INT64888

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Context Info
Confidence 0.16
First Reported 1996
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 52
Total Number 52
Disease Relevance 34.33
Pain Relevance 5.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (HBM)
Anatomy Link Frequency
blood 5
plasma 4
platelet 3
upper 2
body 2
HBM (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 55 98.94 Very High Very High Very High
sSRI 19 98.62 Very High Very High Very High
Inflammation 65 96.20 Very High Very High Very High
headache 48 95.60 Very High Very High Very High
imagery 168 94.56 High High
positron emission tomography 202 94.44 High High
diclofenac 2 94.40 High High
Pain 125 93.72 High High
abdominal pain 32 92.40 High High
pruritus 4 89.36 High High
Disease Link Frequency Relevance Heat
Cancer 304 100.00 Very High Very High Very High
Hemolytic Anemia 17 99.90 Very High Very High Very High
Body Weight 49 99.84 Very High Very High Very High
Insulin Resistance 139 99.80 Very High Very High Very High
Hypogonadotropic Hypogonadism 76 99.80 Very High Very High Very High
Thrombosis Related Under Development 20 99.70 Very High Very High Very High
Hemorrhage 131 99.60 Very High Very High Very High
Reprotox - General 1 126 99.58 Very High Very High Very High
Hematoma 4 99.54 Very High Very High Very High
Surgical Blood Loss 4 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Twelve hours after admission the patient presented with an episode of upper GI bleeding, and a significant decrease of tumor size and hemoglobin level.
Negative_regulation (decrease) of hemoglobin in upper associated with cancer and hemorrhage
1) Confidence 0.16 Published 2008 Journal World J Surg Oncol Section Abstract Doc Link PMC2486266 Disease Relevance 1.33 Pain Relevance 0.09
Finally, by a significant decrease of hemoglobin levels less then 12 hours after the patient's admission.
Negative_regulation (decrease) of hemoglobin
2) Confidence 0.12 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2486266 Disease Relevance 2.21 Pain Relevance 0.11
Twelve hours after admission the patient presented with an episode of upper gastrointestinal (GI) bleeding, a significant reduction of the palpable mass to 25 × 25 cm, and a decrease of the patient's hemoglobin level to 6.4 mg/dl.
Negative_regulation (decrease) of hemoglobin in upper associated with hemorrhage
3) Confidence 0.12 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2486266 Disease Relevance 0.61 Pain Relevance 0.05
Furthermore, a consistent decrease in hemoglobin was reported during rhIL-6 treatment.
Negative_regulation (decrease) of hemoglobin
4) Confidence 0.12 Published 1996 Journal Leuk. Lymphoma Section Abstract Doc Link 8833392 Disease Relevance 0.43 Pain Relevance 0.11
Bonferroni post-test performed on this reduced dataset still demonstrates the same significant decrease in hemoglobin, hematocrit and RBC values from pre-18F-FLT to immediately post-18F-FLT times but without subsequent lowering at later time points.
Negative_regulation (decrease) of hemoglobin
5) Confidence 0.10 Published 2007 Journal BMC Nucl Med Section Body Doc Link PMC1931583 Disease Relevance 0.39 Pain Relevance 0.19
As described in the results section, decreases in the patients' average hematocrit, RBC and hemoglobin levels were observed.
Negative_regulation (decreases) of hemoglobin
6) Confidence 0.10 Published 2007 Journal BMC Nucl Med Section Body Doc Link PMC1931583 Disease Relevance 0.46 Pain Relevance 0.32
The initial decrease in hemoglobin, hematocrit and RBC is probably attributable to a dilution effect since patients were hydrated with 500 cc of IV normal saline during the PET scan.
Negative_regulation (decrease) of hemoglobin associated with positron emission tomography
7) Confidence 0.10 Published 2007 Journal BMC Nucl Med Section Body Doc Link PMC1931583 Disease Relevance 0.46 Pain Relevance 0.30
Her estimated blood loss was more than 600 mL in 24 hours reducing her hemoglobin level from 131 g/L to 109 g/L.
Negative_regulation (reducing) of hemoglobin in blood associated with pressure volume 2 under development
8) Confidence 0.10 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911469 Disease Relevance 0.51 Pain Relevance 0.10
Further decrease in glycated hemoglobin following ingestion of a LoBAG30 diet for 10 weeks compared to 5 weeks in people with untreated type 2 diabetes

Background

Negative_regulation (decrease) of hemoglobin associated with diabetes mellitus
9) Confidence 0.09 Published 2010 Journal Nutr Metab (Lond) Section Title Doc Link PMC2923629 Disease Relevance 0.30 Pain Relevance 0
By including all of these parameters in the experimental design, we have been able to provide sound scientific evidence that not only is blood glucose control improved, evidenced by a decrease in total glycated hemoglobin from 10.0 to 7.5, (?
Negative_regulation (decrease) of hemoglobin in blood
10) Confidence 0.09 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2923629 Disease Relevance 0.33 Pain Relevance 0
The reason the decrease in glycated hemoglobin was linear and lower than predicted, we suspect, is because there is a continuing metabolic adaptation in these subjects as a result of a continuing decrease in fasting glucose concentration over the period of the study.
Negative_regulation (decrease) of hemoglobin
11) Confidence 0.09 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2923629 Disease Relevance 0 Pain Relevance 0
The mean glycated hemoglobin decreased from 10.0% at baseline to 8.7% at 5 weeks.
Negative_regulation (decreased) of hemoglobin
12) Confidence 0.09 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2923629 Disease Relevance 0 Pain Relevance 0
All of these diets lowered the integrated 24-hour glucose concentration and resulted in a significant decrease in glycated hemoglobin [8-10].
Negative_regulation (decrease) of hemoglobin
13) Confidence 0.09 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2923629 Disease Relevance 0 Pain Relevance 0
We previously determined that a weight-maintenance, non-ketogenic diet containing 30% carbohydrate (CHO), 30% protein, 40% fat, (30:30:40) (LoBAG30) decreased glycated hemoglobin (%tGHb) from 10.8 to 9.1% over a 5 week period in subjects with untreated type 2 diabetes.
Negative_regulation (decreased) of hemoglobin in fat associated with diabetes mellitus
14) Confidence 0.09 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2923629 Disease Relevance 0.24 Pain Relevance 0
Blood pressure slowly decreased to 60 mmHg, blood CPK levels reached 135 000 U/L, blood hemoglobin decreased to 6.9 g/dL, and platelets decreased to 100 000 mm3.
Negative_regulation (decreased) of hemoglobin in Blood
15) Confidence 0.09 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661629 Disease Relevance 0.45 Pain Relevance 0.11
Only albumin, red blood cell count, hematocrit and hemoglobin showed a statistically significant decrease over time.
Negative_regulation (decrease) of hemoglobin in red blood cell
16) Confidence 0.07 Published 2007 Journal BMC Nucl Med Section Abstract Doc Link PMC1931583 Disease Relevance 0.28 Pain Relevance 0.23
Furthermore, a smaller decrease in hemoglobin and hematocrit was found in the finasteride group (P < 0.0001).
Negative_regulation (decrease) of hemoglobin
17) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710385 Disease Relevance 0.69 Pain Relevance 0
Grade 4 events occurred in two patients: one patient (2.6%) in the placebo plus dacarbazine group had Grade 4 reduction in neutrophils and one patient (2.6%) in the bosentan plus dacarbazine group had Grade 4 reduction in hemoglobin.
Negative_regulation (reduction) of hemoglobin in neutrophils
18) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2856553 Disease Relevance 0.71 Pain Relevance 0.08
Erythrocytosis can develop during testosterone treatment, especially in older men treated by injectable testosterone preparations.45 Hemoglobin at puberty increases 15% to 20% in boys, men have higher levels of hemoglobin than women, and hypogonadism causes a decline in hemoglobin levels that can be restored with testosterone replacement therapy.139,300 But the elevation in hemoglobin above certain levels may have bad outcomes, particularly in elderly, because the increase in blood viscosity could exacerbate vascular disease in the coronary, cerebrovascular, or peripheral vascular circulation, especially in people with other diseases that cause secondary polycythemia, ie, chronic obstructive pulmonary disease.301–303 Injection is associated with higher potentials for erythrocytosis than topical preparations.240 Snyder et al noticed that erythrocytosis occurred in 5.5% of scrotal transdermal users, and the majority of changes took place over the first three months of treatment.92 It has been demonstrated that testosterone dosage correlates with the incidence of erythrocytosis,67 The frequency of polycythemia (hematocrit over 51%) is related most of the time to supra-physiological levels.240 The resolution of erythrocytosis (hematocrit >52%), untreated obstructive sleep apnea, or untreated severe congestive heart failure, is required before starting on testosterone treatment.19,58,304
Negative_regulation (decline) of hemoglobin in blood associated with apnoea, transdermal, pulmonary disease, hypogonadotropic hypogonadism, erythrocytosis, frailty, disease and increased venous pressure under development
19) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701485 Disease Relevance 1.81 Pain Relevance 0.07
Despite transfusion, hemoglobin was noted to have declined to 3.3 g/dl.
Negative_regulation (declined) of hemoglobin
20) Confidence 0.06 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2546413 Disease Relevance 1.09 Pain Relevance 0.13

General Comments

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