INT6490

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Context Info
Confidence 0.58
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 145
Total Number 147
Disease Relevance 26.25
Pain Relevance 70.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADCY1) small molecule metabolic process (ADCY1) plasma membrane (ADCY1)
nucleus (ADCY1) GTPase activity (ADCY1) transmembrane transport (ADCY1)
Anatomy Link Frequency
brain 5
smooth muscle 3
platelet 3
embryonic kidney 3
ovary 3
ADCY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 55 100.00 Very High Very High Very High
Calcitonin gene-related peptide 30 100.00 Very High Very High Very High
opioid receptor 204 99.98 Very High Very High Very High
Opioid 146 99.98 Very High Very High Very High
Enkephalin 63 99.98 Very High Very High Very High
Clonidine 27 99.98 Very High Very High Very High
MU agonist 21 99.98 Very High Very High Very High
agonist 1333 99.92 Very High Very High Very High
Morphine 102 99.92 Very High Very High Very High
cINOD 18 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 99 99.76 Very High Very High Very High
Headache 11 99.48 Very High Very High Very High
Neuroblastoma 74 99.28 Very High Very High Very High
Rheumatoid Arthritis 11 99.24 Very High Very High Very High
INFLAMMATION 86 99.20 Very High Very High Very High
Hyperglycemia 9 99.12 Very High Very High Very High
Hypertrophy 1 98.86 Very High Very High Very High
Cluster Headache 5 98.56 Very High Very High Very High
Opiate Addiction 16 98.48 Very High Very High Very High
Hypersensitivity 46 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All the 5-HT(1) receptor types actually interact with G alpha i/G alpha o proteins to inhibit adenylyl cyclase and modulate ionic effectors, i.e. potassium and/or calcium channels.
Negative_regulation (inhibit) of adenylyl cyclase associated with calcium channel
1) Confidence 0.58 Published 2004 Journal Curr Drug Targets CNS Neurol Disord Section Abstract Doc Link 14965240 Disease Relevance 0.06 Pain Relevance 0.28
LPA has multiple cellular effects, including the stimulation of phospholipases, the mobilization of [Ca2+]i, and the inhibition of adenylate cyclase (12).
Negative_regulation (inhibition) of adenylate cyclase
2) Confidence 0.57 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908795 Disease Relevance 0 Pain Relevance 0
In isolated cardiac myocytes, muscarinic cholinergic agonists reduce and/or eliminate beta-adrenergic stimulation of the Ca2+ current (ICa), possibly by G-protein dependent inhibition of the adenylate cyclase.
Negative_regulation (inhibition) of adenylate cyclase in cardiac myocytes associated with agonist
3) Confidence 0.57 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0 Pain Relevance 0.11
Bradykinin stimulates Ca2+ mobilization in NCB-20 cells leading to direct inhibition of adenylylcyclase.
Negative_regulation (inhibition) of adenylylcyclase associated with bradykinin
4) Confidence 0.57 Published 1991 Journal J. Biol. Chem. Section Title Doc Link 1848232 Disease Relevance 0 Pain Relevance 0.25
We examined how lidocaine affects muscarinic receptor-mediated inhibition of adenylyl cyclase in bovine tracheal smooth muscles.
Negative_regulation (inhibition) of adenylyl cyclase in smooth muscles associated with lidocaine
5) Confidence 0.56 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12787832 Disease Relevance 0 Pain Relevance 0.48
Lidocaine attenuates muscarinic receptor-mediated inhibition of adenylyl cyclase in airway smooth muscle.
Negative_regulation (inhibition) of adenylyl cyclase in smooth muscle associated with lidocaine
6) Confidence 0.56 Published 2003 Journal Eur. J. Pharmacol. Section Title Doc Link 12787832 Disease Relevance 0 Pain Relevance 0.66
These results suggest that lidocaine prevents muscarinic receptor-mediated signaling pathway and thereby reverses inhibition of adenylyl cyclase by methacholine in bovine tracheal smooth muscle.
Negative_regulation (inhibition) of adenylyl cyclase in smooth muscle associated with lidocaine
7) Confidence 0.56 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12787832 Disease Relevance 0 Pain Relevance 0.61
In HEK 293 cells coexpressing G(z) with the mu- or kappa-opioid receptors, opioid agonists induced inhibition of adenylyl cyclase in a pertussis toxin-insensitive manner.
Negative_regulation (inhibition) of adenylyl cyclase in HEK associated with mu agonist, bordatella infection and kappa opioid receptor
8) Confidence 0.56 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991975 Disease Relevance 0.26 Pain Relevance 0.85
In opioid-induced inhibition of adenylyl cyclase, both G(i) and G(z) proteins can serve as the signal transducer.
Negative_regulation (inhibition) of adenylyl cyclase associated with opioid
9) Confidence 0.56 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991975 Disease Relevance 0.16 Pain Relevance 0.56
Inhibition of adenylyl cyclase activity, which results in decreased formation of cAMP, is an important consequence of alpha 2-adrenoceptor activation.
Negative_regulation (Inhibition) of adenylyl cyclase
10) Confidence 0.55 Published 1995 Journal Ann. Med. Section Abstract Doc Link 8519505 Disease Relevance 0.09 Pain Relevance 0.03
Stimulation of G(i) with the alpha-adrenoceptor agonist clonidine inhibited hCG-induced cyclase activity.
Negative_regulation (inhibited) of cyclase associated with agonist and clonidine
11) Confidence 0.53 Published 2001 Journal Reproduction Section Abstract Doc Link 11226046 Disease Relevance 0 Pain Relevance 0.27
A reduced capability to inhibit forskolin-stimulated adenylyl cyclase activity in headache patients was observed.
Negative_regulation (inhibit) of adenylyl cyclase associated with headache
12) Confidence 0.52 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11298662 Disease Relevance 0.90 Pain Relevance 0.99
The overall pharmacological profile for the human 5-HT1Dbeta receptor, defined using [35S]-GTPgammaS binding, agreed well with that reported for inhibition of forskolin-stimulated adenylyl cyclase.
Negative_regulation (inhibition) of adenylyl cyclase
13) Confidence 0.51 Published 1995 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 8903941 Disease Relevance 0 Pain Relevance 0.30
Collectively, our results show that although Gz mediated opioid-induced inhibition of adenylyl cyclase and activation of ERK1/2, Gz alone was insufficient to mediate opioid-induced adenylyl cyclase supersensitization.
Negative_regulation (inhibition) of adenylyl cyclase associated with opioid
14) Confidence 0.50 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737627 Disease Relevance 0 Pain Relevance 0.58
Recently, opioid receptors have been shown to interact with the pertussis toxin (PTX)-insensitive Gz (a member of the Gi subfamily), which inhibits adenylyl cyclase and stimulates mitogen-activated protein kinases (MAPKs).
Negative_regulation (inhibits) of adenylyl cyclase associated with bordatella infection and opioid receptor
15) Confidence 0.50 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737627 Disease Relevance 0.19 Pain Relevance 0.56
As previously reported for morphine, only a partial tolerance was observed for adenylyl cyclase inhibition by norepinephrine.
Negative_regulation (inhibition) of cyclase associated with tolerance and morphine
16) Confidence 0.48 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1358661 Disease Relevance 0.19 Pain Relevance 1.20
These results indicate that subtypes adenylyl cyclase I, III and VIII, which are activated by calcium, and adenylyl cyclase V and VI, which are inhibited by calcium, are not dominant isoforms in granulosa-lutein cells.
Negative_regulation (inhibited) of cyclase in lutein cells
17) Confidence 0.46 Published 2001 Journal Reproduction Section Abstract Doc Link 11226046 Disease Relevance 0 Pain Relevance 0.23
The results are discussed in relation to the weaker or the lack of adenylate cyclase inhibition promoted by clonidine and indicate that the formation of the lower affinity state of the alpha-receptor is essential to the alpha 2-adrenoceptor-mediated adenylate cyclase inhibition.
Negative_regulation (inhibition) of cyclase associated with clonidine
18) Confidence 0.46 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6277648 Disease Relevance 0.17 Pain Relevance 0.32
The results are discussed in relation to the weaker or the lack of adenylate cyclase inhibition promoted by clonidine and indicate that the formation of the lower affinity state of the alpha-receptor is essential to the alpha 2-adrenoceptor-mediated adenylate cyclase inhibition.
Negative_regulation (inhibition) of cyclase associated with clonidine
19) Confidence 0.46 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6277648 Disease Relevance 0.16 Pain Relevance 0.30
Remarkably, morphine does not stimulate the rapid internalization of either delta or mu opioid receptors, even at high concentrations that strongly inhibit adenylyl cyclase.
Negative_regulation (inhibit) of adenylyl cyclase associated with mu opioid receptor and morphine
20) Confidence 0.44 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8702570 Disease Relevance 0 Pain Relevance 0.87

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