INT64864

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Context Info
Confidence 0.77
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 10.45
Pain Relevance 4.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLA2G4A) aging (PLA2G4A) Golgi apparatus (PLA2G4A)
endoplasmic reticulum (PLA2G4A) cytoplasmic membrane-bounded vesicle (PLA2G4A) nucleus (PLA2G4A)
Anatomy Link Frequency
fibroblasts 3
monocytes 1
brain 1
platelet 1
PLA2G4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 305 99.98 Very High Very High Very High
ischemia 1 98.36 Very High Very High Very High
cINOD 44 98.24 Very High Very High Very High
COX2 10 98.04 Very High Very High Very High
rheumatoid arthritis 91 95.04 Very High Very High Very High
fibrosis 8 92.00 High High
chemokine 13 91.76 High High
cytokine 95 87.68 High High
backache 2 86.68 High High
Sciatica 2 85.80 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 333 99.98 Very High Very High Very High
Colon Cancer 12 99.78 Very High Very High Very High
Pancreatic Cancer 9 99.38 Very High Very High Very High
Cv General 4 Under Development 1 98.72 Very High Very High Very High
Prolapse 4 98.64 Very High Very High Very High
Injury 5 97.84 Very High Very High Very High
Epilepsy 1 97.52 Very High Very High Very High
Disease 118 97.00 Very High Very High Very High
Adenocarcinoma 6 96.12 Very High Very High Very High
Osteoarthritis 5 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paradoxically, GCs are reported to stimulate cytosolic phosphoplipase A2 group IVA (PLA2G4A) and prostaglandin-endoperoxide synthase 2 (PTGS2) expression in human amnion fibroblasts.
Gene_expression (expression) of phosphoplipase A2 group IVA in fibroblasts
1) Confidence 0.77 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.10 Pain Relevance 0.16
Paradoxically, GCs are reported to stimulate cytosolic phosphoplipase A2 group IVA (PLA2G4A) and prostaglandin-endoperoxide synthase 2 (PTGS2) expression in human amnion fibroblasts.
Gene_expression (expression) of PLA2G4A in fibroblasts
2) Confidence 0.77 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.09 Pain Relevance 0.16
This study was designed to examine the molecular mechanisms underlying glucocorticoid-induced PLA2G4A expression in human amnion fibroblasts.
Gene_expression (expression) of PLA2G4A in fibroblasts
3) Confidence 0.77 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.20 Pain Relevance 0.16
Ellagic acid suppressed the lipopolysaccharide-induced increase in protein expression of cyclo-oxygenase-2 (COX-2), microsomal PGE synthase-1 (mPGEs-1) and cytosolic phospholipase A2alpha (cPLA2alpha), while it had no effect on the constitutively expressed COX-1 protein.
Gene_expression (expression) of cPLA2alpha
4) Confidence 0.75 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.57 Pain Relevance 0.21
We conclude that the inhibitory effect of ellagic acid on PGE2 release from monocytes is due to a suppressed expression of COX-2, mPGEs-1 and cPLA2alpha, rather than a direct effect on the activities of these enzymes.
Gene_expression (expression) of cPLA2alpha in monocytes
5) Confidence 0.75 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.45 Pain Relevance 0.16
Production of the COX product, prostaglandin E2, correlated with expression of cPLA2 and COX-2 and was blocked by non-steroidal anti-inflammatory drugs (NSAIDs, indomethacin or NS398).
Gene_expression (expression) of cPLA2 associated with inflammation and cinod
6) Confidence 0.71 Published 2004 Journal Cancer Biol. Ther. Section Abstract Doc Link 15477758 Disease Relevance 0.59 Pain Relevance 0.23
COX-1 expression was constitutive in 9/9 pancreatic cancer cell lines, whereas COX-2 and cytosolic phospholipase A2 (cPLA2) expression were observed in 4/9 cell lines (BxPC3, Capan2, Cfpac1, and L3.6 pl).
Gene_expression (expression) of cPLA2 associated with pancreatic cancer
7) Confidence 0.71 Published 2004 Journal Cancer Biol. Ther. Section Abstract Doc Link 15477758 Disease Relevance 0.59 Pain Relevance 0.21
COX-1 expression was constitutive in 9/9 pancreatic cancer cell lines, whereas COX-2 and cytosolic phospholipase A2 (cPLA2) expression were observed in 4/9 cell lines (BxPC3, Capan2, Cfpac1, and L3.6 pl).
Gene_expression (expression) of cytosolic phospholipase A2 associated with pancreatic cancer
8) Confidence 0.71 Published 2004 Journal Cancer Biol. Ther. Section Abstract Doc Link 15477758 Disease Relevance 0.59 Pain Relevance 0.21
In this situation, cPLA2 was readily detected in COX-2- and Nuc-containing fractions (Fig. 2C).


Gene_expression (detected) of cPLA2
9) Confidence 0.64 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373884 Disease Relevance 0 Pain Relevance 0
Fifty-three disc prolapses obtained at disc operations were analyzed by immunohistochemistry, using anti-human monoclonal antibodies to sPLA2 and cPLA2, respectively.
Spec (analyzed) Gene_expression (using) of cPLA2 associated with prolapse
10) Confidence 0.62 Published 1998 Journal Eur Spine J Section Abstract Doc Link 9840472 Disease Relevance 0.60 Pain Relevance 0.17
The results showed that sPLA2 was more common (25/53, 47%) than cPLA2 (13/53, 25%). sPLA2 and cPLA2 were simultaneously present in 13 of 53 samples (25%).
Gene_expression (present) of cPLA2
11) Confidence 0.62 Published 1998 Journal Eur Spine J Section Abstract Doc Link 9840472 Disease Relevance 0.57 Pain Relevance 0.18
The Group IVA cytosolic phospholipase A2 (GIVA cPLA2) is a key provider of substrates for the production of eicosanoids and platelet-activating factor.
Gene_expression (production) of cPLA2 in platelet
12) Confidence 0.61 Published 2007 Journal J. Med. Chem. Section Abstract Doc Link 17672443 Disease Relevance 0 Pain Relevance 0
Expression of the inducible oxidoreductase cyclooxygenase-2 and cytosolic phospholipase A2 (cPLA2) are strongly activated during cerebral ischemia and trauma, epilepsy and AD, indicating the induction of proinflammatory gene pathways as a response to brain injury.
Gene_expression (Expression) of cPLA2 in brain associated with epilepsy, cv general 4 under development, ischemia, injury, disease and brain injury
13) Confidence 0.53 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11059791 Disease Relevance 1.42 Pain Relevance 0.25
Primary EM cultures from all 10 donors expressed cPLA2, COX-1, cPGES, mPGES-1 and mPGES-2 proteins (Figure 2A).
Gene_expression (expressed) of cPLA2
14) Confidence 0.34 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0 Pain Relevance 0.03
It has been shown that cPLA2 overexpression significantly increased the PPAR-?
Gene_expression (overexpression) of cPLA2
15) Confidence 0.32 Published 2005 Journal Respir Res Section Body Doc Link PMC1242255 Disease Relevance 1.12 Pain Relevance 0.12
An analysis of eight colorectal cancer cell lines and 65 colorectal cancers showed an overexpression of cPLA2 in about 50% of the cases which correlated with COX2 expression in a positive manner [72].
Gene_expression (overexpression) of cPLA2 associated with colon cancer and cox2
16) Confidence 0.22 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.76 Pain Relevance 0.32
Pro-inflammatory, as well as anti-inflammatory properties of cPLA2?
Gene_expression (properties) of cPLA2 associated with inflammation
17) Confidence 0.16 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.89 Pain Relevance 0.38
IL-4 also decreases the mRNA production of cyclo-oxygenase 2 and cytosolic phospholipase A2, thereby reducing the levels of prostaglandin E2 [90,91].
Gene_expression (production) of cytosolic phospholipase A2
18) Confidence 0.14 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.82 Pain Relevance 0.58
However, differences were observed in the ability of the hPGHS isoforms to utilize endogenous arachidonic acid released intracellularly following calcium ionophore stimulation or released by human cytosolic phospholipase A2 transiently expressed in the cells.
Gene_expression (expressed) of cytosolic phospholipase
19) Confidence 0.11 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8831731 Disease Relevance 0.14 Pain Relevance 0.36
As shown in table 5, the gene encoding the upstream cytosolic phospholipase PLA2G4A, which is the initial rate-limiting enzyme that cleaves membrane phospholipids [78], is over-expressed.
Gene_expression (expressed) of phospholipase PLA2G4A
20) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 0.95 Pain Relevance 0.20

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