INT6488

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2011
Negated 7
Speculated 13
Reported most in Abstract
Documents 484
Total Number 498
Disease Relevance 339.61
Pain Relevance 191.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
macrophages 56
liver 16
monocytes 13
blood 10
T-cell 10
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2078 100.00 Very High Very High Very High
cytokine 1563 100.00 Very High Very High Very High
Paracetamol 408 100.00 Very High Very High Very High
Pain 278 100.00 Very High Very High Very High
chemokine 276 100.00 Very High Very High Very High
Inflammatory response 206 100.00 Very High Very High Very High
metalloproteinase 180 100.00 Very High Very High Very High
Inflammatory mediators 78 100.00 Very High Very High Very High
Glutamate 50 100.00 Very High Very High Very High
methotrexate 34 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2371 100.00 Very High Very High Very High
Disease 1191 100.00 Very High Very High Very High
Cancer 595 100.00 Very High Very High Very High
Necrosis 465 100.00 Very High Very High Very High
Obesity 461 100.00 Very High Very High Very High
Apoptosis 300 100.00 Very High Very High Very High
Adhesions 184 100.00 Very High Very High Very High
Sepsis 92 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 22 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 16 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is not known if TNF-alpha expression is altered in the ACC in response to persistent pain and if synaptic transmission within this region is modulated by TNF-alpha.
Gene_expression (expression) of TNF-alpha in ACC associated with pain, lasting pain and anterior cingulate cortex
1) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17222972 Disease Relevance 0.76 Pain Relevance 0.77
In the present study, we examined TNF-alpha expression in the mouse ACC following hind-paw administration of complete Freund's adjuvant (CFA) and examined the role of TNF-alpha in ACC synaptic transmission.
Spec (examined) Gene_expression (expression) of TNF-alpha in ACC associated with anterior cingulate cortex
2) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17222972 Disease Relevance 0.73 Pain Relevance 0.82
Moreover, gasless suspension and pneumoperitoneum did not lead to an increase in tumor necrosis factor alpha or nitric oxide production by peritoneal macrophages.
Gene_expression (production) of tumor necrosis factor alpha in peritoneal macrophages
3) Confidence 0.78 Published 1997 Journal J. Am. Coll. Surg. Section Body Doc Link 9100680 Disease Relevance 0 Pain Relevance 0
Last, as a marker of postoperative stress, the in vitro production of nitric oxide and tumor necrosis factor alpha by these macrophages was determined.
Spec (determined) Gene_expression (production) of tumor necrosis factor alpha in macrophages
4) Confidence 0.78 Published 1997 Journal J. Am. Coll. Surg. Section Body Doc Link 9100680 Disease Relevance 0 Pain Relevance 0
In addition, macrophage production of tumor necrosis factor alpha and nitric oxide, two markers of macrophage stress, 24 hours after operation was significantly increased in the laparotomy group compared with animals serving as controls.
Gene_expression (production) of tumor necrosis factor alpha in macrophage
5) Confidence 0.78 Published 1997 Journal J. Am. Coll. Surg. Section Body Doc Link 9100680 Disease Relevance 0 Pain Relevance 0
Moreover, TNF-alpha production was significantly reduced.
Gene_expression (production) of TNF-alpha
6) Confidence 0.78 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10337911 Disease Relevance 0.52 Pain Relevance 0.19
The aim of our study was to clarify the effect of morphine on lipopolysaccharide (LPS)-induced TNF-alpha production in vivo.
Gene_expression (production) of TNF-alpha associated with morphine
7) Confidence 0.78 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058753 Disease Relevance 0.39 Pain Relevance 0.57
Blockade of the sympathetic transmission by chlorisondamine prevented the inhibitory effect of morphine on TNF-alpha production.
Gene_expression (production) of TNF-alpha in sympathetic associated with morphine
8) Confidence 0.78 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058753 Disease Relevance 0.39 Pain Relevance 0.76
Morphine treatment modulates a variety of immunological parameters, including tumor necrosis factor-alpha (TNF-alpha) production by activated macrophages in vitro.
Gene_expression (production) of TNF-alpha in macrophages associated with necrosis, cancer and morphine
9) Confidence 0.78 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058753 Disease Relevance 0.35 Pain Relevance 0.50
Subcutaneous injection of morphine decreased LPS-induced TNF-alpha production throughout the response, an effect that was dose-dependent and reversible by naloxone.
Gene_expression (production) of TNF-alpha associated with narcan and morphine
10) Confidence 0.78 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058753 Disease Relevance 0.39 Pain Relevance 0.72
Effect of morphine on lipopolysaccharide-induced tumor necrosis factor-alpha production in vivo: involvement of the sympathetic nervous system.
Gene_expression (production) of tumor necrosis factor-alpha in sympathetic nervous system associated with necrosis, cancer, narcan and morphine
11) Confidence 0.78 Published 1997 Journal J. Neuroimmunol. Section Title Doc Link 9058753 Disease Relevance 0.45 Pain Relevance 0.75
It is concluded that (i) systemic administration of morphine inhibits LPS-induced TNF-alpha production in vivo via 'classic' opioid receptors; (ii) this effect requires intact sympathetic outflow.
Gene_expression (production) of TNF-alpha in outflow associated with opioid receptor and morphine
12) Confidence 0.78 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058753 Disease Relevance 0.39 Pain Relevance 0.77
Morphine treatment modulates a variety of immunological parameters, including tumor necrosis factor-alpha (TNF-alpha) production by activated macrophages in vitro.
Gene_expression (production) of tumor necrosis factor-alpha in macrophages associated with necrosis, cancer and morphine
13) Confidence 0.78 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058753 Disease Relevance 0.35 Pain Relevance 0.50
Since the increased incidence of bacterial and viral infections in opioid addicts is well documented, it is suggested that the inhibitory effect of morphine on TNF-alpha production might play a substantial role in the increased vulnerability of these individuals to certain infections.
Gene_expression (production) of TNF-alpha associated with viral infection, opioid, infection and morphine
14) Confidence 0.78 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058753 Disease Relevance 0.47 Pain Relevance 0.74
There was significant attenuation of oxidative stress as well as TNF-alpha levels.
Gene_expression (levels) of TNF-alpha associated with stress
15) Confidence 0.78 Published 2009 Journal Immunobiology Section Abstract Doc Link 19159825 Disease Relevance 1.42 Pain Relevance 0.19
Spinal and supraspinal changes in tumor necrosis factor-alpha expression following excitotoxic spinal cord injury.
Gene_expression (expression) of tumor necrosis factor-alpha in Spinal associated with pain, necrosis, cancer and spinal cord
16) Confidence 0.78 Published 2007 Journal J. Mol. Neurosci. Section Title Doc Link 17416966 Disease Relevance 1.19 Pain Relevance 0.38
TNFalpha and IL-1alpha mRNAs were expressed, whereas TNFalpha but not IL-1alpha protein was synthesized in intact PNS of C57/BL mice.
Neg (not) Gene_expression (synthesized) of TNFalpha in PNS
17) Confidence 0.78 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.41 Pain Relevance 0.28
In contrast to rapid-WD, the production of TNFalpha, IL-1alpha, and IL-1beta protein was deficient in slow-WD, although their mRNAs were expressed. mRNA expression and protein production of TNFalpha, IL-1alpha, and IL-1beta were differentially regulated during rapid-WD and slow-WD, suggesting that mRNA expression, by itself, is no indication of the functional involvement of cytokines in WD.
Gene_expression (production) of TNFalpha associated with wallerian degeneration and cytokine
18) Confidence 0.78 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.40 Pain Relevance 0.27
TNFalpha and IL-1alpha mRNAs were expressed, whereas TNFalpha but not IL-1alpha protein was synthesized in intact PNS of C57/BL mice.
Gene_expression (expressed) of TNFalpha in PNS
19) Confidence 0.78 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.37 Pain Relevance 0.28
Thereafter, recruited macrophages contributed to the production of TNFalpha, IL-1alpha, and IL-1beta, which in turn augmented myelin phagocytosis by macrophages.
Gene_expression (production) of TNFalpha in macrophages
20) Confidence 0.78 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.54 Pain Relevance 0.35

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