INT64917

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Context Info
Confidence 0.28
First Reported 1996
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.25
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (DHRS9) endoplasmic reticulum (DHRS9)
DHRS9 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 6 100.00 Very High Very High Very High
cOX1 6 100.00 Very High Very High Very High
cINOD 3 98.36 Very High Very High Very High
Analgesic 2 92.52 High High
Potency 1 69.24 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 98.16 Very High Very High Very High
Anxiety Disorder 2 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enzyme 3 alpha-hydroxysteroid dehydrogenase (3 alpha HSD) has been presumed to be the enzyme responsible for the conversion of progesterone to 3 alpha HP, but this has never been confirmed in vitro or in vivo.
Regulation (responsible) of alpha-hydroxysteroid dehydrogenase
1) Confidence 0.28 Published 2001 Journal Endocrinology Section Abstract Doc Link 11606426 Disease Relevance 0.09 Pain Relevance 0.09
Comparative effects of selective cyclooxygenase 1 and cyclooxygenase 2 inhibitors on myeloperoxidase and 3 alpha-hydroxysteroid dehydrogenase.
Regulation (effects) of 3 alpha-hydroxysteroid dehydrogenase associated with cox2 and cox1
2) Confidence 0.23 Published 1996 Journal J. Enzym. Inhib. Section Title Doc Link 8835932 Disease Relevance 0.10 Pain Relevance 0.73
Incubation of both tissues with indomethacin, a known 3 alpha HSD inhibitor, decreased the conversion of progesterone to 3 alpha HP by at least 70%, indicating that 3 alpha HSD was responsible for this conversion.
Regulation (responsible) of 3 alpha HSD
3) Confidence 0.17 Published 2001 Journal Endocrinology Section Abstract Doc Link 11606426 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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