INT649

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Context Info
Confidence 0.55
First Reported 1977
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.50
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Afp) extracellular space (Afp) extracellular region (Afp)
cytoplasm (Afp)
Anatomy Link Frequency
plasma 1
embryo 1
liver 1
mesentery 1
Afp (Mus musculus)
Pain Link Frequency Relevance Heat
abdominal pain 6 99.40 Very High Very High Very High
palliative 4 99.36 Very High Very High Very High
imagery 11 98.64 Very High Very High Very High
Pain 2 96.16 Very High Very High Very High
medulla 3 72.12 Quite High
orphanin 2 50.00 Quite Low
Paracetamol 1 39.60 Quite Low
alcohol 1 37.84 Quite Low
sodium channel 1 19.36 Low Low
tetrodotoxin 1 17.44 Low Low
Disease Link Frequency Relevance Heat
Diarrhoea 2 99.92 Very High Very High Very High
Telangiectasia 76 99.84 Very High Very High Very High
Hepatitis 1 99.58 Very High Very High Very High
Abdominal Pain 6 99.40 Very High Very High Very High
Cerebral Palsy 6 99.16 Very High Very High Very High
Immunodeficiency 11 99.12 Very High Very High Very High
Ataxia 126 98.82 Very High Very High Very High
Cancer 23 98.60 Very High Very High Very High
Cirrhosis 2 98.52 Very High Very High Very High
Frailty 13 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated serum alpha-foetoprotein levels were noted in all cases.
Positive_regulation (Elevated) of serum alpha-foetoprotein
1) Confidence 0.55 Published 2008 Journal Cancer Lett. Section Abstract Doc Link 18308466 Disease Relevance 0.38 Pain Relevance 0.15
The alpha fetoprotein ratio was high and increased as pregnancy progressed.
Positive_regulation (increased) of alpha fetoprotein
2) Confidence 0.45 Published 1983 Journal J Gynecol Obstet Biol Reprod (Paris) Section Abstract Doc Link 6863866 Disease Relevance 0.67 Pain Relevance 0.10
The PB should be included in the differential diagnosis of a mass in the pancreas or mesentery, especially with elevated AFP and a well-defined heterogeneous imaging finding.
Positive_regulation (elevated) of AFP in mesentery associated with imagery
3) Confidence 0.37 Published 2008 Journal Cancer Lett. Section Abstract Doc Link 18308466 Disease Relevance 0.19 Pain Relevance 0.15
Induction of the synthesis of the embryo-specific protein--alpha-fetoprotein (alpha-FP) was revealed in the SWR mice of different age after one or several CCl4 treatments.
Positive_regulation (Induction) of alpha-fetoprotein in embryo
4) Confidence 0.36 Published 1977 Journal Biull Eksp Biol Med Section Abstract Doc Link 70250 Disease Relevance 0.19 Pain Relevance 0
The majority had cirrhosis of the liver, were positive for markers of hepatitis B virus, and showed elevated serum alpha fetoprotein (AFP).
Positive_regulation (elevated) of serum alpha fetoprotein in liver associated with cirrhosis and hepatitis
5) Confidence 0.22 Published 1992 Journal Int Surg Section Abstract Doc Link 1336000 Disease Relevance 1.00 Pain Relevance 0.10
Afp, Fabp2, Foxa2 and Sox17 were elevated (fig. 2h).
Positive_regulation (elevated) of Afp
6) Confidence 0.21 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0 Pain Relevance 0
While the critical importance of the AFP for song learning has been established, its specific role remains unknown [14].
Positive_regulation (importance) of AFP
7) Confidence 0.08 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1069649 Disease Relevance 0.23 Pain Relevance 0.04
RESULTS: The importance and the curiosity of the presented case was the novel finding of the progressive elevation of plasma nociceptin level up to 17-fold (172 pg/mL) above the baseline (9.2+/-1.8 pg/mL), parallel with the elevation of alpha fetoprotein (from 13 ng/mL up to 3 480 ng/mL) during tumor development.
Positive_regulation (elevation) of alpha fetoprotein in plasma
8) Confidence 0.02 Published 2004 Journal World J. Gastroenterol. Section Body Doc Link 14695788 Disease Relevance 0.15 Pain Relevance 0
Serum levels of alpha fetoprotein (AFP) are usually increased in A-T patients [4-6].
Positive_regulation (increased) of alpha fetoprotein associated with telangiectasia
9) Confidence 0.02 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2662841 Disease Relevance 1.70 Pain Relevance 0
Other tests that may support the diagnosis are: serum alpha-fetoprotein is elevated above 10 ng/ml in more than 90% of patients; cytogenetic analysis shows a 7:14 translocation (t [7;14] [q11;q32]) in 5–15% of affected individuals; colony in vitro assay (irradiation of colony formation of lymphoblastoid cells) is a very sensitive test but takes approximately three months and is available only in specialized centres.
Positive_regulation (elevated) of alpha-fetoprotein
10) Confidence 0.02 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 0.78 Pain Relevance 0.10
By age 3 years, she had progressively worsening ataxia, choreoathetosis, prominent ocular telangiectasias and an elevated alpha fetoprotein of 205.4 ng/mL (normal 0–6 ng/mL) consistent with ataxia-telangiectasia.
Positive_regulation (elevated) of alpha fetoprotein associated with telangiectasia, ataxia and cerebral palsy
11) Confidence 0.01 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2662841 Disease Relevance 1.22 Pain Relevance 0

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