INT64916

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.24
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (DHRS9) endoplasmic reticulum (DHRS9)
Anatomy Link Frequency
paw 1
DHRS9 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 10 99.80 Very High Very High Very High
Analgesic 8 98.28 Very High Very High Very High
cOX1 18 96.56 Very High Very High Very High
COX2 18 93.36 High High
Opioid 1 91.80 High High
Potency 3 85.84 High High
COX-2 inhibitor 1 83.52 Quite High
Disease Link Frequency Relevance Heat
Toxicity 4 99.24 Very High Very High Very High
Pressure And Volume Under Development 4 99.00 Very High Very High Very High
INFLAMMATION 7 98.70 Very High Very High Very High
Peritonitis 2 96.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primary PGs are potent inhibitors of ADT oxidation, while indomethacin, a prostaglandin blocker, powerfully inhibits 3alpha-HSD reduction and ADT oxidation.
Negative_regulation (reduction) of 3alpha-HSD
1) Confidence 0.57 Published 2007 Journal Med. Hypotheses Section Abstract Doc Link 17382481 Disease Relevance 0 Pain Relevance 0.40
All the compounds inhibited the 3 alpha-HSD, but no correlation was observed with the paw edema inhibition values.
Negative_regulation (inhibited) of 3 alpha-HSD in paw associated with pressure and volume under development
2) Confidence 0.42 Published 1998 Journal Farmaco Section Abstract Doc Link 9679285 Disease Relevance 0.55 Pain Relevance 0.08
The compounds were tested for analgesic and antiinflammatory activities, acute toxicity, ulcerogenic effect, and as in vitro inhibitors of 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD), since it is claimed that the inhibition of such an enzyme predicts in vivo antiinflammatory activity.
Negative_regulation (inhibitors) of 3 alpha-HSD associated with toxicity, inflammation and analgesic
3) Confidence 0.42 Published 1998 Journal Farmaco Section Abstract Doc Link 9679285 Disease Relevance 0.46 Pain Relevance 0.10
We found that compounds within the tri-cyclic aromatic class do not act as potent inhibitors of either myeloperoxidase or 3 alpha-HSD.
Negative_regulation (inhibitors) of 3 alpha-HSD
4) Confidence 0.35 Published 1996 Journal J. Enzym. Inhib. Section Abstract Doc Link 8835932 Disease Relevance 0.06 Pain Relevance 0.64
There is structural and pharmacological evidence that suggests that NSAIDs may also inhibit two unrelated enzymes, myeloperoxidase (MP) and 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD), potentially with untoward consequences for the patient.
Negative_regulation (inhibit) of 3 alpha-HSD associated with cinod
5) Confidence 0.26 Published 1996 Journal J. Enzym. Inhib. Section Abstract Doc Link 8835932 Disease Relevance 0.08 Pain Relevance 0.62
There is structural and pharmacological evidence that suggests that NSAIDs may also inhibit two unrelated enzymes, myeloperoxidase (MP) and 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD), potentially with untoward consequences for the patient.
Negative_regulation (inhibit) of 3 alpha-hydroxysteroid dehydrogenase associated with cinod
6) Confidence 0.22 Published 1996 Journal J. Enzym. Inhib. Section Abstract Doc Link 8835932 Disease Relevance 0.08 Pain Relevance 0.62

General Comments

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