INT6489

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 9
Speculated 4
Reported most in Abstract
Documents 140
Total Number 144
Disease Relevance 92.31
Pain Relevance 67.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
macrophage 38
lungs 12
monocytes 9
leukocyte 8
T-cell 8
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 621 100.00 Very High Very High Very High
cytokine 499 100.00 Very High Very High Very High
Paracetamol 202 100.00 Very High Very High Very High
chemokine 127 100.00 Very High Very High Very High
ischemia 58 100.00 Very High Very High Very High
Spinal cord 23 100.00 Very High Very High Very High
Glutamate 16 100.00 Very High Very High Very High
substance P 9 100.00 Very High Very High Very High
Infliximab 111 99.98 Very High Very High Very High
Morphine 88 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 709 100.00 Very High Very High Very High
Cancer 186 100.00 Very High Very High Very High
Necrosis 134 100.00 Very High Very High Very High
Cv Unclassified Under Development 66 100.00 Very High Very High Very High
Alzheimer's Dementia 28 100.00 Very High Very High Very High
Coronavirus Infection 4 100.00 Very High Very High Very High
Urological Neuroanatomy 3 100.00 Very High Very High Very High
Injury 429 99.98 Very High Very High Very High
Obesity 24 99.98 Very High Very High Very High
Hyperalgesia 9 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, gasless suspension and pneumoperitoneum did not lead to an increase in tumor necrosis factor alpha or nitric oxide production by peritoneal macrophages.
Positive_regulation (increase) of Gene_expression (production) of tumor necrosis factor alpha in peritoneal macrophages
1) Confidence 0.70 Published 1997 Journal J. Am. Coll. Surg. Section Body Doc Link 9100680 Disease Relevance 0 Pain Relevance 0
In addition, macrophage production of tumor necrosis factor alpha and nitric oxide, two markers of macrophage stress, 24 hours after operation was significantly increased in the laparotomy group compared with animals serving as controls.
Positive_regulation (increased) of Gene_expression (production) of tumor necrosis factor alpha in macrophage
2) Confidence 0.70 Published 1997 Journal J. Am. Coll. Surg. Section Body Doc Link 9100680 Disease Relevance 0 Pain Relevance 0
The aim of our study was to clarify the effect of morphine on lipopolysaccharide (LPS)-induced TNF-alpha production in vivo.
Positive_regulation (induced) of Gene_expression (production) of TNF-alpha associated with morphine
3) Confidence 0.70 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058753 Disease Relevance 0.39 Pain Relevance 0.57
Effect of morphine on lipopolysaccharide-induced tumor necrosis factor-alpha production in vivo: involvement of the sympathetic nervous system.
Positive_regulation (induced) of Gene_expression (production) of tumor necrosis factor-alpha in sympathetic nervous system associated with necrosis, cancer, narcan and morphine
4) Confidence 0.70 Published 1997 Journal J. Neuroimmunol. Section Title Doc Link 9058753 Disease Relevance 0.45 Pain Relevance 0.75
It is concluded that (i) systemic administration of morphine inhibits LPS-induced TNF-alpha production in vivo via 'classic' opioid receptors; (ii) this effect requires intact sympathetic outflow.
Positive_regulation (induced) of Gene_expression (production) of TNF-alpha in outflow associated with opioid receptor and morphine
5) Confidence 0.70 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058753 Disease Relevance 0.39 Pain Relevance 0.77
Subcutaneous injection of morphine decreased LPS-induced TNF-alpha production throughout the response, an effect that was dose-dependent and reversible by naloxone.
Positive_regulation (induced) of Gene_expression (production) of TNF-alpha associated with narcan and morphine
6) Confidence 0.70 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058753 Disease Relevance 0.39 Pain Relevance 0.72
RESULTS: Morphine alone did not enhance the generation of TNF-alpha by mesangial cells, however, an enhanced (P < 0.001) TNF-alpha production was observed when mesangial cells were first treated with morphine for 18 h and then activated further with LPS.
Positive_regulation (enhanced) of Gene_expression (production) of TNF-alpha in mesangial cells
7) Confidence 0.69 Published 2000 Journal Inflammation Section Body Doc Link 10921509 Disease Relevance 0.14 Pain Relevance 0
These studies show that morphine withdrawal sensitizes to LPS lethality via increased production of TNF-alpha.
Positive_regulation (increased) of Gene_expression (production) of TNF-alpha associated with withdrawal and morphine
8) Confidence 0.69 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15913793 Disease Relevance 0 Pain Relevance 0.68
By using alpha2- and beta-adrenergic drugs (clonidine, CH-38083, isoproterenol, propranolol) we provided the first in vivo evidence that, beside the dominance of neuronal alpha2- and macrophage beta-adrenoceptors, the alpha2-adrenoceptors on macrophages were also involved in the modulation of LPS-induced TNF-alpha production.
Positive_regulation (-) of Gene_expression (production) of TNF-alpha in macrophage associated with clonidine
9) Confidence 0.69 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10674987 Disease Relevance 0.14 Pain Relevance 0.14
We found that reduction of the sympathetic outflow by reserpine dramatically increased the lipopolysaccharide (LPS)-induced TNF-alpha production, demonstrating that the release of endogenous noradrenaline (NA), controlled by presynaptic alpha2-adrenoceptors, was a determinant factor in this model.
Positive_regulation (induced) of Gene_expression (production) of TNF-alpha in outflow associated with noradrenaline
10) Confidence 0.69 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10674987 Disease Relevance 0.18 Pain Relevance 0.13
We found that reduction of the sympathetic outflow by reserpine dramatically increased the lipopolysaccharide (LPS)-induced TNF-alpha production, demonstrating that the release of endogenous noradrenaline (NA), controlled by presynaptic alpha2-adrenoceptors, was a determinant factor in this model.
Positive_regulation (-) of Gene_expression (production) of TNF-alpha in outflow associated with noradrenaline
11) Confidence 0.69 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10674987 Disease Relevance 0.18 Pain Relevance 0.13
Finally, because of documented incremented production of TNFalpha, TNFalpha blocking agents should be effectively utilized.
Positive_regulation (incremented) of Gene_expression (production) of TNFalpha
12) Confidence 0.69 Published 2004 Journal Recenti Prog Med Section Abstract Doc Link 15560297 Disease Relevance 0.47 Pain Relevance 0.31
Tenidap, a compound reported to inhibit 5-lipoxygenase, cyclooxygenase and cytokine production, also stimulated TNF alpha production while the 5-lipoxygenase inhibitor, phenidone, was inactive.
Positive_regulation (stimulated) of Gene_expression (production) of TNF alpha associated with cytokine
13) Confidence 0.67 Published 1993 Journal Drugs Exp Clin Res Section Abstract Doc Link 8013267 Disease Relevance 0.64 Pain Relevance 0.67
Neither acetaminophen nor nabumetone was found to stimulate TNF alpha production significantly.
Positive_regulation (stimulate) of Gene_expression (production) of TNF alpha associated with paracetamol
14) Confidence 0.67 Published 1993 Journal Drugs Exp Clin Res Section Abstract Doc Link 8013267 Disease Relevance 0.67 Pain Relevance 0.70
In the current study, the authors utilized LPS-induced TNF alpha production in the Balb/c mouse to evaluate the activity of a classical NSAID, a mixed inhibitor, and SmithKline Beecham cytokine suppressive antiinflammatory drugs (CSAID).
Positive_regulation (-) of Gene_expression (production) of TNF alpha associated with inflammation, cinod and cytokine
15) Confidence 0.67 Published 1993 Journal Drugs Exp Clin Res Section Abstract Doc Link 8013267 Disease Relevance 0.74 Pain Relevance 0.63
APAP exposure for 24h significantly increased plasma level of blood urea nitrogen (BUN), creatinine, uric acid, TNF-alpha, NO production, urinary gamma-glutamyl transpeptidase (gamma-GT) activity, total urinary protein and urinary glucose level accompanied by a decrease in Na(+)-K(+)-ATPase activity.
Positive_regulation (increased) of Gene_expression (production) of TNF-alpha in blood associated with paracetamol
16) Confidence 0.67 Published 2010 Journal Toxicology Section Abstract Doc Link 20067817 Disease Relevance 0.44 Pain Relevance 0.81
We have previously demonstrated that Leu-Ile, which induces the expression of not only tumor necrosis factor-alpha (TNF-alpha) but also glial cell line-derived neurotrophic factor (GDNF), inhibits methamphetamine (METH) and morphine (MOR)-induced sensitization and rewarding effects by regulating extracellular dopamine levels via the induction of TNF-alpha expression, and indicated the potential of Leu-Ile as a novel therapeutic agent for METH and MOR-induced dependence.
Positive_regulation (induction) of Gene_expression (expression) of TNF-alpha in glial cell associated with addiction, necrosis, dopamine, cancer and morphine
17) Confidence 0.67 Published 2007 Journal Behav. Brain Res. Section Abstract Doc Link 17331595 Disease Relevance 0.28 Pain Relevance 0.88
Backcrossing to transgenic mice overexpressing TNF-alpha in their islet beta cells (which also remain normoglycemic, (1)) yielded double transgenics, most of which became diabetic by the age of 4 months; histological analysis revealed a dramatic decrease in insulin-containing beta cells.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TNF-alpha in beta cells associated with targeted disruption and diabetes mellitus
18) Confidence 0.67 Published 1995 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8554587 Disease Relevance 0.61 Pain Relevance 0.12
Conversely, PAG had no effect on LPS-induced production of the hypernociceptive cytokines, TNF-alpha, IL-1beta and CXCL1/KC and on hypernociception induced by PGE(2), a directly acting hypernociceptive mediator.
Positive_regulation (induced) of Gene_expression (production) of TNF-alpha associated with urological neuroanatomy and cytokine
19) Confidence 0.67 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18585702 Disease Relevance 0.51 Pain Relevance 0.12
LPS induced a concentration-dependent increase in the production of NO or TNF-alpha from the mouse primary mixed glia cultures.
Positive_regulation (induced) of Gene_expression (production) of TNF-alpha
20) Confidence 0.67 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8996182 Disease Relevance 0.18 Pain Relevance 0.52

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