INT64953

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Context Info
Confidence 0.58
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.15
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB1) Golgi apparatus (HLA-DRB1) endoplasmic reticulum (HLA-DRB1)
plasma membrane (HLA-DRB1)
Anatomy Link Frequency
Monocyte 1
lymphocytes 1
B cells 1
HLA-DRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 3 92.92 High High
pruritus 22 92.64 High High
corticosteroid 3 86.36 High High
Pain 2 85.68 High High
Bile 22 70.16 Quite High
headache 3 64.72 Quite High
antagonist 10 57.28 Quite High
beta blocker 22 42.24 Quite Low
nud 1 34.24 Quite Low
cytokine 20 29.08 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 46 100.00 Very High Very High Very High
Biliary Liver Cirrhosis 150 99.74 Very High Very High Very High
Autoimmune Hepatitis 13 96.64 Very High Very High Very High
Myocardial Infarction 98 94.60 High High
Lower Respiratory Tract Infection 1 94.08 High High
Low Back Pain 3 92.92 High High
Pruritus 22 92.64 High High
Syndrome 17 91.48 High High
Pain 2 85.68 High High
Hypopigmentation 5 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monocyte antigen HLA-DR was reduced in patients with "open" cholecystectomy.
Negative_regulation (reduced) of HLA-DR in Monocyte
1) Confidence 0.58 Published 1999 Journal World J Surg Section Abstract Doc Link 9841758 Disease Relevance 0.18 Pain Relevance 0.09
The determination of the HLA-DRB1 alleles was performed by using the Allele SEQR HLA Sequencing kit with Heterozygous ambiguity resolving primers (AlleleSEQR HLA Sequencing kit+ HARPs; Atria Genetics, Inc.
Negative_regulation (determination) of HLA-DRB1
2) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743806 Disease Relevance 0.93 Pain Relevance 0.06
Here, we describe newly identified block associations within the MHC, specifically determining the distribution of HLA-E alleles in relation to HLA-A, B, Cw, complotype and DRB1 blocks, defining a set of CEHs extending over 2.6 Mb (1.5% of chromosome 6).
Negative_regulation (blocks) of DRB1
3) Confidence 0.41 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0.15 Pain Relevance 0
HLA-class II typing in 70 Siberian Eskimos and 71 Siberian coastal Chukchi revealed HLA-DRB1*0401, DRB1*0802, *0901 and *1402 to account for nearly all the DRB1 alleles found in this population, similar to what has been described in Eskimos in Alaska, but different from Chinese or native Americans in the U.S.
Negative_regulation (revealed) of DRB1
4) Confidence 0.18 Published 1995 Journal Tissue Antigens Section Abstract Doc Link 8838347 Disease Relevance 0.18 Pain Relevance 0.09
HLA-class II typing in 70 Siberian Eskimos and 71 Siberian coastal Chukchi revealed HLA-DRB1*0401, DRB1*0802, *0901 and *1402 to account for nearly all the DRB1 alleles found in this population, similar to what has been described in Eskimos in Alaska, but different from Chinese or native Americans in the U.S.
Negative_regulation (revealed) of HLA-DRB1
5) Confidence 0.15 Published 1995 Journal Tissue Antigens Section Abstract Doc Link 8838347 Disease Relevance 0.18 Pain Relevance 0.09
However, a small study of HLA typing in AMA positive and negative PBC indicated a lack of DR8 in those AMA negative cases [139].


Negative_regulation (lack) of DR8 associated with biliary liver cirrhosis
6) Confidence 0.05 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 2.02 Pain Relevance 0.20
Significant negative correlations existed between serum levels of sTNFR-1 and the relative number of lymphocytes, CD3+ T cells, T helper cells, B cells, and HLA-DR expressing lymphocytes (Table 3).
Negative_regulation (number) of HLA-DR in B cells
7) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713422 Disease Relevance 0.63 Pain Relevance 0
Similarly, there was a negative correlation between sTNFR-2 and the relative number of lymphocytes and HLA-DR expressing lymphocytes (Table 3).
Negative_regulation (number) of HLA-DR in lymphocytes
8) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713422 Disease Relevance 0.57 Pain Relevance 0.03
The acxB gene in H. pylori SS1, which is a mouse-adapted strain, was disrupted with a chloramphenicol resistance (cat) cassette.
Negative_regulation (disrupted) of SS1 associated with sprains and strains
9) Confidence 0.02 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2244623 Disease Relevance 0.31 Pain Relevance 0

General Comments

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