INT64952

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Context Info
Confidence 0.10
First Reported 1995
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.23
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DQA2) Golgi apparatus (HLA-DQA2) endoplasmic reticulum (HLA-DQA2)
plasma membrane (HLA-DQA2)
Anatomy Link Frequency
T-cell 3
immune system 1
HLA-DQA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 140 99.74 Very High Very High Very High
spinal inflammation 60 95.72 Very High Very High Very High
Etanercept 33 90.36 High High
Infliximab 10 89.76 High High
aspirin 1 87.32 High High
Inflammation 54 85.04 High High
Arthritis 25 70.80 Quite High
COX2 2 59.96 Quite High
cINOD 9 58.96 Quite High
Pain 23 55.32 Quite High
Disease Link Frequency Relevance Heat
Testicular Cancer 149 100.00 Very High Very High Very High
Malabsorption Syndromes 166 99.92 Very High Very High Very High
Rheumatoid Arthritis 143 99.74 Very High Very High Very High
Toxicity 7 97.56 Very High Very High Very High
Systemic Sclerosis 107 97.52 Very High Very High Very High
Low Back Pain 84 95.72 Very High Very High Very High
Disease 169 95.36 Very High Very High Very High
Wound Healing 2 95.12 Very High Very High Very High
Bacterial Infection 4 90.40 High High
Cancer 124 89.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The T-cell receptor theory is based on knowledge that this receptor recognizes only peptides that are in association with class I or class II MHC (Major Histocompatibility Complex) molecules.
class II MHC Binding (association) of in T-cell
1) Confidence 0.10 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721344 Disease Relevance 0.95 Pain Relevance 0.57
The modified gliadin peptides bind much better to HLA-DQ2 and elicit a stronger T cell response.
HLA-DQ2 Binding (bind) of in T cell
2) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1435993 Disease Relevance 0.41 Pain Relevance 0
Celiac disease is associated with HLA-DQ2/DQ8 in over 95% of the cases [102].
HLA-DQ2 Binding (associated) of associated with malabsorption syndromes
3) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1435993 Disease Relevance 0.71 Pain Relevance 0
Antiviral therapies targeted at CD4 can potentially have an undesired immunomodulatory effect, by either signaling through CD4 or blocking the interactions with MHC class II.
MHC class II Binding (interactions) of
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.16 Pain Relevance 0
Distinct CTA can encode for different antigenic peptides that are presented to the immune system in association with various human leukocyte antigens (HLA), HLA class I or HLA class II allospecificities, eliciting both cytotoxic T lymphocytes (CTL) and humoral immune responses.
HLA class II Binding (association) of in immune system
5) Confidence 0.03 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.82 Pain Relevance 0
The association between TGCT and HLA class II alleles either does not exist, or is much weaker than the earlier report suggested.
HLA class II Binding (association) of associated with testicular cancer
6) Confidence 0.02 Published 2008 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2735737 Disease Relevance 0.69 Pain Relevance 0
Furthermore, the pre-clinical serum anti-LPS and anti-type II collagen antibody levels in the responders were higher or tended to be higher than those in the non-responders, suggesting that there are 2 sub-types of RA based on an interaction between gastrointestinal pathogens and MHC class II haplotypes.


MHC class II Binding (interaction) of associated with rheumatoid arthritis
7) Confidence 0.02 Published 2011 Journal Nutr J Section Abstract Doc Link PMC3022554 Disease Relevance 0.44 Pain Relevance 0.15
First, B cells may act as antigen presentation cells and activate T cells through the interaction between the MHC class II molecule and the T cell receptor.
MHC class II molecule Binding (interaction) of in T cells
8) Confidence 0.02 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581826 Disease Relevance 0.53 Pain Relevance 0.29
It was recently observed that the prominent genetic risk factor HLA class II alleles only associate with susceptibility to RA in the presence of anti-CCP antibodies but not with RA in the absence of these antibodies (unpublished data, [5]).
HLA class II Binding (associate) of associated with rheumatoid arthritis
9) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257421 Disease Relevance 0.79 Pain Relevance 0.31
Furthermore, major histocompatibility complex (MHC) analyses have revealed strong associations of HLA class II alleles with serologically and clinically defined subsets of SSc [1,5].
HLA class II Binding (associations) of associated with systemic sclerosis
10) Confidence 0.01 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581823 Disease Relevance 1.59 Pain Relevance 0
HLA class II and HLA-B27 oligotyping in two Siberian native population groups.
HLA class II Binding (oligotyping) of
11) Confidence 0.01 Published 1995 Journal Tissue Antigens Section Title Doc Link 8838347 Disease Relevance 0.13 Pain Relevance 0.06

General Comments

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