 69.88 Quite High
Versed 1 54.84 Quite High
antagonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombophilia 1 99.92 Very High Very High Very High
Thrombosis 25 98.76 Very High Very High Very High
Deep Vein Thrombosis 5 96.12 Very High Very High Very High
Disease 11 92.88 High High
Malignant Neoplastic Disease 6 92.24 High High
Cancer 4 90.88 High High
Cv Unclassified Under Development 5 88.40 High High
Pressure Volume 2 Under Development 33 87.28 High High
Coagulation Disorder 21 86.40 High High
Severe Combined Immunodeficiency 37 78.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pathogenesis remains under debate: the initial event would occur in the sinusoid endothelium creating a state of local hypercoagulability by release of tissue factors favoring deposit of coagulation factors, especially factor VIII, in the subendothelial region of the veinules.
Localization (release) of factor VIII in endothelium associated with thrombophilia
1) Confidence 0.68 Published 1997 Journal Ann Med Interne (Paris) Section Abstract Doc Link 9238437 Disease Relevance 0.65 Pain Relevance 0.11
Desmopressin (DDAVP) increases circulating levels of factor VIII:C by stimulating the release of factor VIII:C from peripheral storage sites.
Localization (release) of factor VIII
2) Confidence 0.63 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8831325 Disease Relevance 0.08 Pain Relevance 0.08
Interrogation of other factors along the coagulation cascade that are triggered by Factor VIII, such as Factor Xa and thrombin, suggests that thrombin, which is the terminal enzyme of the hemostatic system, is likely to be the actual mediator of this novel checkpoint of organ size control.
Localization (triggered) of Factor VIII
3) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.08 Pain Relevance 0
In conclusion, blood type O patients showed decreased factor VIII and increased aPTT compared to the non-O patients from the beginning, and transient further deterioration shortly after 15 ml/kg of Voluven infusion.
Localization (decreased) of factor VIII in blood
4) Confidence 0.20 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2876854 Disease Relevance 0.90 Pain Relevance 0.16
From this result, we assumed that the decrease of factor VIII by 15 ml/kg of HES is mainly due to hemodilution and not related to the inhibition of factor VIII out of proportion by O blood type.
Localization (decrease) of factor VIII in blood
5) Confidence 0.20 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2876854 Disease Relevance 0.22 Pain Relevance 0
These include the continuous release of blood coagulation tissue factor, changes in the composition of the haemostatic parameters (elevated fibrinogen, Factor VIII, and the PAI-Level) and damage to the endothelium [10].
Localization (release) of Factor VIII in endothelium
6) Confidence 0.10 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703234 Disease Relevance 1.36 Pain Relevance 0.16

General Comments

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