INT649

Context Info Confidence 0.55 First Reported 1977 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 11 Disease Relevance 6.50 Pain Relevance 0.62

transport (Afp) extracellular space (Afp) extracellular region (Afp) cytoplasm (Afp)

Anatomy Link Frequency plasma 1 embryo 1 liver 1 mesentery 1 Afp (Mus musculus)

Pain Link Frequency Relevance Heat abdominal pain 6 99.40 palliative 4 99.36 imagery 11 98.64 Pain 2 96.16 medulla 3 72.12 orphanin 2 50.00 Paracetamol 1 39.60 alcohol 1 37.84 sodium channel 1 19.36 tetrodotoxin 1 17.44

Disease Link Frequency Relevance Heat Diarrhoea 2 99.92 Telangiectasia 76 99.84 Hepatitis 1 99.58 Abdominal Pain 6 99.40 Cerebral Palsy 6 99.16 Immunodeficiency 11 99.12 Ataxia 126 98.82 Cancer 23 98.60 Cirrhosis 2 98.52 Frailty 13 97.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Elevated serum alpha-foetoprotein levels were noted in all cases.

Positive_regulation (Elevated) of serum alpha-foetoprotein

1) Confidence 0.55 Published 2008 Journal Cancer Lett. Section Abstract Doc Link 18308466 Disease Relevance 0.38 Pain Relevance 0.15

The alpha fetoprotein ratio was high and increased as pregnancy progressed.

Positive_regulation (increased) of alpha fetoprotein

2) Confidence 0.45 Published 1983 Journal J Gynecol Obstet Biol Reprod (Paris) Section Abstract Doc Link 6863866 Disease Relevance 0.67 Pain Relevance 0.10

The PB should be included in the differential diagnosis of a mass in the pancreas or mesentery, especially with elevated AFP and a well-defined heterogeneous imaging finding.

Positive_regulation (elevated) of AFP in mesentery associated with imagery

3) Confidence 0.37 Published 2008 Journal Cancer Lett. Section Abstract Doc Link 18308466 Disease Relevance 0.19 Pain Relevance 0.15

Induction of the synthesis of the embryo-specific protein--alpha-fetoprotein (alpha-FP) was revealed in the SWR mice of different age after one or several CCl4 treatments.

Positive_regulation (Induction) of alpha-fetoprotein in embryo

4) Confidence 0.36 Published 1977 Journal Biull Eksp Biol Med Section Abstract Doc Link 70250 Disease Relevance 0.19 Pain Relevance 0

The majority had cirrhosis of the liver, were positive for markers of hepatitis B virus, and showed elevated serum alpha fetoprotein (AFP).

Positive_regulation (elevated) of serum alpha fetoprotein in liver associated with cirrhosis and hepatitis

5) Confidence 0.22 Published 1992 Journal Int Surg Section Abstract Doc Link 1336000 Disease Relevance 1.00 Pain Relevance 0.10

Afp, Fabp2, Foxa2 and Sox17 were elevated (fig. 2h).

Positive_regulation (elevated) of Afp

6) Confidence 0.21 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0 Pain Relevance 0

While the critical importance of the AFP for song learning has been established, its specific role remains unknown [14].

Positive_regulation (importance) of AFP

7) Confidence 0.08 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1069649 Disease Relevance 0.23 Pain Relevance 0.04

RESULTS: The importance and the curiosity of the presented case was the novel finding of the progressive elevation of plasma nociceptin level up to 17-fold (172 pg/mL) above the baseline (9.2+/-1.8 pg/mL), parallel with the elevation of alpha fetoprotein (from 13 ng/mL up to 3 480 ng/mL) during tumor development.

Positive_regulation (elevation) of alpha fetoprotein in plasma

8) Confidence 0.02 Published 2004 Journal World J. Gastroenterol. Section Body Doc Link 14695788 Disease Relevance 0.15 Pain Relevance 0

Serum levels of alpha fetoprotein (AFP) are usually increased in A-T patients [4-6].

Positive_regulation (increased) of alpha fetoprotein associated with telangiectasia

9) Confidence 0.02 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2662841 Disease Relevance 1.70 Pain Relevance 0

Other tests that may support the diagnosis are: serum alpha-fetoprotein is elevated above 10 ng/ml in more than 90% of patients; cytogenetic analysis shows a 7:14 translocation (t [7;14] [q11;q32]) in 5–15% of affected individuals; colony in vitro assay (irradiation of colony formation of lymphoblastoid cells) is a very sensitive test but takes approximately three months and is available only in specialized centres.

Positive_regulation (elevated) of alpha-fetoprotein

10) Confidence 0.02 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 0.78 Pain Relevance 0.10

By age 3 years, she had progressively worsening ataxia, choreoathetosis, prominent ocular telangiectasias and an elevated alpha fetoprotein of 205.4 ng/mL (normal 0–6 ng/mL) consistent with ataxia-telangiectasia.

Positive_regulation (elevated) of alpha fetoprotein associated with telangiectasia, ataxia and cerebral palsy

11) Confidence 0.01 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2662841 Disease Relevance 1.22 Pain Relevance 0

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