INT64862

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Context Info
Confidence 0.36
First Reported 1996
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.76
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
PTGS2 (Homo sapiens)
PTGS2 - R106E (1)
Pain Link Frequency Relevance Heat
Potency 6 100.00 Very High Very High Very High
COX2 2 100.00 Very High Very High Very High
cINOD 14 91.96 High High
Osteoarthritis 1 86.84 High High
diclofenac 1 85.28 High High
Analgesic 1 39.72 Quite Low
Inflammation 1 38.60 Quite Low
Disease Link Frequency Relevance Heat
Infertility 3 99.92 Very High Very High Very High
INFLAMMATION 6 99.34 Very High Very High Very High
Cleidocranial Dysplasia 1 87.92 High High
Hip Osteoarthritis 1 86.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nonsteroidal antiinflammatory drugs may induce infertility by reducing the production of prostaglandins, most notably via inhibition of the enzyme cyclooxygenase 2.
Negative_regulation (reducing) of Negative_regulation (inhibition) of cyclooxygenase 2 associated with inflammation, infertility and cox2
1) Confidence 0.36 Published 1999 Journal Rev Rhum Engl Ed Section Abstract Doc Link 10327496 Disease Relevance 0.64 Pain Relevance 0.17
The greatest loss of potency for inhibition of hPGHS-2(R106E) was observed with the hPGHS-2-selective sulfonamide-containing inhibitors NS-398 and flosulide.
Negative_regulation (loss) of Negative_regulation (inhibition) of hPGHS-2 (R106E) associated with potency
2) Confidence 0.27 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9351974 Disease Relevance 0.07 Pain Relevance 0.61
In contrast, the selective PGHS-2 inhibitor NS-398 exhibited time-independent inhibition of hPGHS-1 but time-dependent inhibition of hPGHS-2 in intact cells.
Negative_regulation (exhibited) of Negative_regulation (inhibition) of hPGHS-2
3) Confidence 0.18 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8831731 Disease Relevance 0.05 Pain Relevance 0.31

General Comments

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