INT6492

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Context Info
Confidence 0.06
First Reported 1992
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ADRA2B) cell-cell signaling (ADRA2B) signal transducer activity (ADRA2B)
Anatomy Link Frequency
tail 1
ADRA2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Sumatriptan 1 100.00 Very High Very High Very High
antagonist 1 99.60 Very High Very High Very High
Analgesic 1 92.80 High High
agonist 4 91.88 High High
Serotonin 2 57.52 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 3 84.64 Quite High
Disease 1 75.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To isolate proteins that may control alpha2-adrenergic receptor function or trafficking, we performed a two-hybrid screen using the carboxy-terminal fourth intracellular tail of the alpha2A-adrenergic receptor as bait.
Regulation (control) of alpha2-adrenergic in tail
1) Confidence 0.06 Published 2006 Journal Cell. Signal. Section Abstract Doc Link 16531006 Disease Relevance 0.31 Pain Relevance 0.18
Examples of the 5-HT1D-like pharmacology displayed by RH-2 include high affinity for the 5-HT1D-selective compound sumatriptan (Ki = 9.4 nM) and for the alpha 2-adrenergic receptor antagonist rauwolscine (Ki = 47 nM).
Regulation (affinity) of alpha 2-adrenergic associated with sumatriptan and antagonist
2) Confidence 0.05 Published 1992 Journal Mol. Pharmacol. Section Abstract Doc Link 1328844 Disease Relevance 0 Pain Relevance 0.20

General Comments

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