INT6486

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 9
Speculated 2
Reported most in Abstract
Documents 168
Total Number 171
Disease Relevance 123.47
Pain Relevance 66.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
liver 7
plasma 6
macrophages 5
neutrophil 5
lung 5
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 678 100.00 Very High Very High Very High
cytokine 357 100.00 Very High Very High Very High
Spinal cord 104 100.00 Very High Very High Very High
Inflammatory mediators 21 100.00 Very High Very High Very High
neuralgia 4 100.00 Very High Very High Very High
Morphine 49 99.98 Very High Very High Very High
Neuropathic pain 25 99.92 Very High Very High Very High
Paracetamol 329 99.84 Very High Very High Very High
chemokine 96 99.84 Very High Very High Very High
narcan 22 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 710 100.00 Very High Very High Very High
Cancer 425 100.00 Very High Very High Very High
Disease 194 100.00 Very High Very High Very High
Necrosis 168 100.00 Very High Very High Very High
Urological Neuroanatomy 45 100.00 Very High Very High Very High
Inflammatory Bowel Disease 27 100.00 Very High Very High Very High
Obesity 190 99.98 Very High Very High Very High
Frailty 34 99.98 Very High Very High Very High
Infection 88 99.96 Very High Very High Very High
Neuropathic Pain 52 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings provide evidence that presynaptic alterations caused by peripheral inflammation is partly attributable to the up-regulation of TNF-alpha in the ACC.
Positive_regulation (up-regulation) of TNF-alpha in ACC associated with inflammation and anterior cingulate cortex
1) Confidence 0.70 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17222972 Disease Relevance 0.62 Pain Relevance 0.76
Prostaglandin E(2) (PGE(2)) and tumor necrosis factor alpha (TNF-alpha) levels were increased 96 h post-UVB in acutely irradiated animals and both mediators were modified by topical naproxen application-PGE(2) was decreased while TNF-alpha was increased.
Positive_regulation (increased) of tumor necrosis factor alpha associated with necrosis and cancer
2) Confidence 0.70 Published 2010 Journal Photochem. Photobiol. Section Abstract Doc Link 19845543 Disease Relevance 0.77 Pain Relevance 0.18
Prostaglandin E(2) (PGE(2)) and tumor necrosis factor alpha (TNF-alpha) levels were increased 96 h post-UVB in acutely irradiated animals and both mediators were modified by topical naproxen application-PGE(2) was decreased while TNF-alpha was increased.
Positive_regulation (increased) of TNF-alpha associated with necrosis and cancer
3) Confidence 0.70 Published 2010 Journal Photochem. Photobiol. Section Abstract Doc Link 19845543 Disease Relevance 0.76 Pain Relevance 0.18
Furthermore, reduction in the incidence of tumor lesions by naproxen may be due to its ability to increase TNF-alpha levels as well as to decrease PGE(2).
Positive_regulation (increase) of TNF-alpha associated with cancer
4) Confidence 0.70 Published 2010 Journal Photochem. Photobiol. Section Abstract Doc Link 19845543 Disease Relevance 0.76 Pain Relevance 0.13
Prostaglandin E(2) (PGE(2)) and tumor necrosis factor alpha (TNF-alpha) levels were increased 96 h post-UVB in acutely irradiated animals and both mediators were modified by topical naproxen application-PGE(2) was decreased while TNF-alpha was increased.
Positive_regulation (increased) of TNF-alpha associated with necrosis and cancer
5) Confidence 0.70 Published 2010 Journal Photochem. Photobiol. Section Abstract Doc Link 19845543 Disease Relevance 0.77 Pain Relevance 0.18
Mice challenged with LPS or BA for 19 days showed significant increase in the immobility time and hyperalgesia on day 19, as well as marked increase in serum tumor necrosis factor-alpha (TNF-alpha) levels.
Positive_regulation (increase) of tumor necrosis factor-alpha associated with necrosis, hyperalgesia, cancer and brucella infection
6) Confidence 0.70 Published 2009 Journal Immunobiology Section Abstract Doc Link 19159825 Disease Relevance 1.53 Pain Relevance 0.19
Mice challenged with LPS or BA for 19 days showed significant increase in the immobility time and hyperalgesia on day 19, as well as marked increase in serum tumor necrosis factor-alpha (TNF-alpha) levels.
Positive_regulation (increase) of TNF-alpha associated with necrosis, hyperalgesia, cancer and brucella infection
7) Confidence 0.70 Published 2009 Journal Immunobiology Section Abstract Doc Link 19159825 Disease Relevance 1.54 Pain Relevance 0.19
Animals that developed pain behaviors had increased levels of TNF-alpha mRNA in the brain.
Positive_regulation (increased) of TNF-alpha mRNA in brain associated with pain
8) Confidence 0.70 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17416966 Disease Relevance 1.12 Pain Relevance 0.35
TNF-alpha mRNA levels in the brain were elevated at 12 and 24 h, with elevated protein levels at 6 h.
Positive_regulation (elevated) of TNF-alpha mRNA in brain
9) Confidence 0.70 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17416966 Disease Relevance 1.13 Pain Relevance 0.34
TNF-alpha mRNA in the cord was increased at 3, 6, 12, and 24 h in QUIS-injected animals relative to shams.
Positive_regulation (increased) of TNF-alpha mRNA
10) Confidence 0.70 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17416966 Disease Relevance 1.13 Pain Relevance 0.28
TNF-alpha protein was elevated at 12 and 48 h postinjury.
Positive_regulation (elevated) of TNF-alpha
11) Confidence 0.70 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17416966 Disease Relevance 1.13 Pain Relevance 0.34
Observations suggest that TNFalpha and IL-1alpha are the first cytokines with protein production that is upregulated during rapid-WD.
Positive_regulation (upregulated) of TNFalpha associated with wallerian degeneration and cytokine
12) Confidence 0.70 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.60 Pain Relevance 0.37
CONCLUSIONS: These results suggest that TNF-alpha inhibits MOR-induced rewarding effect and sensitization by regulating extracellular dopamine levels, and Leu-Ile inhibits them via the induction of TNF-alpha.


Positive_regulation (induction) of TNF-alpha
13) Confidence 0.70 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 17217924 Disease Relevance 0 Pain Relevance 0
In contrast, TNF-alpha activity significantly increased in response to MHV3, reaching 16.3 +/- 5.5 U/ml from 24 h post infection (P less than 0.01).
Positive_regulation (increased) of TNF-alpha associated with coronavirus infection and infection
14) Confidence 0.69 Published 1992 Journal Liver Section Abstract Doc Link 1328801 Disease Relevance 1.33 Pain Relevance 0.33
In conclusion, our study further supports the implication of TNF-alpha in virus-induced hepatitis failure and confirms that paracetamol poisoning does not cause increased TNF-alpha activity in the circulation.
Neg (not) Positive_regulation (cause) of TNF-alpha associated with paracetamol, poisoning and hepatitis
15) Confidence 0.69 Published 1992 Journal Liver Section Abstract Doc Link 1328801 Disease Relevance 1.33 Pain Relevance 0.33
No elevation of TNF-alpha activity was found in hepatic failure complicating paracetamol poisoning.
Neg (No) Positive_regulation (elevation) of TNF-alpha associated with liver failure, paracetamol and poisoning
16) Confidence 0.69 Published 1992 Journal Liver Section Abstract Doc Link 1328801 Disease Relevance 1.33 Pain Relevance 0.33
Morphine withdrawal sensitizes mice to lipopolysaccharide: elevated TNF-alpha and nitric oxide with decreased IL-12.
Positive_regulation (elevated) of TNF-alpha associated with withdrawal and morphine
17) Confidence 0.69 Published 2005 Journal J. Neuroimmunol. Section Title Doc Link 15913793 Disease Relevance 0 Pain Relevance 0.70
There was a significant increase in serum TNFalpha at 6 h (control 0.002+/-0.002 ng/ml, n=7; paracetamol-treated 0.022+/-0.007 ng/ml, n=5, p<0.05), but hepatic TNFalpha expression did not change up to 24 h following paracetamol injection.
Positive_regulation (increase) of TNFalpha associated with paracetamol
18) Confidence 0.69 Published 2000 Journal J. Pathol. Section Abstract Doc Link 10700000 Disease Relevance 0.95 Pain Relevance 0.72
Previously, we demonstrated that glutamate and tumor necrosis factor alpha (TNFalpha) kill neurons via activation of the N-methyl-d-aspartate (NMDA) and TNFalpha receptors, respectively.
Positive_regulation (activation) of TNFalpha in neurons associated with necrosis, glutamate and cancer
19) Confidence 0.68 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17241124 Disease Relevance 0.70 Pain Relevance 0.41
TNF-alpha and TNF-alpha receptor type 1 upregulation in glia and neurons after peripheral nerve injury: studies in murine DRG and spinal cord.
Positive_regulation (upregulation) of TNF-alpha in neurons associated with neuralgia, nervous system injury, spinal cord and peripheral nerve injury
20) Confidence 0.67 Published 2004 Journal Spine Section Title Doc Link 15131433 Disease Relevance 0.62 Pain Relevance 0.44

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