INT64956

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Context Info
Confidence 0.19
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.40
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) extracellular space (IL6) aging (IL6)
extracellular region (IL6) nucleus (IRF6) DNA binding (IRF6)
IRF6 (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 95 100.00 Very High Very High Very High
Inflammatory response 24 99.92 Very High Very High Very High
chemokine 13 99.76 Very High Very High Very High
Inflammation 127 91.96 High High
sodium channel 5 62.44 Quite High
tetrodotoxin 1 55.44 Quite High
metalloproteinase 10 50.00 Quite Low
rheumatoid arthritis 3 50.00 Quite Low
agonist 56 5.00 Very Low Very Low Very Low
fibrosis 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 157 99.52 Very High Very High Very High
Edema 1 93.28 High High
Cancer 22 85.88 High High
Pituitary Cancer 4 84.16 Quite High
Adenoma 1 74.64 Quite High
Sepsis 5 72.24 Quite High
Hepatotoxicity 3 71.28 Quite High
Cardiovascular Disease 20 68.40 Quite High
Injury 38 55.20 Quite High
Disease 27 51.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The spontaneous and LPS induced synthesis of IL-6 was significantly inhibited by tenidap at all concentrations tested, whereas neither concentration of naproxen demonstrated a significant effect.
LPS Positive_regulation (induced) of Gene_expression (synthesis) of IL-6
1) Confidence 0.19 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8838503 Disease Relevance 0 Pain Relevance 0
LPS-induced IL-6 protein synthesis and IL-6 bioactivity were also reduced to baseline levels by the PTK inhibitors herbimycin A and genistein.
LPS Positive_regulation (induced) of Gene_expression (synthesis) of IL-6
2) Confidence 0.03 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.57 Pain Relevance 0.04
LPS and fibrinogen stimulate the expression of similar cytokines (for example, IL-6) and chemokines (for example, MCP-1), and activate the transcriptional factors NF-?
LPS Positive_regulation (stimulate) of Gene_expression (expression) of IL-6 associated with chemokine and cytokine
3) Confidence 0.01 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.84 Pain Relevance 0.35
They reported that LPS-induced IL-6 production was due at least in part by calcium mobilization solely from intracellular sources and partly by entry of extracellular calcium through TRPV2.
LPS Positive_regulation (induced) of Gene_expression (production) of IL-6
4) Confidence 0.01 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0 Pain Relevance 0.24

General Comments

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