INT64915

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Context Info
Confidence 0.20
First Reported 1996
Last Reported 2009
Negated 0
Speculated 1
Reported most in Title
Documents 4
Total Number 5
Disease Relevance 1.81
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
osteoblasts 2
THP-1 2
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 7 100.00 Very High Very High Very High
cOX1 6 100.00 Very High Very High Very High
Osteoarthritis 2 99.72 Very High Very High Very High
licofelone 1 98.92 Very High Very High Very High
cINOD 21 98.36 Very High Very High Very High
Arthritis 1 86.60 High High
Pain 3 86.20 High High
Inflammation 6 85.84 High High
COX-2 inhibitor 13 84.52 Quite High
Potency 1 66.84 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 2 99.72 Very High Very High Very High
INFLAMMATION 11 97.64 Very High Very High Very High
Lung Cancer 13 94.28 High High
Colon Cancer 10 91.68 High High
Polyps 2 91.00 High High
Cancer 30 90.88 High High
Arthritis 1 86.60 High High
Pain 3 86.20 High High
Death 10 84.32 Quite High
Apoptosis 10 83.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of selective inhibition of the inducible cyclooxygenase on renin release in healthy volunteers.
Regulation (Effect) of Negative_regulation (inhibition) of cyclooxygenase
1) Confidence 0.20 Published 1998 Journal J. Investig. Med. Section Title Doc Link 9737091 Disease Relevance 0.10 Pain Relevance 0.20
Comparative effects of selective cyclooxygenase 1 and cyclooxygenase 2 inhibitors on myeloperoxidase and 3 alpha-hydroxysteroid dehydrogenase.
Regulation (effects) of Negative_regulation (inhibitors) of cyclooxygenase 1 associated with cox2 and cox1
2) Confidence 0.17 Published 1996 Journal J. Enzym. Inhib. Section Title Doc Link 8835932 Disease Relevance 0.10 Pain Relevance 0.71
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
Regulation (effects) of Negative_regulation (inhibition) of cyclooxygenase in osteoblasts associated with osteoarthritis
3) Confidence 0.12 Published 2002 Journal Arthritis Rheum. Section Title Doc Link 12124864 Disease Relevance 0.10 Pain Relevance 0.24
Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk

Both selective cyclooxygenase (COX)-2 inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) have been beneficial pharmacological agents for many patients suffering from arthritis pain and inflammation.

Spec (possible) Regulation (Effect) of Negative_regulation (inhibition) of cyclooxygenase in THP-1 associated with pain, inflammation, cinod and arthritis
4) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC1860062 Disease Relevance 0.61 Pain Relevance 0.48
This effect does not involve cyclooxygenase (COX) inhibition.
Regulation (involve) of Negative_regulation (inhibition) of cyclooxygenase
5) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2686156 Disease Relevance 0.91 Pain Relevance 0.12

General Comments

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