INT6487

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Context Info
Confidence 0.56
First Reported 1992
Last Reported 2010
Negated 6
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 16.06
Pain Relevance 5.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
neutrophil 6
microglia 4
peritoneal macrophages 4
plasma 2
cavities 2
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 13 100.00 Very High Very High Very High
Inflammatory mediators 2 100.00 Very High Very High Very High
Neuropathic pain 5 99.92 Very High Very High Very High
Thermal hyperalgesia 5 99.76 Very High Very High Very High
Inflammation 84 99.48 Very High Very High Very High
alcohol 4 99.00 Very High Very High Very High
Brush evoked pain 6 98.76 Very High Very High Very High
Locus ceruleus 1 97.96 Very High Very High Very High
cytokine 49 97.68 Very High Very High Very High
Central nervous system 30 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 230 100.00 Very High Very High Very High
INFLAMMATION 94 100.00 Very High Very High Very High
Necrosis 21 100.00 Very High Very High Very High
Hepatotoxicity 7 100.00 Very High Very High Very High
Asthma 30 99.92 Very High Very High Very High
Neuropathic Pain 11 99.92 Very High Very High Very High
Nociception 12 99.80 Very High Very High Very High
Poisoning 2 99.80 Very High Very High Very High
Hyperalgesia 8 99.76 Very High Very High Very High
Obesity 168 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Inflammatory models of cystitis result in increased levels of TNF-alpha, SP and NGF production in the bladder, paralleling the hypothesized neuro-inflammatory etiology of IC.
Positive_regulation (result) of Positive_regulation (increased) of TNF-alpha in bladder
1) Confidence 0.56 Published 2005 Journal J. Urol. Section Body Doc Link 15643278 Disease Relevance 0.11 Pain Relevance 0
Accumulation of TNFalpha is increased initially in a region of the brain containing the locus coeruleus (LC) at day 4 post-ligature placement, followed by an increase in TNFalpha in the hippocampus at day 8 post-ligature placement, coincident with hyperalgesia.
Positive_regulation (increased) of Positive_regulation (Accumulation) of TNFalpha in locus coeruleus associated with hyperalgesia, locus ceruleus and hippocampus
2) Confidence 0.52 Published 2000 Journal Brain Res. Section Abstract Doc Link 10720620 Disease Relevance 0.87 Pain Relevance 0.88
We observed that PDT treatment of antigen positive CT26.CL25 (but not antigen-negative CT26WT) tumors led to striking and significant (p<0.001) increases in tumor necrosis factor alpha (TNF?)
Positive_regulation (led) of Positive_regulation (increases) of tumor necrosis factor alpha associated with necrosis and cancer
3) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001867 Disease Relevance 1.25 Pain Relevance 0.09
This suggestion is supported by the following observations: (a) pretreatment of the peritoneal cavities with antisera against these cytokines reduced the nociceptive responses induced by these stimuli; (b) peritoneal cells harvested from cavities injected with zymosan or acetic acid released both interleukin 1beta and TNF-alpha; (c) although individual injection of TNF-alpha, interleukin 1beta or interleukin 8 did not induce the nociceptive effect, intraperitoneal injection of a mixture of these three recombinant cytokines caused a significant nociceptive writhing response.
Neg (not) Positive_regulation (induce) of Positive_regulation (injection) of TNF-alpha in cavities associated with nociception and cytokine
4) Confidence 0.49 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10633169 Disease Relevance 0.89 Pain Relevance 0.10
CONCLUSIONS: These data demonstrate that upregulation of glial TNF-alpha is associated with the expression of the p55 receptor on adjacent neurons.
Positive_regulation (associated) of Positive_regulation (upregulation) of TNF-alpha in neurons
5) Confidence 0.49 Published 2004 Journal Spine Section Body Doc Link 15131433 Disease Relevance 0.06 Pain Relevance 0
The levels of Tumour Necrosis Factor (TNF)alpha and NGF were upregulated at 1.5 h whereas those of IL-1beta at 6 h after ET injection.
Positive_regulation (upregulated) of Positive_regulation (upregulated) of TNF associated with necrosis and cancer
6) Confidence 0.49 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9663559 Disease Relevance 0.46 Pain Relevance 0.29
Obese subjects have elevated inflammatory mediators, namely IL-6, IL-8, and TNF-?
Positive_regulation (elevated) of Positive_regulation (elevated) of TNF associated with inflammatory mediators and obesity
7) Confidence 0.49 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 1.97 Pain Relevance 0.17
Moreover, gasless suspension and pneumoperitoneum did not lead to an increase in tumor necrosis factor alpha or nitric oxide production by peritoneal macrophages.
Neg (not) Positive_regulation (lead) of Positive_regulation (increase) of tumor necrosis factor alpha in peritoneal macrophages
8) Confidence 0.47 Published 1997 Journal J. Am. Coll. Surg. Section Body Doc Link 9100680 Disease Relevance 0 Pain Relevance 0
In conclusion, our study further supports the implication of TNF-alpha in virus-induced hepatitis failure and confirms that paracetamol poisoning does not cause increased TNF-alpha activity in the circulation.
Neg (not) Positive_regulation (cause) of Positive_regulation (increased) of TNF-alpha associated with paracetamol, poisoning and hepatitis
9) Confidence 0.47 Published 1992 Journal Liver Section Abstract Doc Link 1328801 Disease Relevance 1.33 Pain Relevance 0.33
In addition, TNF-alpha production was increased by ip DADL (1.0 mg.kg-1 x 6 d) in mice and the production of LPS-induced TNF-alpha in mouse peritoneal macrophages was enhanced after DADL was added in vitro.
Positive_regulation (enhanced) of Positive_regulation (induced) of TNF-alpha in peritoneal macrophages
10) Confidence 0.45 Published 1995 Journal Yao Xue Xue Bao Section Abstract Doc Link 7785437 Disease Relevance 0 Pain Relevance 0.18
PSL-induced upregulation of tumor necrosis factor-alpha and interleukin-6, which are essential for neuropathic pain, was suppressed by pioglitazone for the first week.
Positive_regulation (induced) of Positive_regulation (upregulation) of tumor necrosis factor-alpha associated with necrosis, cancer and neuropathic pain
11) Confidence 0.44 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19008646 Disease Relevance 1.55 Pain Relevance 1.56
RESULTS: LPS induced significant increases in TNFalpha and MIP-2 production.
Positive_regulation (induced) of Positive_regulation (increases) of TNFalpha
12) Confidence 0.43 Published 2005 Journal J. Surg. Res. Section Body Doc Link 15921696 Disease Relevance 0 Pain Relevance 0
Exposure to LPS increased the levels of TNF-alpha, SP and NGF production compared with controls (each p <0.05).
Positive_regulation (increased) of Positive_regulation (increased) of TNF-alpha
13) Confidence 0.41 Published 2005 Journal J. Urol. Section Body Doc Link 15643278 Disease Relevance 0.15 Pain Relevance 0
Increased levels of TNF-alpha were found in the bronchoalveolar lavage fluid of mice undergoing a dinitrofluorobenzene (DNFB)-induced non-IgE-mediated pulmonary hypersensitivity reaction.
Positive_regulation (levels) of Positive_regulation (Increased) of TNF-alpha associated with hypersensitivity
14) Confidence 0.40 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11994487 Disease Relevance 0.47 Pain Relevance 0.18
Increased levels of TNF-alpha were found in the bronchoalveolar lavage fluid of mice undergoing a dinitrofluorobenzene (DNFB)-induced non-IgE-mediated pulmonary hypersensitivity reaction.
Positive_regulation (Increased) of Positive_regulation (levels) of TNF-alpha associated with hypersensitivity
15) Confidence 0.40 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11994487 Disease Relevance 0.47 Pain Relevance 0.18
In contrast, alcohol pretreatment of C3H/HeJ mice caused little to no increase in APAP hepatotoxicity and no increase in plasma TNF-alpha.
Neg (no) Positive_regulation (increase) of Neg (no) Positive_regulation (increase) of TNF-alpha in plasma associated with paracetamol, hepatotoxicity and alcohol
16) Confidence 0.35 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16439473 Disease Relevance 0.52 Pain Relevance 0.71
As critical mediators of inflammation, activated microglia and elevated levels of tumor necrosis factor-alpha (TNF-?)
Positive_regulation (levels) of Positive_regulation (elevated) of tumor necrosis factor-alpha in microglia associated with necrosis, inflammation and cancer
17) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 2.21 Pain Relevance 0.20
As critical mediators of inflammation, activated microglia and elevated levels of tumor necrosis factor-alpha (TNF-?)
Positive_regulation (elevated) of Positive_regulation (levels) of tumor necrosis factor-alpha in microglia associated with necrosis, inflammation and cancer
18) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2974667 Disease Relevance 2.21 Pain Relevance 0.20
The pattern of chemokine expression is consistent with the delay in neutrophil recruitment to the footpad: T. maculosa venom stimulated an early production of IL-1beta, IL-6, and MCP-1, but was unable to induce an effective early TNF-alpha and KC release.
Neg (unable) Positive_regulation (induce) of Positive_regulation (effective) of TNF-alpha in neutrophil associated with chemokine
19) Confidence 0.18 Published 2008 Journal Toxicon Section Abstract Doc Link 18586048 Disease Relevance 0.51 Pain Relevance 0.20
The pattern of chemokine expression is consistent with the delay in neutrophil recruitment to the footpad: T. maculosa venom stimulated an early production of IL-1beta, IL-6, and MCP-1, but was unable to induce an effective early TNF-alpha and KC release.
Positive_regulation (effective) of Positive_regulation (early) of TNF-alpha in neutrophil associated with chemokine
20) Confidence 0.18 Published 2008 Journal Toxicon Section Abstract Doc Link 18586048 Disease Relevance 0.51 Pain Relevance 0.20

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