INT64928

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Context Info
Confidence 0.24
First Reported 1996
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.26
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LEPRE1) endoplasmic reticulum (LEPRE1) proteinaceous extracellular matrix (LEPRE1)
nucleus (LEPRE1) molecular_function (LEPRE1) cellular_component (LEPRE1)
Anatomy Link Frequency
blood 1
brainstem 1
LEPRE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 8 98.16 Very High Very High Very High
medulla 2 95.64 Very High Very High Very High
Autonomic response 2 93.68 High High
endometriosis 6 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 4 98.16 Very High Very High Very High
Targeted Disruption 5 96.96 Very High Very High Very High
Colon Cancer 98 96.04 Very High Very High Very High
Microsatellite Instability 41 95.96 Very High Very High Very High
Apoptosis 1 92.36 High High
Cancer 154 65.68 Quite High
Hereditary Nonpolyposis Colorectal Neoplasms 61 64.08 Quite High
Familial Adenomatous Polyposis 46 5.00 Very Low Very Low Very Low
Polyps 19 5.00 Very Low Very Low Very Low
Adenoma 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RNS-induced sensations of pain and increases in systemic arterial blood pressure were not correlated with the RNS-induced effects on the different segments of the PSEC.
Regulation (effects) of PSEC in blood associated with pain
1) Confidence 0.24 Published 1996 Journal Brain Res. Section Abstract Doc Link 8836560 Disease Relevance 0.10 Pain Relevance 0.26
The results suggest that RNS may affect particularly those elements of the PSEC evoked by higher threshold afferents and that the effects are mediated by mechanisms acting directly at the brainstem level and are not secondary to pain or autonomic responses.
Spec (may) Regulation (affect) of PSEC in brainstem associated with pain, medulla and autonomic response
2) Confidence 0.24 Published 1996 Journal Brain Res. Section Abstract Doc Link 8836560 Disease Relevance 0.19 Pain Relevance 0.28
We have reported (in this forum and published) that down-regulation of the growth-suppressor gene, cyclin-dependent kinase 2-associated protein 1 (CDK2-AP1) in microsatellite unstable (MSI) human colorectal cancer (CRC) cell lines is associated with increased proliferation and decreased apoptosis in those cell lines.
Regulation (regulation) of growth-suppressor gene associated with colon cancer and apoptosis
3) Confidence 0.00 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 0.98 Pain Relevance 0

General Comments

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